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Fig. 6 | BMC Immunology

Fig. 6

From: Influenza virus-like particle vaccine containing both apical membrane antigen 1 and microneme-associated antigen proteins of Plasmodium berghei confers protection in mice

Fig. 6

T cell response and pro-inflammatory cytokines in the spleen. Mice spleen were collected at 6 dpi, and the levels of CD4+, CD8+ T cells, and pro-inflammatory cytokines IFN-γ and TNF-α were determined. As shown in A and B, increased splenic CD4+ T cell populations were observed (A, *P < 0.05), whereas no changes were observed for CD8+ T cells (B). To determine the levels of pro-inflammatory cytokines IFN-γ and TNF-α, OptEIA IFN-γ and TNF-α ELISA kits (BD) were used. The levels of IFN-γ and TNF-α were significantly decreased in the VLP-immunized group compare to naïve challenge control (C, D, * P < 0.05)

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BMC Immunology

ISSN: 1471-2172

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