Fig. 2

HLA-DRB1 alleles with incidence of over 2% in controls or patients with OBI 1. Alleles with known crystal structure are in bold. 2. Identity in residues is indicated by _, while unknown residues are shown as *. 3. Symbols below the sequence of the last allele: For antigen binding (highlighted in yellow): residues participating in the formation of a particular pocket indicated by the number of the pocket (1, 4, 6, 7, 9) at the bottom of the column; in case a residue participates in more than one pockets this is indicated by numbers on two lines. For interchain interactions:!, residues forming hydrogen bonds with antigenic peptide backbone, or interchain salt bridges via oppositely charged side chains (highlighted in red). Disulfide bridges in orange. ~ : intra-chain salt bridges marked with respective charge signs are in blue. G^11β, Y^13β, K^14β, Q^25β, L^30β, Q^74β have not found in any of the other alleles.