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Table 4 Susceptible of HLA-DRB1 amino acid residues associations with OBI

From: High resolution HLA-DRB1 analysis and shared molecular amino acid signature of DRβ1 molecules in Occult hepatitis B infection

Amino acid position

Amino acid variants

OBI (AA-F%) 2n = 214

Control (AA-F%) 2n = 560

p value

Pc

OR

95% CI

4

Glutamine (Q)

76 (35.51)

131 (23.39)

0.0010

0.031

1.804

1.282–2.538

 

All others

138 (64.49)

429 (76.61)

    

11

Glycine (G)

41 (19.16)

59 (10.54)

0.0025

0.0775

2.012

1.303–3.108

 

All others

173 (80.84)

501 (89.46)

    

13

Tyrosine (Y)

41 (19.16)

59 (10.54)

0.0025

0.0775

2.012

1.303–3.108

 

All others

173 (80.84)

501 (89.46)

    

14

Lysine (K)

41 (19.16)

59 (10.54)

0.0025

0.0775

2.012

1.303–3.108

 

All others

173 (80.84)

501 (89.46)

    

25

Glutamine (Q)

41 (19.16)

59 (10.54)

0.0025

0.0775

2.012

1.303–3.108

 

All others

173 (80.84)

501 (89.46)

    

28

Glutamic acid (E)

81 (37.85)

163 (29.11)

0.0244

0.7564

1.483

1.065–2.065

 

All others

133 (62.15)

397 (70.89)

    

30

Leucine (L)

41 (19.16)

59 (10.54)

0.0025

0.0775

2.012

1.303–3.108

 

All others

173 (80.84)

501 (89.46)

    

37

Phenylalanine (F)

54 (25.23)

92 (16.43)

0.0074

0.2294

1.717

1.173–2.513

 

All others

160 (74.77)

468 (83.57)

    

57

Valine (V)

111 (51.87)

205 (36.61)

0.0002

0.0062

1.866

1.357–2.566

 

All others

103 (48.13)

355 (63.39)

    

60

Serine (S)

111 (51.87)

205 (36.61)

0.0002

0.0062

1.866

1.357–2.566

 

All others

103 (48.13)

355 (63.39)

    

73

Glycine (G)

51 (23.83)

84 (15.00)

0.0058

0.1798

1.762

1.192–2.604

 

All others

164 (76.64)

476 (85.00)

    

74

Glutamine (Q)

41 (19.16)

59 (10.54)

0.0025

0.0775

2.012

1.303–3.108

 

All others

173 (80.84)

501 (89.46)

    

78

Valine (V)

76 (35.51)

131 (23.39)

0.0010

0.031

1.804

1.282–2.538

 

All others

138 (64.49)

429 (76.61)

    
  1. OBI, occult hepatitis B infection; AA-F, amino acid frequency; OR, odds ratio; 95%CI, 95% confidence interval; Pc, corrected P.
  2. In bold: significant value of Pc < 0.05