Table 5 HLA-DRB1 amino acid variants that showed strong association with OBI carriers
Amino acid position | Amino acid variants | OBI (AA-F%) 2n = 214 | Control (AA-F%) 2n = 560 | p value | OR | 95% CI |
|---|---|---|---|---|---|---|
4 | Glutamine (Q) | 76 (35.51) | 131 (23.39) | 0.0010 | 1.804 | 1.282–2.538 |
Arginine (R) | 137 (64.02) | 429 (76.61) | 0.0006 | 0.5433 | 0.3863–0.7641 | |
Undetermined | 1 (0.47) | 0 (0.00) | NS | |||
57 | Alanine (A) | 3 (1.40) | 21 (3.75) | NS | ||
Aspartic acid (D) | 85 (39.72) | 271 (48.39) | 0.0359 | 0.7027 | 0.5102–0.9678 | |
Serine (S) | 15 (7.01) | 63 (11.25) | NS | |||
Valine (V) | 111 (51.87) | 205 (36.61) | 0.0002 | 1.866 | 1.357–2.566 | |
60 | Histidine (H) | 3 (1.40) | 21 (3.75) | NS | ||
Serine (S) | 111 (51.87) | 205 (36.61) | 0.0002 | 1.866 | 1.357–2.566 | |
Tyrosine (Y) | 100 (46.73) | 334 (59.64) | 0.0016 | 0.5935 | 0.4322–0.8152 | |
78 | Valine (V) | 76 (35.51) | 131 (23.39) | 0.0010 | 1.804 | 1.282–2.538 |
Tyrosine (Y) | 138 (64.49) | 429 (76.61) | 0.0010 | 0.5545 | 0.3940–0.7803 |