Immune correlates of cardiovascular co-morbidity in HIV infected participants from South India

BMC Immunology

Table 2 Measures of cardiac functions, and arterial stiffness in HIV + treatmentnaïve, on ART, and HIV uninfected participants

Clinical parameters	Group 1; (n = 102)	Group 2; (n = 172)	Group 3; (n = 64)	p-value; Gp 1 vs 2	p- value; Gp 1 vs 3	p- value; Gp 2 vs 3
Estimated cardiac ejection time (millisec)	288 (264, 305)	305 (280, 325)	304 (288, 324.5)	< 0.001*	< 0.001*	0.623
Estimated stroke volume (ml/beat)	61 (50, 72)	71 (58, 80)	70 (60.5, 80)	< 0.001*	< 0.001*	0.661
Estimated stroke volume index (ml/beat/m²)	38 (32, 44)	42 (36, 49)	43 (38.5, 48)	< 0.001*	< 0.001*	0.434
Estimated cardiac output (L/min)	4.8 (4.3, 5.3)	5 (4.5, 5.6)	5.1 (4.7, 5.65)	0.008*	0.005*	0.383
Estimated cardiac index (L/min/m²)	3 (2.7, 3.3)	3.05 (2.8, 3.3)	3.1 (2.95, 3.4)	0.077	0.004*	0.071
Large artery elasticity index
(ml/mmHg × 10)	12.8 (9.7, 16.2)	14.5 (11.5, 18)	13.1 (10.25, 16)	0.001*	0.356	0.06
Small artery elasticity index
(ml/mmHg × 100)	4.4 (2.8, 5.9)	4.75 (3.4, 6.5)	5.4 (3.55, 6.75)	0.019*	0.01*	0.526
Systemic vascular resistance
(dyne.sec.cm⁻⁵)	1431 (1256, 1663)	1325.5 (1162, 1528)	1315 (1178.5, 1542)	0.003*	0.006*	0.735
Total vascular impedance (dyne.sec.cm⁻⁵)	127 (102, 155)	119.5 (99, 140)	128 (113, 155)	0.046*	0.64	0.024*
Right IMT (in cm)	0.05 (0.05, 0.06)	0.05 (0.04, 0.06)	0.05 (0.04, 0.06)	0.172	0.036*	0.269
Left IMT (in cm)	0.05 (0.04, 0.06)	0.05 (0.04, 0.06)	0.05 (0.04, 0.06)	0.212	0.667	0.142

Group 1; Naïve patients, Group 2; Patients on ART, Group 3; HIV-uninfected controls. All continuous variables are presented as median and interquartile ranges in parenthesis. Mann–Whitney U-test was used to calculate p-value between the study groups
*Indicates statistically significant differences
ART = anti-retroviral therapy, IMT = intima-media thickness, ml = milliliter, L = Liter

ISSN: 1471-2172