Immune correlates of cardiovascular co-morbidity in HIV infected participants from South India

Kausalya, Bagavathi; Saravanan, Shanmugam; Pallikkuth, Suresh; Pahwa, Rajendra; Saini, Shelly Rani; Iqbal, Syed; Solomon, Sunil; Murugavel, Kailapuri G.; Poongulali, Selvamuthu; Kumarasamy, Nagalingeswaran; Pahwa, Savita

doi:10.1186/s12865-022-00498-0

BMC Immunology

Table 5 Correlation coefficient of cardiac functional and arterial stiffness markers of inflammation and microbial translocation in HIV + treatment naïve participants

From: Immune correlates of cardiovascular co-morbidity in HIV infected participants from South India

Sub-clinical CVD markers	Statistics	TNFR1 (pg/mL)	TNFR2 (pg/mL)	IFN-α2 (pg/mL)	IFN-γ (pg/mL)	IL10 (pg/mL)	IL2 (pg/mL)	IL6 (pg/mL)	TNF-α (pg/mL)	LPS (pg/mL)	sCD14 (ng/mL)
Estimated cardiac ejection time (msec)	Spearman (R)	−0.223*	−0.154	0.165	0.109	0.136	0.183	−0.071	−0.101	−0.186	−0.261*
	p value	0.025	0.125	0.099	0.277	0.175	0.068	0.48	0.315	0.063	0.008
Estimated stroke volume (ml/beat)	Spearman (R)	−0.370*	−0.324*	0.082	−0.012	0.036	0.096	−0.257*	−0.222*	−0.259*	−0.362*
	p value	< 0.001	0.001	0.414	0.908	0.724	0.341	0.009	0.026	0.009	< 0.001
Estimated stroke volume index (ml/beat/m²)	Spearman (R)	−0.350*	−0.264*	0.142	0.049	0.096	0.155	−0.221*	−0.195	−0.323*	−0.338*
	p value	< 0.001	0.008	0.156	0.627	0.339	0.123	0.027	0.05	0.001	0.001
Estimated cardiac output (L/min)	Spearman (R)	−0.377*	−0.290*	0.057	0.003	0.043	0.08	−0.251*	−0.203*	−0.219*	−0.263*
	p value	< 0.001	0.003	0.57	0.978	0.672	0.429	0.012	0.042	0.028	0.008
Estimated cardiac index (L/min/m²)	Spearman (R)	−0.329*	−0.171	0.134	0.095	0.134	0.158	−0.183	−0.164	−0.292*	−0.209*
	p value	0.001	0.087	0.18	0.347	0.181	0.115	0.067	0.102	0.003	0.036
Large artery elasticity index (ml/mmHg × 10)	Spearman (R)	−0.310*	−0.302*	0.05	−0.146	0.015	−0.036	−0.316*	−0.131	−0.151	−0.273*
	p value	0.002	0.002	0.621	0.146	0.884	0.72	0.001	0.193	0.133	0.006
Small artery elasticity index (ml/mmHg × 100)	Spearman (R)	−0.098	−0.126	0.213*	0.124	0.069	0.234*	−0.069	0.009	−0.239*	−0.075
	p value	0.332	0.209	0.033	0.217	0.494	0.019	0.495	0.93	0.016	0.453
Systemic vascular resistance (dyne.sec.cm⁻⁵)	Spearman (R)	0.355*	0.292*	−0.077	0.005	−0.066	−0.06	0.334*	0.15	0.313*	0.098
	p value	< 0.001	0.003	0.442	0.964	0.515	0.553	0.001	0.134	0.001	0.331
Total vascular impedance	Spearman (R)	0.348*	0.323*	−0.042	0.107	−0.025	0.047	0.363*	0.146	0.113	0.165
	p value	< 0.001	0.001	0.675	0.285	0.802	0.643	< 0.001	0.144	0.262	0.099

*Indicates statistically significant correlations. Spearman correlation was used to identify correlations

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