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Fig. 6 | BMC Immunology

Fig. 6

From: NLRP3 inflammasome up-regulates major histocompatibility complex class I expression and promotes inflammatory infiltration in polymyositis

Fig. 6

MCC950 alleviates the intensity of inflammation and MHC-I expression in PM model rats. A, B The muscle section samples of PM modal rats showed a substantial reduction in muscle histological inflammation scores after treated by MCC950. C–E Serum CRP, CK, and LDH levels were significantly reduced after MCC950 treatment in PM modal rats. F–I The expression of NLRP3, MHC-I, and IL-1β were effectively reduced in the muscle tissue of PM model rats by MCC950 treatment. **p < 0.001, compared with control group; ¶p < 0.01, ¶¶p < 0.001, compared with before treatment. Scale bars, 50 μm (original magnification, ×400)

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