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Clinical immunology: transplants, autoimmunity and vaccines

Section edited by Lucienne Chatenoud

This section aims to publish studies on all immunological aspects of cell, organ and tissue transplantation, clinical aspects of autoimmunity and all aspects of vaccine research: development and evaluation of vaccines, immune responses to vaccines, vaccine vectors, adjuvants and immunomodulators, assays of vaccine efficacy, and clinical trials.

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  1. HLA class II tetramers can be used for ex vivo enumeration and phenotypic characterisation of antigen-specific CD4+ T cells. They are increasingly applied in settings like allergy, vaccination and autoimmune d...

    Authors: Christina Gerstner, Sara Turcinov, Aase H. Hensvold, Karine Chemin, Hannes Uchtenhagen, Tamara H. Ramwadhdoebe, Anatoly Dubnovitsky, Genadiy Kozhukh, Lars Rönnblom, William W. Kwok, Adnane Achour, Anca I. Catrina, Lisa G. M. van Baarsen and Vivianne Malmström

    Citation: BMC Immunology 2020 21:27

    Content type: Research article

    Published on:

  2. It is widely hoped that personal cancer vaccines will extend the number of patients benefiting from checkpoint and other immunotherapies. However, it is clear creating such vaccines will be challenging. It req...

    Authors: Milene Peterson, Sierra Nicole Murphy, John Lainson, Jian Zhang, Luhui Shen, Chris W. Diehnelt and Stephen Albert Johnston

    Citation: BMC Immunology 2020 21:25

    Content type: Research article

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  3. CD8+CD28 T suppressor (Ts) cells play critical role in transplant tolerance. Our previous study has generated CD8+CD28 Ts cells in vitro which exert robust allospecific suppressive capacity in vitro.

    Authors: Guihuan Liu, Yuming Yu, Fu Feng, Ping Zhu, Hua Zhang, Danni Zhang, Xiaoqiang Feng, Zedan Zhang and Yanjun Liu

    Citation: BMC Immunology 2020 21:23

    Content type: Research article

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  4. Although immunoglobulin A nephropathy (IgAN) is one of the foremost primary glomerular disease, treatment of IgAN is still in infancy. Non-invasive biomarkers are urgently needed for IgAN diagnosis. We investi...

    Authors: Na Guo, Qin Zhou, Xiang Huang, Jianwen Yu, Qianqian Han, Baoting Nong, Yuanyan Xiong, Peifen Liang, Jiajia Li, Min Feng, Jun Lv and Qiongqiong Yang

    Citation: BMC Immunology 2020 21:16

    Content type: Research article

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  5. The use of anti-B cell based therapies in immune-mediated diseases targeting general B cell markers or molecules important for B cell function has increased the clinical needs of monitoring B cell subpopulations.

    Authors: Susanne Axelsson, Anders Magnuson, Anna Lange, Aseel Alshamari, Elisabeth Hultgren Hörnquist and Olof Hultgren

    Citation: BMC Immunology 2020 21:14

    Content type: Research article

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  6. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) and immunosuppressive therapy (IST) are two major competing treatment strategies for acquired aplastic anemia (AA). Whether allo-HSCT is superior ...

    Authors: Yangmin Zhu, Qingyan Gao, Jing Hu, Xu Liu, Dongrui Guan and Fengkui Zhang

    Citation: BMC Immunology 2020 21:10

    Content type: Research article

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  7. In this study, seven adjuvants were compared for use with Plasmodium falciparum DiCo-Apical Membrane Antigen 1 (Pf-DiCo-AMA1), with the aim to identify an ideal adjuvant which yields high antibody titres and pote...

    Authors: Sumera Younis, Bart W. Faber, Clemens H.M. Kocken and Edmond J. Remarque

    Citation: BMC Immunology 2019 20:25

    Content type: Research article

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  8. Active immunotherapy targeting amyloid-β (Aβ) is a promising treatment for Alzheimer’s disease (AD). Numerous preclinical studies and clinical trials demonstrated that a safe and effective AD vaccine should in...

    Authors: Ping Yang, Yongqing Guo, Yao Sun, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu and Wei Kong

    Citation: BMC Immunology 2019 20:9

    Content type: Research article

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  9. Little is known about the presence of specific autoantibodies in ankylosing spondylitis (AS), an immune-mediated inflammatory disease. The object of this study was to explore potential autoantibody profiles in...

    Authors: Qiongyi Hu, Yue Sun, Yuan Li, Hui Shi, Jialin Teng, Honglei Liu, Xiaobing Cheng, Junna Ye, Yutong Su, Yufeng Yin, Mengru Liu, Jiucun Wang and Chengde Yang

    Citation: BMC Immunology 2018 19:38

    Content type: Research article

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  10. Transcriptional profiling with ultra-low input methods can yield valuable insights into disease, particularly when applied to the study of immune cells using RNA-sequencing. The advent of these methods has all...

    Authors: Brittany A. Goods, Jacqueline M. Vahey, Arthur F. Steinschneider, Michael H. Askenase, Lauren Sansing and J. Christopher Love

    Citation: BMC Immunology 2018 19:30

    Content type: Research article

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    The Correction to this article has been published in BMC Immunology 2018 19:42

  11. While vaccination remains the most effective method to control hepatitis B virus (HBV) infection, 5–10% of recipients exhibit non-responsiveness to the HB vaccine. Immunological analysis of strong, weak or abs...

    Authors: Xiaojia Xu, Yulian Li, Yaping Liang, Mingjuan Yin, Zuwei Yu, Yan Zhang, Lingfeng Huang and Jindong Ni

    Citation: BMC Immunology 2018 19:25

    Content type: Research article

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  12. Although a safe and effective yellow fever vaccine was developed more than 80 years ago, several issues regarding its use remain unclear. For example, what is the minimum dose that can provide immunity against...

    Authors: Carla R. B. Bonin, Guilherme C. Fernandes, Rodrigo W. dos Santos and Marcelo Lobosco

    Citation: BMC Immunology 2018 19:15

    Content type: Research article

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  13. Hu-rhEGF-rP64k/Mont is a biotechnology product for the treatment of advanced non-small cell lung cancer (NSCLC). The vaccine induces a neutralizing antibody-mediated immune response, against the normal circula...

    Authors: Puyuan Xing, Hongyu Wang, Sheng Yang, Xiaohong Han, Yan Sun and Yuankai Shi

    Citation: BMC Immunology 2018 19:14

    Content type: Research article

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  14. Type 1 diabetes (T1D) is thought to be an autoimmune disease driven by anti-islet antigen responses and mediated by T-cells. Recent published data suggests that T-cell reactivity to modified peptides, effectiv...

    Authors: John Sidney, Jose Luis Vela, Dave Friedrich, Ravi Kolla, Matthias von Herrath, Johnna D. Wesley and Alessandro Sette

    Citation: BMC Immunology 2018 19:12

    Content type: Research article

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  15. The Haemophilus influenzae type b (Hib) conjugate vaccine has been widely used in children to prevent invasive Hib disease because of its strong immunogenicity and antibody response induction relative to the caps...

    Authors: Jing Tang, Ying Zhang, Xiaolong Zhang, Yun Liao, Yongrong Wang, Shengjie Ouyang, Yanchun Che, Miao Xu, Jing Pu, Qi Shen, Zhanlong He, Qiang Ye and Qihan Li

    Citation: BMC Immunology 2018 19:4

    Content type: Research Article

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  16. Non-adherence has been associated with reduced graft survival. The aim of this study was to investigate the immunological mechanisms underlying chronic renal allograft rejection using a model of non-adherence ...

    Authors: Louisa Kühne, Bettina Jung, Helen Poth, Antonia Schuster, Simone Wurm, Petra Ruemmele, Bernhard Banas and Tobias Bergler

    Citation: BMC Immunology 2017 18:52

    Content type: Research article

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  17. It is well known that ABO blood group system incompatible kidney transplantation (ABOi-KT) is an effective strategy for end-stage renal disease. The main barrier for ABOi-KT is how to keep host B cell activati...

    Authors: Jingsong Cao, Luogen Liu, Yunsheng Zhang, Jianhua Xiao and Yi Wang

    Citation: BMC Immunology 2017 18:49

    Content type: Research article

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  18. The most important factors that affect the incidence of vaccine-related complications are the constituent biological components of the vaccine, injection site reactions, age and sex. The aim of this study is t...

    Authors: Manoochehr Karami, Pegah Ameri, Jalal Bathaei, Zeinab Berangi, Tahereh Pashaei, Ali Zahiri, Seyed Mohsen Zahraei, Hussein Erfani and Koen Ponnet

    Citation: BMC Immunology 2017 18:42

    Content type: Research article

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    The Correction to this article has been published in BMC Immunology 2017 18:45

  19. Cancer therapeutic vaccine induced cytotoxic T cell (CTL) responses are pivotal for the killing of tumour cells. Blocking interleukin 10 (IL-10) signalling at the time of immunization increases vaccine induced...

    Authors: Guoying Ni, Zaowen Liao, Shu Chen, Tianfang Wang, Jianwei Yuan, Xuan Pan, Kate Mounsey, Shelley Cavezza, Xiaosong Liu and Ming Q. Wei

    Citation: BMC Immunology 2017 18:40

    Content type: Research article

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  20. CIGB-247, a VSSP-adjuvanted VEGF-based vaccine, was evaluated in a phase I clinical trial in patients with advanced solid tumors (CENTAURO). Vaccination with the maximum dose of antigen showed an excellent saf...

    Authors: Javier Sánchez Ramírez, Yanelys Morera Díaz, Mónica Bequet-Romero, Francisco Hernández-Bernal, Katty-Hind Selman-Housein Bernal, Ana de la Torre Santos, Eduardo Rafael Santiesteban Álvarez, Yenima Martín Bauta, Cimara H. Bermúdez Badell, Josué de la Torre Pupo, Jorge V. Gavilondo and Marta Ayala Avila

    Citation: BMC Immunology 2017 18:39

    Content type: Research article

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  21. Previous studies have shown that γδ TFH cells are capable of modulating antibody production in immunized and infected mouse model. In recent studies, human γδ TFH cells are shown to contribute to the activatio...

    Authors: Wenjun Mou, Wei Han, Xiaoli Ma, Xiaolin Wang, Hong Qin, Wen Zhao, Xiaoya Ren, Xi Chen, Wei Yang, Haiyan Cheng, Xisi Wang, Hui Zhang, Xin Ni, Huanmin Wang and Jingang Gui

    Citation: BMC Immunology 2017 18:36

    Content type: Research article

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  22. The monoclonal gammopathies are a group of plasma-cell proliferative disorders characterized by the secretion of monoclonal immunoglobulin (M protein or paraprotein). Some rare cases have revealed the specific...

    Authors: Xin-yao Wu, Yu-feng Yin, Jia-lin Teng, Li-wei Zhang and Cheng-de Yang

    Citation: BMC Immunology 2017 18:32

    Content type: Research article

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  23. Recent fundamental and clinical studies have confirmed the effectiveness of utilizing the potential of the immune system to remove tumor cells disseminated in a patient’s body. Cytotoxic T lymphocytes (CTLs) a...

    Authors: Maria Kuznetsova, Julia Lopatnikova, Julia Khantakova, Rinat Maksyutov, Amir Maksyutov and Sergey Sennikov

    Citation: BMC Immunology 2017 18:31

    Content type: Methodology article

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  24. Humanized mice (hu mice) are based on the transplantation of hematopoietic stem and progenitor cells into immunodeficient mice and have become important pre-clinical models for biomedical research. However, da...

    Authors: Annette Audigé, Mary-Aude Rochat, Duo Li, Sandra Ivic, Audrey Fahrny, Christina K. S. Muller, Gustavo Gers-Huber, Renier Myburgh, Simon Bredl, Erika Schlaepfer, Alexandra U. Scherrer, Stefan P. Kuster and Roberto F. Speck

    Citation: BMC Immunology 2017 18:28

    Content type: Research article

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  25. T-helper cell type 1 (Th1) polarization in chronic immune thrombocytopenia (cITP) has been reported at the protein and mRNA levels. We evaluated the impact of Th1/Th2 cytokine and cytokine receptor functional ...

    Authors: Noriyuki Takahashi, Takayuki Saitoh, Nanami Gotoh, Yasuhiro Nitta, Lobna Alkebsi, Tetsuhiro Kasamatsu, Yusuke Minato, Akihiko Yokohama, Norifumi Tsukamoto, Hiroshi Handa and Hirokazu Murakami

    Citation: BMC Immunology 2017 18:26

    Content type: Research article

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  26. To assess the impact of disease activity on health-related quality of life (HRQoL) in systemic lupus erythematosus (SLE).

    Authors: Benjamin Chaigne, Carlo Chizzolini, Thomas Perneger, Marten Trendelenburg, Uyen Huynh-Do, Eric Dayer, Thomas Stoll, Johannes von Kempis and Camillo Ribi

    Citation: BMC Immunology 2017 18:17

    Content type: Research article

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  27. Oxidative damage present in obese/overweight mothers may lead to further oxidative stress conditions or inflammation in maternal and cord blood samples. Thirty-four pregnant women/newborn pairs were included i...

    Authors: María Hernández-Trejo, Araceli Montoya-Estrada, Yessica Torres-Ramos, Aurora Espejel-Núñez, Alberto Guzmán-Grenfell, Rosa Morales-Hernández, Maricruz Tolentino-Dolores and Estibalitz Laresgoiti-Servitje

    Citation: BMC Immunology 2017 18:3

    Content type: Research Article

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  28. Cytomegalovirus seropositivity is an independent risk factor for atherosclerosis in patients with ESRD. Donor CMV seropositivity is associated with higher graft loss. Dendritic cells, macrophages and Th17 lymp...

    Authors: Mahmoud Sadeghi, Imad Lahdou, Gerhard Opelz, Arianeb Mehrabi, Martin Zeier, Paul Schnitzler and Volker Daniel

    Citation: BMC Immunology 2016 17:35

    Content type: Research article

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  29. Despite recent advances in early detection and improvements in chemotherapy for colon cancer, the patients still face poor prognosis of postoperative recurrence and metastasis, the median survival for patients...

    Authors: Huanyu Ju, Wenjing Xing, Jinfeng Yang, Yang Zheng, Xiuzhi Jia, Benning Zhang and Huan Ren

    Citation: BMC Immunology 2016 17:31

    Content type: Research article

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  30. Interleukin-15 is an immunostimulatory cytokine overexpressed in several autoimmune and inflammatory diseases such as Rheumatoid Arthritis, psoriasis and ulcerative colitis; thus, inhibition of IL-15-induced s...

    Authors: Yunier Rodríguez-Álvarez, Yanelys Morera-Díaz, Haydee Gerónimo-Pérez, Jorge Castro-Velazco, Rafael Martínez-Castillo, Pedro Puente-Pérez, Vladimir Besada-Pérez, Eugenio Hardy-Rando, Araceli Chico-Capote, Klaudia Martínez-Cordovez and Alicia Santos-Savio

    Citation: BMC Immunology 2016 17:30

    Content type: Research article

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  31. Chronic eosinophilic pneumonia (CEP) or eosinophilic gastroenteritis (EG), or both, with asthma precede the onset of eosinophilic granulomatosis with polyangiitis (EGPA) in half of all EGPA patients. It is not...

    Authors: Naomi Tsurikisawa, Chiyako Oshikata, Takahiro Tsuburai, Satoshi Sugano, Yoko Nakamura, Takuya Shimoda, Shunpei Tamama, Ken Adachi, Ayako Horita, Ikuo Saito and Hiroshi Saito

    Citation: BMC Immunology 2015 16:75

    Content type: Research article

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  32. Mesenchymal stromal cells (MSCs) are multipotent progenitor cells known to modulate the immune system and to promote hematopoiesis. These dual effects make MSCs attractive for use as cellular therapy in hemato...

    Authors: Elizabeth O. Stenger, Lakshmanan Krishnamurti and Jacques Galipeau

    Citation: BMC Immunology 2015 16:74

    Content type: Review

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  33. Despite effective antiretroviral therapy (ART), HIV-infected patients exhibit systemic inflammation, early onset of age-related diseases, and features of immunosenescence. The role of inflammation in the devel...

    Authors: Juliette Tavenier, Anne Langkilde, Thomas Huneck Haupt, Jens Henrik Henriksen, Frank Krieger Jensen, Janne Petersen and Ove Andersen

    Citation: BMC Immunology 2015 16:72

    Content type: Research article

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  34. To initiate mucosal immune responses, antigens in the intestinal lumen must be transported into gut-associated lymphoid tissue through M cells. Recently, it has been increasingly recognized that receptor activ...

    Authors: Jeong-In Kim, Tae-Eun Park, Sushila Maharjan, Hui-Shan Li, Ho-Bin Lee, In-Seon Kim, Dachuan Piao, Jun-Yeong Lee, Chong-Su Cho, Jin-Duck Bok, Zhong-Shan Hong, Sang-Kee Kang and Yun-Jaie Choi

    Citation: BMC Immunology 2015 16:71

    Content type: Research article

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  35. Requisites for an efficacious tuberculosis (TB) vaccine are a minimal genomic diversity among infectious Mycobacterium tuberculosis strains for the selected antigen, and the capability to induce robust T-cell res...

    Authors: Marie-Cécile Mortier, Erik Jongert, Pascal Mettens and Jean-Louis Ruelle

    Citation: BMC Immunology 2015 16:63

    Content type: Research article

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  36. The chronic course of pulmonary sarcoidosis can lead to lung dysfunction due to fibrosis, in which the signalling pathways TGF-β/Smad and VEGF-A may play a key role.

    Authors: Wojciech J. Piotrowski, Justyna Kiszałkiewicz, Paweł Górski, Adam Antczak, Witold Górski, Dorota Pastuszak-Lewandoska, Monika Migdalska-Sęk, Daria Domańska-Senderowska, Ewa Nawrot, Karolina H. Czarnecka, Zofia Kurmanowska and Ewa Brzeziańska-Lasota

    Citation: BMC Immunology 2015 16:58

    Content type: Research article

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  37. A significant barrier to organ transplantation is the cellular rejection that occurs and mediated by antibodies, T cells, and innate immune cells. This study was aimed to determine the number of CD4+CD25+Foxp3+ T...

    Authors: Liang Ma, Huimao Zhang, Kebang Hu, Guoyue Lv, Yaowen Fu, Desalegn Admassu Ayana, Pingwei Zhao and Yanfang Jiang

    Citation: BMC Immunology 2015 16:56

    Content type: Research article

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  38. Macrophage migration inhibitory factor (MIF) is a cytokine that shares many activities with other pro-inflammatory cytokines in primary glomerulonephritis (GN). This study assesses the influence of immunosuppr...

    Authors: Rafał Zwiech

    Citation: BMC Immunology 2015 16:47

    Content type: Research article

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  39. Our informal observations suggested that some patients with acute sensorineural hearing loss (ASNHL) have subnormal serum immunoglobulin (Ig) levels. We evaluated 28 consecutive adults (18 men, 10 women) at AS...

    Authors: Luigi F Bertoli, Dennis G Pappas, J Clayborn Barton and James C Barton

    Citation: BMC Immunology 2014 15:43

    Content type: Research article

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  40. The spleen is thought to be central in regulating the immune system, a metabolic asset involved in endocrine function. Overwhelming postsplenectomy infection leads to a mortality rate of up to 50%. However, th...

    Authors: Hai-Bo Chu, Ting-Guo Zhang, Jian-Hua Zhao, Feng-Guo Jian, Yong-Bo Xu, Tao Wang, Min Wang, Jin-Yuan Tang, Hong-Jie Sun, Kun Li, Wen-Jun Guo and Xiao-Ji Zhu

    Citation: BMC Immunology 2014 15:42

    Content type: Research article

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  41. In former studies we showed in a rat model of renal transplantation that Mesenchymal Stromal Cells (MSC) prevent acute rejection in an independent way of their endowing in the graft. In this study we investiga...

    Authors: Marilena Gregorini, Francesca Bosio, Chiara Rocca, Valeria Corradetti, Teresa Valsania, Eleonora Francesca Pattonieri, Pasquale Esposito, Giulia Bedino, Chiara Collesi, Carmelo Libetta, Francesco Frassoni, Antonio Dal Canton and Teresa Rampino

    Citation: BMC Immunology 2014 15:44

    Content type: Research article

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  42. Mammalian target of rapamycin (mTOR) inhibitors, such as sirolimus and its derivative, everolimus, are potent immunosuppressive and antiproliferative drugs. Inflammatory diseases are characterized by immunolog...

    Authors: Hugo You-Hsien Lin, Kai-Ting Chang, Chi-Chih Hung, Chang-Hung Kuo, Shang-Jyh Hwang, Hung-Chun Chen, Chih-Hsing Hung and Sheng-Fung Lin

    Citation: BMC Immunology 2014 15:37

    Content type: Research article

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  43. Alterations of B cell subset distribution have been described in the peripheral blood (PB) of rheumatoid arthritis (RA) patients, but no data are available on differences between the onset and the established ...

    Authors: Anna Laura Fedele, Barbara Tolusso, Elisa Gremese, Silvia Laura Bosello, Angela Carbonella, Silvia Canestri and Gianfranco Ferraccioli

    Citation: BMC Immunology 2014 15:28

    Content type: Research article

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  44. Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disease characterized by the presence of allergic granulomatosis and necrotizing vasculitis with eosinophilic infiltration. The etiology of EGPA i...

    Authors: Naomi Tsurikisawa, Hiroshi Saito, Chiyako Oshikata, Takahiro Tsuburai, Miyako Ishiyama, Hiroyuki Mitomi and Kazuo Akiyama

    Citation: BMC Immunology 2014 15:32

    Content type: Research article

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  45. Primary immunodeficiency diseases (PIDs) comprise a heterogeneous group of disorders mainly characterized by increased susceptibility to infections. The aims of this study were to estimate the occurrence rate ...

    Authors: Nicholas Brodszki, Göran Jönsson, Lillemor Skattum and Lennart Truedsson

    Citation: BMC Immunology 2014 15:31

    Content type: Research article

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  46. Patients with antibody deficiencies depend on the presence of a variety of antibody specificities in intravenous immunoglobulin (IVIG) to ensure continued protection against pathogens. Few studies have examine...

    Authors: Fernanda Aimée Nobre, Isabela Garrido da Silva Gonzalez, Raquel Maria Simão, Maria Isabel de Moraes Pinto and Beatriz Tavares Costa-Carvalho

    Citation: BMC Immunology 2014 15:26

    Content type: Research article

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  47. Interleukin 7 (IL-7) signals via the IL-7 receptor (IL-7R) and drives homeostatic T-cell proliferation in patients after allogeneic hematopoietic stem cell transplantation (aHSCT).

    Authors: Thomas Poiret, Lalit Rane, Mats Remberger, Birgitta Omazic, Åsa Gustafsson-Jernberg, Nalini Kumar Vudattu, Raija Ahmed, Ingemar Ernberg, Jacek Winiarski, Isabelle Magalhaes, Olle Ringden and Markus Maeurer

    Citation: BMC Immunology 2014 15:25

    Content type: Research article

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  48. Antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitis (AAV) may present with pulmonary involvement ranging from mild to life-threatening disease such as diffuse alveolar hemorrhage. There is a pau...

    Authors: Tidi M Hassan, Astrid S Hassan, Ann Igoe, Mark Logan, Cedric Gunaratnam, Noel G McElvaney and Shane J O’Neill

    Citation: BMC Immunology 2014 15:20

    Content type: Research article

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