Clinical immunology: transplants, autoimmunity and vaccines

Section edited by Lucienne Chatenoud

This section aims to publish studies on all immunological aspects of cell, organ and tissue transplantation, clinical aspects of autoimmunity and all aspects of vaccine research: development and evaluation of vaccines, immune responses to vaccines, vaccine vectors, adjuvants and immunomodulators, assays of vaccine efficacy, and clinical trials.

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  1. Research article

    Adverse events following immunization with pentavalent vaccine: experiences of newly introduced vaccine in Iran

    The most important factors that affect the incidence of vaccine-related complications are the constituent biological components of the vaccine, injection site reactions, age and sex. The aim of this study is t...

    Manoochehr Karami, Pegah Ameri, Jalal Bathaei, Zeinab Berangi, Tahereh Pashaei, Ali Zahiri, Seyed Mohsen Zahraei, Hussein Erfani and Koen Ponnet

    BMC Immunology 2017 18:42

    Published on: 23 August 2017

  2. Research article

    Blocking IL-10 signalling at the time of immunization does not increase unwanted side effects in mice

    Cancer therapeutic vaccine induced cytotoxic T cell (CTL) responses are pivotal for the killing of tumour cells. Blocking interleukin 10 (IL-10) signalling at the time of immunization increases vaccine induced...

    Guoying Ni, Zaowen Liao, Shu Chen, Tianfang Wang, Jianwei Yuan, Xuan Pan, Kate Mounsey, Shelley Cavezza, Xiaosong Liu and Ming Q. Wei

    BMC Immunology 2017 18:40

    Published on: 15 August 2017

  3. Research article

    Characteristics of the specific humoral response in patients with advanced solid tumors after active immunotherapy with a VEGF vaccine, at different antigen doses and using two distinct adjuvants

    CIGB-247, a VSSP-adjuvanted VEGF-based vaccine, was evaluated in a phase I clinical trial in patients with advanced solid tumors (CENTAURO). Vaccination with the maximum dose of antigen showed an excellent saf...

    Javier Sánchez Ramírez, Yanelys Morera Díaz, Mónica Bequet-Romero, Francisco Hernández-Bernal, Katty-Hind Selman-Housein Bernal, Ana de la Torre Santos, Eduardo Rafael Santiesteban Álvarez, Yenima Martín Bauta, Cimara H. Bermúdez Badell, Josué de la Torre Pupo, Jorge V. Gavilondo and Marta Ayala Avila

    BMC Immunology 2017 18:39

    Published on: 26 July 2017

  4. Research article

    γδTFH cells promote B cell maturation and antibody production in neuroblastoma

    Previous studies have shown that γδ TFH cells are capable of modulating antibody production in immunized and infected mouse model. In recent studies, human γδ TFH cells are shown to contribute to the activatio...

    Wenjun Mou, Wei Han, Xiaoli Ma, Xiaolin Wang, Hong Qin, Wen Zhao, Xiaoya Ren, Xi Chen, Wei Yang, Haiyan Cheng, Xisi Wang, Hui Zhang, Xin Ni, Huanmin Wang and Jingang Gui

    BMC Immunology 2017 18:36

    Published on: 7 July 2017

  5. Methodology article

    Generation of populations of antigen-specific cytotoxic T cells using DCs transfected with DNA construct encoding HER2/neu tumor antigen epitopes

    Recent fundamental and clinical studies have confirmed the effectiveness of utilizing the potential of the immune system to remove tumor cells disseminated in a patient’s body. Cytotoxic T lymphocytes (CTLs) a...

    Maria Kuznetsova, Julia Lopatnikova, Julia Khantakova, Rinat Maksyutov, Amir Maksyutov and Sergey Sennikov

    BMC Immunology 2017 18:31

    Published on: 20 June 2017

  6. Research article

    Long-term leukocyte reconstitution in NSG mice transplanted with human cord blood hematopoietic stem and progenitor cells

    Humanized mice (hu mice) are based on the transplantation of hematopoietic stem and progenitor cells into immunodeficient mice and have become important pre-clinical models for biomedical research. However, da...

    Annette Audigé, Mary-Aude Rochat, Duo Li, Sandra Ivic, Audrey Fahrny, Christina K. S. Muller, Gustavo Gers-Huber, Renier Myburgh, Simon Bredl, Erika Schlaepfer, Alexandra U. Scherrer, Stefan P. Kuster and Roberto F. Speck

    BMC Immunology 2017 18:28

    Published on: 30 May 2017

  7. Research article

    The cytokine polymorphisms affecting Th1/Th2 increase the susceptibility to, and severity of, chronic ITP

    T-helper cell type 1 (Th1) polarization in chronic immune thrombocytopenia (cITP) has been reported at the protein and mRNA levels. We evaluated the impact of Th1/Th2 cytokine and cytokine receptor functional ...

    Noriyuki Takahashi, Takayuki Saitoh, Nanami Gotoh, Yasuhiro Nitta, Lobna Alkebsi, Tetsuhiro Kasamatsu, Yusuke Minato, Akihiko Yokohama, Norifumi Tsukamoto, Hiroshi Handa and Hirokazu Murakami

    BMC Immunology 2017 18:26

    Published on: 16 May 2017

  8. Research article

    Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS)

    To assess the impact of disease activity on health-related quality of life (HRQoL) in systemic lupus erythematosus (SLE).

    Benjamin Chaigne, Carlo Chizzolini, Thomas Perneger, Marten Trendelenburg, Uyen Huynh-Do, Eric Dayer, Thomas Stoll, Johannes von Kempis and Camillo Ribi

    BMC Immunology 2017 18:17

    Published on: 28 March 2017

  9. Research Article

    Oxidative stress biomarkers and their relationship with cytokine concentrations in overweight/obese pregnant women and their neonates

    Oxidative damage present in obese/overweight mothers may lead to further oxidative stress conditions or inflammation in maternal and cord blood samples. Thirty-four pregnant women/newborn pairs were included i...

    María Hernández-Trejo, Araceli Montoya-Estrada, Yessica Torres-Ramos, Aurora Espejel-Núñez, Alberto Guzmán-Grenfell, Rosa Morales-Hernández, Maricruz Tolentino-Dolores and Estibalitz Laresgoiti-Servitje

    BMC Immunology 2017 18:3

    Published on: 7 January 2017

  10. Research article

    IL-23 plasma level is strongly associated with CMV status and reactivation of CMV in renal transplant recipients

    Cytomegalovirus seropositivity is an independent risk factor for atherosclerosis in patients with ESRD. Donor CMV seropositivity is associated with higher graft loss. Dendritic cells, macrophages and Th17 lymp...

    Mahmoud Sadeghi, Imad Lahdou, Gerhard Opelz, Arianeb Mehrabi, Martin Zeier, Paul Schnitzler and Volker Daniel

    BMC Immunology 2016 17:35

    Published on: 3 October 2016

  11. Research article

    Active immunization with human interleukin-15 induces neutralizing antibodies in non-human primates

    Interleukin-15 is an immunostimulatory cytokine overexpressed in several autoimmune and inflammatory diseases such as Rheumatoid Arthritis, psoriasis and ulcerative colitis; thus, inhibition of IL-15-induced s...

    Yunier Rodríguez-Álvarez, Yanelys Morera-Díaz, Haydee Gerónimo-Pérez, Jorge Castro-Velazco, Rafael Martínez-Castillo, Pedro Puente-Pérez, Vladimir Besada-Pérez, Eugenio Hardy-Rando, Araceli Chico-Capote, Klaudia Martínez-Cordovez and Alicia Santos-Savio

    BMC Immunology 2016 17:30

    Published on: 26 September 2016

  12. Research article

    An effective cytokine adjuvant vaccine induces autologous T-cell response against colon cancer in an animal model

    Despite recent advances in early detection and improvements in chemotherapy for colon cancer, the patients still face poor prognosis of postoperative recurrence and metastasis, the median survival for patients...

    Huanyu Ju, Wenjing Xing, Jinfeng Yang, Yang Zheng, Xiuzhi Jia, Benning Zhang and Huan Ren

    BMC Immunology 2016 17:31

    Published on: 26 September 2016

  13. Research article

    Th17 cells reflect colon submucosal pathologic changes in active eosinophilic granulomatosis with polyangiitis

    Chronic eosinophilic pneumonia (CEP) or eosinophilic gastroenteritis (EG), or both, with asthma precede the onset of eosinophilic granulomatosis with polyangiitis (EGPA) in half of all EGPA patients. It is not...

    Naomi Tsurikisawa, Chiyako Oshikata, Takahiro Tsuburai, Satoshi Sugano, Yoko Nakamura, Takuya Shimoda, Shunpei Tamama, Ken Adachi, Ayako Horita, Ikuo Saito and Hiroshi Saito

    BMC Immunology 2015 16:75

    Published on: 29 December 2015

  14. Research article

    Immunosenescence of the CD8+ T cell compartment is associated with HIV-infection, but only weakly reflects age-related processes of adipose tissue, metabolism, and muscle in antiretroviral therapy-treated HIV-infected patients and controls

    Despite effective antiretroviral therapy (ART), HIV-infected patients exhibit systemic inflammation, early onset of age-related diseases, and features of immunosenescence. The role of inflammation in the devel...

    Juliette Tavenier, Anne Langkilde, Thomas Huneck Haupt, Jens Henrik Henriksen, Frank Krieger Jensen, Janne Petersen and Ove Andersen

    BMC Immunology 2015 16:72

    Published on: 26 November 2015

  15. Research article

    Soluble RANKL expression in Lactococcus lactis and investigation of its potential as an oral vaccine adjuvant

    To initiate mucosal immune responses, antigens in the intestinal lumen must be transported into gut-associated lymphoid tissue through M cells. Recently, it has been increasingly recognized that receptor activ...

    Jeong-In Kim, Tae-Eun Park, Sushila Maharjan, Hui-Shan Li, Ho-Bin Lee, In-Seon Kim, Dachuan Piao, Jun-Yeong Lee, Chong-Su Cho, Jin-Duck Bok, Zhong-Shan Hong, Sang-Kee Kang and Yun-Jaie Choi

    BMC Immunology 2015 16:71

    Published on: 25 November 2015

  16. Research article

    Sequence conservation analysis and in silico human leukocyte antigen-peptide binding predictions for the Mtb72F and M72 tuberculosis candidate vaccine antigens

    Requisites for an efficacious tuberculosis (TB) vaccine are a minimal genomic diversity among infectious Mycobacterium tuberculosis strains for the selected antigen, and the capability to induce robust T-cell res...

    Marie-Cécile Mortier, Erik Jongert, Pascal Mettens and Jean-Louis Ruelle

    BMC Immunology 2015 16:63

    Published on: 22 October 2015

  17. Research article

    Immunoexpression of TGF-β/Smad and VEGF-A proteins in serum and BAL fluid of sarcoidosis patients

    The chronic course of pulmonary sarcoidosis can lead to lung dysfunction due to fibrosis, in which the signalling pathways TGF-β/Smad and VEGF-A may play a key role.

    Wojciech J. Piotrowski, Justyna Kiszałkiewicz, Paweł Górski, Adam Antczak, Witold Górski, Dorota Pastuszak-Lewandoska, Monika Migdalska-Sęk, Daria Domańska-Senderowska, Ewa Nawrot, Karolina H. Czarnecka, Zofia Kurmanowska and Ewa Brzeziańska-Lasota

    BMC Immunology 2015 16:58

    Published on: 6 October 2015

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