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Clinical immunology: transplants, autoimmunity and vaccines

Section edited by Lucienne Chatenoud

This section aims to publish studies on all immunological aspects of cell, organ and tissue transplantation, clinical aspects of autoimmunity and all aspects of vaccine research: development and evaluation of vaccines, immune responses to vaccines, vaccine vectors, adjuvants and immunomodulators, assays of vaccine efficacy, and clinical trials.

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  1. Content type: Research article

    Although DNA vaccine holds a great potential for cancer immunotherapy, effective long-lasting antitumoral immunity sufficient to induce durable responses in cancer patients remains to be achieved. Considering ...

    Authors: Jun Cao, Yiqi Jin, Wei Li, Bin Zhang, Yang He, Hongqiang Liu, Ning Xia, Huafeng Wei and Jian Yan

    Citation: BMC Immunology 2013 14:39

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  2. Content type: Research article

    Data regarding the quantitative expression of TCR Vβ subpopulations in children with autoimmune diseases provided interesting and sometimes conflicting results. The aim of the present study was to assess by co...

    Authors: Flora Tzifi, Maria Kanariou, Marianna Tzanoudaki, Constantinos Mihas, Evangelia Paschali, George Chrousos and Christina Kanaka-Gantenbein

    Citation: BMC Immunology 2013 14:33

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  3. Content type: Research article

    Though potentially linked to the basic physiology of stress response we still have no clear understanding of Gulf War Illness (GWI), a debilitating condition presenting complex immune, endocrine and neurologic...

    Authors: Anne Liese Smylie, Gordon Broderick, Henrique Fernandes, Shirin Razdan, Zachary Barnes, Fanny Collado, Connie Sol, Mary Ann Fletcher and Nancy Klimas

    Citation: BMC Immunology 2013 14:29

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  4. Content type: Research article

    Hepatitis C virus (HCV) is an RNA virus which has been known to cause acute and chronic necro-inflammatory disease of the liver. It is the leading cause of end-stage liver disease and hepatocellular carcinoma....

    Authors: Solomon Taye and Mekuria Lakew

    Citation: BMC Immunology 2013 14:23

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  5. Content type: Research article

    Renal injury of anti-glomerular basement membrane (GBM) disease is defined by the linear deposition of IgG along GBM and rapidly progressive glomerulonephritis. To date, the distribution of anti-GBM IgG subcla...

    Authors: Zhen Qu, Zhao Cui, Gang Liu and Ming-hui Zhao

    Citation: BMC Immunology 2013 14:19

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  6. Content type: Research article

    In sepsis, tumor necrosis factor (TNF) is the key factor triggering respiratory burst, tissue injury and disseminated coagulation. Anti-TNF strategies based on monoclonal antibodies or F(ab’)2 fragments have been...

    Authors: Rafael Bojalil, María Teresa Mata-González, Fausto Sánchez-Muñoz, Yepci Yee, Iván Argueta, Lucía Bolaños, Luis Manuel Amezcua-Guerra, Tanya Amanda Camacho-Villegas, Edna Sánchez-Castrejón, Walter Jakob García-Ubbelohde, Alexei Fedorovish Licea-Navarro, Ricardo Márquez-Velasco and Jorge Fernando Paniagua-Solís

    Citation: BMC Immunology 2013 14:17

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  7. Content type: Research article

    Interstitial lung disease (ILD) is frequently associated with collagen diseases. The prognosis of acute-onset diffuse ILD (AoDILD) occurring in collagen disease patients is very poor. Here, we investigated ser...

    Authors: Shomi Oka, Hiroshi Furukawa, Kota Shimada, Hiromi Hayakawa, Naoshi Fukui, Naoyuki Tsuchiya and Shigeto Tohma

    Citation: BMC Immunology 2013 14:9

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  8. Content type: Research article

    There is increasing evidence on complex interaction between the nervous and immune systems in patients with cerebral infarction. This study was conducted to evaluate cytotoxic function of CD8+ T lymphocytes isola...

    Authors: Gang Li, Xin Wang, Li-hong Huang, Yue Wang, Jun-jie Hao, Xia Ge and Xiao-yun Xu

    Citation: BMC Immunology 2013 14:1

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  9. Content type: Research article

    Chronic fatigue syndrome (CFS) is a clinical condition characterized by severe and disabling fatigue that is medically unexplained and lasts longer than 6 months. Although it is possible to effectively treat C...

    Authors: Hetty Prinsen, I Jolanda M de Vries, Ruurd Torensma, Jeanette M Pots, Sasja F Mulder, Carla M L van Herpen, Lammy D Elving, Gijs Bleijenberg, Foekje F Stelma and Hanneke W M van Laarhoven

    Citation: BMC Immunology 2012 13:71

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  10. Content type: Research article

    ATG has been employed to deplete T cells in several immune-mediated conditions. However, whether ATG administration affects naïve and memory T cell differently is largely unknown.

    Authors: Chang-Qing Xia, Anna V Chernatynskaya, Clive H Wasserfall, Suigui Wan, Benjamin M Looney, Scott Eisenbeis, John Williams, Michael J Clare-Salzler and Mark A Atkinson

    Citation: BMC Immunology 2012 13:70

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  11. Content type: Research article

    Elevation of soluble major histocompatibility complex class I chain-related gene A (sMICA) products in serum has been linked to tissue/organ transplantation, autoimmune diseases and some malignant disorders. C...

    Authors: Xiaoxin Jiang, Ju-Fang Huang, Zhi Huo, Qiuqui Zhang, Yan Jiang, Xiaoping Wu, Yanwen Li, Guanmin Jiang, Leping Zeng, Xiao-Xin Yan, Ping Yu and Renxian Cao

    Citation: BMC Immunology 2012 13:62

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  12. Content type: Research article

    Influenza infection may be more serious in human immunodeficiency virus (HIV)-infected individuals, therefore, vaccination against seasonal and pandemic strains is highly advised. Seasonal influenza vaccines h...

    Authors: Deborah Kelly, Kimberley Burt, Bayan Missaghi, Lisa Barrett, Yoav Keynan, Keith Fowke and Michael Grant

    Citation: BMC Immunology 2012 13:49

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  13. Content type: Research article

    IFNγ-producing CD4+CD25+Foxp3+ PBL represent a subtype of iTreg that are associated with good long-term graft outcome in renal transplant recipients and suppress alloresponses in-vitro. To study the mechanism of ...

    Authors: Volker Daniel, Mahmoud Sadeghi, Haihao Wang and Gerhard Opelz

    Citation: BMC Immunology 2012 13:47

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  14. Content type: Research article

    Decoy receptor 3 (DcR3), a member of the tumor necrosis factor receptor (TNFR) superfamily, is associated with anti-tumor immunity suppression. It is highly expressed in many tumors, and its expression can be ...

    Authors: Donghai Yang, Xin Fan, Ping Yin, Qiang Wen, Feng Yan, Sibo Yuan, Bin Liu, Guohong Zhuang and Zhongchen Liu

    Citation: BMC Immunology 2012 13:28

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  15. Content type: Research article

    Autoimmunity to collagen VII is typically associated with the skin blistering disease epidermolysis bullosa acquisita (EBA), but also occurs occasionally in patients with systemic lupus erythematosus or inflam...

    Authors: Emilia Licarete, Susanne Ganz, Martin J Recknagel, Giovanni Di Zenzo, Takashi Hashimoto, Michael Hertl, Giovanna Zambruno, Gheorghe Hundorfean, Jonas Mudter, Markus F Neurath, Leena Bruckner-Tuderman and Cassian Sitaru

    Citation: BMC Immunology 2012 13:16

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  16. Content type: Research article

    The CXCR3 receptor and its three interferon-inducible ligands (CXCL9, CXCL10 and CXCL11) have been implicated as playing a central role in directing a Th1 inflammatory response. Recent studies strongly support...

    Authors: Chung-Her Jenh, Mary Ann Cox, Long Cui, Eva-Pia Reich, Lee Sullivan, Shu-Cheng Chen, David Kinsley, Shiguang Qian, Seong Heon Kim, Stuart Rosenblum, Joseph Kozlowski, Jay S Fine, Paul J Zavodny and Daniel Lundell

    Citation: BMC Immunology 2012 13:2

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  17. Content type: Research article

    Vaccination strategies that elicit antigen-specific tolerance are needed as therapies for autoimmune disease. This study focused on whether cytokine-neuroantigen (NAg) fusion proteins could inhibit disease in ...

    Authors: Derek J Abbott, J Lori Blanchfield, David A Martinson, Sean C Russell, Najla Taslim, Alan D Curtis and Mark D Mannie

    Citation: BMC Immunology 2011 12:72

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  18. Content type: Research article

    Inflammatory bowel disease (IBD) is thought to be due to an abnormal interaction between the host immune system and commensal microflora. Within the intestinal immune system, B cells produce physiologically na...

    Authors: Caterina Defendenti, Piercarlo Sarzi-Puttini, Silvia Grosso, Annamaria Croce, Olivia Senesi, Simone Saibeni, Simona Bollani, Piero Luigi Almasio, Savino Bruno and Fabiola Atzeni

    Citation: BMC Immunology 2011 12:71

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  19. Content type: Research article

    Nonsteroidal anti-inflammatory drugs (NSAID) represent a one of the most widely used anti-inflammatory substances. Their anti-inflammatory effects are mainly based on inhibition of cyclooxygenase. The potentia...

    Authors: Saulius Paskauskas, Audrius Parseliunas, Vachtang Kerkadze, Rainer Nobiling, Jan Schmidt and Eduard Ryschich

    Citation: BMC Immunology 2011 12:64

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  20. Content type: Research article

    Vaccine literature indexing is poorly performed in PubMed due to limited hierarchy of Medical Subject Headings (MeSH) annotation in the vaccine field. Vaccine Ontology (VO) is a community-based biomedical onto...

    Authors: Junguk Hur, Zuoshuang Xiang, Eva L Feldman and Yongqun He

    Citation: BMC Immunology 2011 12:49

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  21. Content type: Research article

    At present, available pneumococcal vaccines have failed to eradicate infections caused by S. pneumoniae. Search for effective vaccine continues and some serotype independent pneumococcal proteins are considered a...

    Authors: Elisa O Vintiñi and Marcela S Medina

    Citation: BMC Immunology 2011 12:46

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