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Section edited by Olivier Garraud and James Li
This section aims to publish studies on the immune response to infection from all microbes and toxins. The section also welcomes vaccine-related research if this is related to a specific organism.
Research article
We have previously reported that interleukin-10 (IL-10) deficient dendritic cells (DCs) are potent antigen presenting cells that induced elevated protective immunity against Chlamydia. To further investigate the ...
BMC Immunology 2017 18:27
Published on: 19 May 2017
Research article
Porcine circovirus 2 (PCV2) is a small, non-enveloped DNA virus causing swine lymphocyte depletion and severe impact on the swine industry. The aim of this study was to evaluate the antigenicity and immunogeni...
BMC Immunology 2017 18:25
Published on: 15 May 2017
Methodology article
In healthy individuals, Cytomegalovirus (CMV) infection is efficiently controlled by CMV-specific cell-mediated immunity (CMI). Functional impairment of CMI in immunocompromized individuals however can lead to...
BMC Immunology 2017 18:14
Published on: 7 March 2017
Research article
Uncontrolled cytomegalovirus (CMV) replication in immunocompromised solid-organ transplant recipients is a clinically relevant issue and an indication of impaired CMV-specific cell-mediated immunity (CMI). Pri...
BMC Immunology 2017 18:15
Published on: 7 March 2017
Research article
Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes Japanese Encephalitis (JE) and Acute Encephalitis Syndrome (AES) in humans. Genotype-I (as co-circulating cases with Genotype-III) w...
BMC Immunology 2017 18:13
Published on: 6 March 2017
Research article
Lipopolysaccharide (LPS) induces acute liver injury and the complex mechanisms include the activation of toll like receptor 4 (TLR4) signaling pathway in many species. However, immuno-pathological changes duri...
BMC Immunology 2017 18:12
Published on: 27 February 2017
Research article
Tuberculosis (TB) is a major global public health problem. New treatment methods on TB are urgently demanded. In this study, Mycobacterium tuberculosis (MTB) rv2190c DNA vaccine was prepared and its immunogenicit...
BMC Immunology 2017 18:11
Published on: 27 February 2017
Research article
Patients experiencing large thermal injuries are susceptible to opportunistic infections that can delay recovery and lead to sepsis. Dendritic cells (DC) are important for the detection of pathogens and activa...
BMC Immunology 2017 18:9
Published on: 22 February 2017
Research article
Hyperactive secretion and pathogenic effects of interleukin (IL)-17 and IgA have been detected in different arthropathies. Recent evidence has revealed that TH17 cytokines regulate mucosal IgA secretion. However,...
BMC Immunology 2017 18:8
Published on: 6 February 2017
Research article
While tumor necrosis factor alpha (TNF-α) inhibitors (TNFi) and other biologics are very effective against autoimmune diseases, they can also cause infectious diseases. Therefore, it is important to clarify wh...
BMC Immunology 2017 18:7
Published on: 3 February 2017
Research article
The role of pathogen specific cellular immune responses against the eliciting pathogen in development of post-infectious chronic fatigue syndrome (PI-CFS) is not known and such studies are difficult to perform...
BMC Immunology 2017 18:5
Published on: 28 January 2017
Research article
Toxoplasma gondii is an opportunistic protozoan closely associated with AIDS and vertical transmission. T. gondii actin depolymerizing factor (TgADF) plays an important role in actin c...
BMC Immunology 2016 17:37
Published on: 6 October 2016
Research article
The purpose of this study was to characterize specific cytotoxic T-cell (CTL) responses in men who have sex with men (MSM) subjects infected with the human immunodeficiency virus type 1 (HIV-1) CRF01_AE subtyp...
BMC Immunology 2016 17:28
Published on: 30 August 2016
Research article
The lung is exposed to airborne fungal spores, and fungi that colonize the oral cavity such as Candida albicans, but does not develop disease to opportunistic fungal pathogens unless the immune system is compromi...
BMC Immunology 2016 17:27
Published on: 8 August 2016
Research article
Serglycin proteoglycans are essential for maturation of secretory granules and for the correct granular storage of cationic proteases in hematopoietic cells, e.g. mast cells. However, little is known about the...
BMC Immunology 2016 17:15
Published on: 8 June 2016
Research article
Cystic echinococcosis (CE), caused by infection with Echinococcus granulosus larvae, is a potentially life-threatening disease in humans. Anaphylactic shock caused by CE is very dangerous, and is highly prevalent...
BMC Immunology 2016 17:4
Published on: 11 March 2016
Research article
Streptococcus pneumoniae, a major causative bacterial pathogen of community-acquired pneumonia, possesses a thick polysaccharide capsule. Host defense against this bacterium is mediate...
BMC Immunology 2016 17:1
Published on: 5 January 2016
Research article
The innate immune response of urinary tract is critically important in the defense to microbial attack. Toll-like receptor 4 (TLR4) controls initial mucosal response to uropathogenic Escherichia coli (UPEC). Howe...
BMC Immunology 2015 16:73
Published on: 3 December 2015
Research article
Ulcerative colitis, an inflammatory bowel disease, is associated with the massive infiltration of neutrophils. Although the initial infiltration of neutrophils is beneficial for killing bacteria, it is presume...
BMC Immunology 2015 16:64
Published on: 23 October 2015
Research article
Ebola is a Filovirus (FV) that induces a highly communicable and deadly hemorrhagic fever. Currently, there are no approved vaccines to treat FV infections. Protection from FV infection requires cell mediated ...
BMC Immunology 2015 16:59
Published on: 6 October 2015
