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Inflammation, allergy and hypersensitivity

This section aims to publish studies on all types of hypersensitivity, allergens and processes associated with inflammation. This section includes, but is not limited to, studies looking at cytokines and cytokine receptors in allergy, eosinophils, mast cells, chemokines and their receptors, as well as specific diseases and their therapy.

  1. Content type: Research article

    Proinflammatory genes are highly expressed in several metabolic disorders associated with obesity. But it is not clarified whether gene expression levels and downstream inflammatory markers are related to the ...

    Authors: Parichehr Amiri, Behzad Baradaran, Maryam Saghafi-Asl, Mahsa Naghizadeh, Dariush Shanehbandi, Nahid Karamzad and Sepideh Zununi Vahed

    Citation: BMC Immunology 2019 20:23

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  2. Content type: Research article

    Mouse models have been extremely valuable in identifying the fundamental mechanisms of airway inflammation that underlie human allergic asthma. Several models are commonly used, employing different methods and...

    Authors: Evelyn J. Hyde, Kirsty A. Wakelin, Naomi J. Daniels, Sayani Ghosh and Franca Ronchese

    Citation: BMC Immunology 2019 20:18

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  3. Content type: Research article

    In coeliac disease, ingestion of gluten induces the production of transglutaminase 2 (TG2)-targeted autoantibodies by TG2-specific plasma cells present at high frequency in the small intestinal mucosa in untre...

    Authors: Minna Hietikko, Outi Koskinen, Kalle Kurppa, Kaija Laurila, Päivi Saavalainen, Teea Salmi, Tuire Ilus, Heini Huhtala, Katri Kaukinen and Katri Lindfors

    Citation: BMC Immunology 2018 19:36

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  4. Content type: Research article

    Tumor-Associated Neutrophils (TANs) may be able to induce lymphangiogenesis and angiogenesis, although the detailed roles of TANs remain unclear. The Neutrophil-Lymphocyte Ratio (NLR) is an inflammation-based ...

    Authors: Soichiro Hiramatsu, Hiroaki Tanaka, Junya Nishimura, Chie Sakimura, Tatsuro Tamura, Takahiro Toyokawa, Kazuya Muguruma, Masakazu Yashiro, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Immunology 2018 19:13

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  5. Content type: Research article

    Major depressive disorder (MDD) is a common psychiatric complication of HIV/AIDS. While considerable research has been undertaken to understand the psychosocial risk factors of MDD, there is a paucity of data ...

    Authors: Kenneth Musinguzi, Andrew Obuku, Noeline Nakasujja, Harriet Birabwa, Juliet Nakku, Jonathan Levin and Eugene Kinyanda

    Citation: BMC Immunology 2018 19:1

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  6. Content type: Research article

    Chemokines and their cognate receptors play important role in the control of leukocyte chemotaxis, HIV entry and other inflammatory diseases. Developing an effcient method to investigate the functional express...

    Authors: Baosheng Ge, Jiqiang Li, Zhijin Wei, Tingting Sun, Yanzhuo Song and Naseer Ullah Khan

    Citation: BMC Immunology 2017 18:54

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  7. Content type: Research article

    Some patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) also have positivity of rheumatoid factor (RF). However, the clinical significance of this occurrence remains unknown i...

    Authors: Shinji Watanabe, Takahisa Gono, Kumiko Nishina, Naohiro Sugitani, Eri Watanabe, Hiroki Yabe and Chihiro Terai

    Citation: BMC Immunology 2017 18:53

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  8. Content type: Research article

    To investigate the impact of miRNA (microRNA) on hepatic oxidative stress damage under the human mesenchymal stem cell conditioned medium (MSC-CM) and explore the roles of the beta-1 adrenergic receptor (ADRB1...

    Authors: Xuejing Xu, Dong Li, Xue Li, Qing Shi and Xiuli Ju

    Citation: BMC Immunology 2017 18:51

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  9. Content type: Research article

    To investigate natural killer (NK) cell activity, circulating cytokine level and peripheral blood mononuclear cell (PBMC) cytokine production status in critically ill patients.

    Authors: Minkyung Kim, Minjoo Kim, Hana Jeong, Jey Sook Chae, Young Sam Kim, Jae Gil Lee, Younsoo Cho and Jong Ho Lee

    Citation: BMC Immunology 2017 18:48

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  10. Content type: Research article

    Interleukin-9 (IL-9) was reported as an active participant in the pathogenesis of allergic asthma. This study aimed to investigate the major source ofIL-9 and its effect on interferon γ (IFN-γ) and immunoglobu...

    Authors: Lei Jia, Ying Wang, Jiangping Li, Sha Li, Yannan Zhang, Juan Shen, Weiping Tan and Changyou Wu

    Citation: BMC Immunology 2017 18:38

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  11. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is a common, chronic liver disease worldwide. Recent studies have shown that T helper (Th) 17 and regulatory T (Treg) cells play critical roles in various disorders of...

    Authors: Beihui He, Liyan Wu, Wei Xie, Yitong Shao, Jianping Jiang, Zhenzhong Zhao, Maoxiang Yan, Zhiyun Chen and Dawei Cui

    Citation: BMC Immunology 2017 18:33

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  12. Content type: Research article

    Allergy to cat epithelia is highly prevalent, being the major recommendation for allergy sufferers its avoidance. However, this is not always feasible. Allergen specific immunotherapy is therefore recommended ...

    Authors: María Morales, Mayte Gallego, Victor Iraola, Marta Taulés, Eliandre de Oliveira, Raquel Moya and Jerónimo Carnés

    Citation: BMC Immunology 2017 18:10

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  13. Content type: Research article

    Fetuin-A/AHSH is a novel hepatokine that acts as a vascular calcification inhibitor and as an endogenous TLR-4 ligand. Fetuin-A may act as a positive or negative acute phase protein (APP) in disease conditions...

    Authors: Sardar Sindhu, Nadeem Akhter, Steve Shenouda, Ajit Wilson and Rasheed Ahmad

    Citation: BMC Immunology 2016 17:33

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  14. Content type: Research article

    The mouse strain BALB/c deficient in IL-1 receptor antagonist protein (Il-1ra) develops spontaneous arthritis disease (SAD) while the strain DBA/1 IL1rn -/- with the same deficiency doe...

    Authors: Xiaoyun Liu, Yan Jiao, Yanhong Cao, Nan Deng, Yonghui Ma, Karen A. Hasty, Andrew Kang, Hong Chen, John M. Stuart and Weikuan Gu

    Citation: BMC Immunology 2016 17:25

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  15. Content type: Research article

    Mast cells are hematopoietically derived cells that play a role in inflammatory processes such as allergy, as well as in the immune response against pathogens by the selective and rapid release of preformed an...

    Authors: Valéria Cintra Barbosa-Lorenzi, Nerry Tatiana Cecilio, Patricia Andressa de Almeida Buranello, Maria Cristina Pranchevicius, Maria Helena S. Goldman, Gabriela Pereira-da-Silva, Maria Cristina Roque-Barreira, Maria Célia Jamur and Constance Oliver

    Citation: BMC Immunology 2016 17:22

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  16. Content type: Research article

    In genetically modified (GM) crops there is a risk that the inserted genes may introduce new allergens and/or adjuvants into the food and feed chain. The MON810 maize, expressing the insecticidal Cry1Ab toxin,...

    Authors: Monica Andreassen, Thomas Bøhn, Odd-Gunnar Wikmark, Johanna Bodin, Terje Traavik, Martinus Løvik and Unni Cecilie Nygaard

    Citation: BMC Immunology 2016 17:10

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  17. Content type: Research article

    Galectin-3 is known to be a lectin that plays an important role in inflammatory processes, acting as pro-inflammatory mediator in activation and migration of neutrophils and macrophages, as well as in the phag...

    Authors: Camila Brand, Thayse Pinheiro da Costa, Emerson Soares Bernardes, Camila Maria Longo Machado, Leonardo Rodrigues Andrade, Roger Chammas, Felipe Leite de Oliveira and Márcia Cury El-Cheikh

    Citation: BMC Immunology 2015 16:68

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  18. Content type: Research article

    Several inflammatory cytokines play a key part in the induction of osteoporosis. Until now, involvement of the Th2 cytokine interleukin-31 (IL-31) in osteoporosis hadn’t yet been studied. IL-31 is a proinflamm...

    Authors: Lia Ginaldi, Massimo De Martinis, Fedra Ciccarelli, Salvatore Saitta, Selene Imbesi, Carmen Mannucci and Sebastiano Gangemi

    Citation: BMC Immunology 2015 16:60

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  19. Content type: Research article

    Gulf War Illness (GWI) is a clinically heterogeneous chronic condition that affects many veterans of the 1990–1991 Persian Gulf War. One of the most prevalent and debilitating symptoms of GWI is abnormal fatig...

    Authors: Luke Parkitny, Stephanie Middleton, Katharine Baker and Jarred Younger

    Citation: BMC Immunology 2015 16:57

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  20. Content type: Research article

    Pepsin-trypsin resistant gliadin (PT-gliadin) promotes intestinal tissue inflammation and increases paracellular permeability of immunogenic gliadin peptides into the lamina propria. This leads to the complica...

    Authors: Naiyana Gujral, Ju Won Suh and Hoon H. Sunwoo

    Citation: BMC Immunology 2015 16:41

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  21. Content type: Research article

    The extracellular domains of cytokine receptors are released during inflammation, but little is known about the shedding of Toll-like receptors (TLR) and whether they can be used as diagnostic biomarkers.

    Authors: Jaap ten Oever, Matthijs Kox, Frank L van de Veerdonk, Khutso M Mothapo, Adriana Slavcovici, Tim L Jansen, Lieke Tweehuysen, Evangelos J Giamarellos-Bourboulis, Peter M Schneeberger, Peter C Wever, Monique Stoffels, Anna Simon, Jos WM van der Meer, Melissa D Johnson, Bart-Jan Kullberg, Peter Pickkers…

    Citation: BMC Immunology 2014 15:55

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  22. Content type: Research article

    Long-acting β2 adrenergic agonists (LABAs) are commonly used combined with inhaled corticosteroids (ICS) to treat asthmatic patients. Previous reports suggest that LABAs have an anti-inflammatory effect in bro...

    Authors: Go Kato, Koichiro Takahashi, Hiroki Tashiro, Keigo Kurata, Hideharu Shirai, Shinya Kimura and Shinichiro Hayashi

    Citation: BMC Immunology 2014 15:39

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  23. Content type: Research article

    Development and function of tissue resident mast cells (MCs) is tightly controlled by various cytokines, most of which belong to the typical T helper (Th) 2-type cytokines such as IL-3 and IL-4. The effects of...

    Authors: Gernot Sellge, Miriam Barkowsky, Sigrid Kramer, Thomas Gebhardt, Leif E Sander, Axel Lorentz and Stephan C Bischoff

    Citation: BMC Immunology 2014 15:27

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  24. Content type: Research article

    Allergen immunotherapy (SIT) is the only treatment for allergic disease capable of modifying disease long term. To reduce the risk of anaphylaxis from SIT, allergen-extracts have been modified by polymerisatio...

    Authors: Zoe L Urry, David F Richards, Cheryl Black, Maria Morales, Jerónimo Carnés, Catherine M Hawrylowicz and Douglas S Robinson

    Citation: BMC Immunology 2014 15:21

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  25. Content type: Research article

    Recent studies have demonstrated a protective role for IL-33 against obesity-associated inflammation, atherosclerosis and metabolic abnormalities. IL-33 promotes the production of T helper type 2 (Th2) cytokin...

    Authors: Amal Hasan, Fahad Al-Ghimlas, Samia Warsame, Asma Al-Hubail, Rasheed Ahmad, Abdullah Bennakhi, Monira Al-Arouj, Kazem Behbehani, Mohammed Dehbi and Said Dermime

    Citation: BMC Immunology 2014 15:19

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  26. Content type: Research article

    The role of M2 polarized macrophages (MΦ) during the allergic airway inflammation has been discussed in various animal models. However, their presence and relevance during the chronic and acute phase of allerg...

    Authors: Carla Winkler, Lena Witte, Natali Moraw, Conny Faulenbach, Meike Müller, Olaf Holz, Frank Schaumann and Jens M Hohlfeld

    Citation: BMC Immunology 2014 15:12

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  27. Content type: Research article

    Interleukin-10 (IL-10) has an important anti-inflammatory and immunoregulatory function, and its expression is negatively correlated with the development and severity of allergic rhinitis (AR). However, the in...

    Authors: Shui-Bin Wang, Yu-Qin Deng, Jie Ren, Bo-Kui Xiao, Zheng Liu and Ze-Zhang Tao

    Citation: BMC Immunology 2014 15:9

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  28. Content type: Research article

    Allergen recognition by dendritic cells (DCs) is a key event in the allergic cascade leading to production of IgE antibodies. C-type lectins, such as the mannose receptor and DC-SIGN, were recently shown to pl...

    Authors: Inas K Sharquie, Abeer Al-Ghouleh, Patricia Fitton, Mike R Clark, Kathryn L Armour, Herb F Sewell, Farouk Shakib and Amir M Ghaemmaghami

    Citation: BMC Immunology 2013 14:54

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  29. Content type: Research article

    Short dimeric or mulitmeric peptides derived from a highly conserved stretch of amino acids from gammaretroviral envelope proteins has been found to have immunosuppressive properties in vitro. Here we test the hy...

    Authors: Martin Tolstrup, Claus Johansen, Lars Toft, Finn S Pedersen, Anne Funding, Shervin Bahrami, Lars Iversen, Lars Østergaard and Mogens Duch

    Citation: BMC Immunology 2013 14:51

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  30. Content type: Research article

    Allergic sensitisation has been ascribed to a dysregulated relationship between allergen-specific Th1, Th2 and regulatory T cells. We sought to utilise our short-term CD154 detection method to further analyse ...

    Authors: Karen A Smith, Nicola J Gray, Femi Saleh, Elizabeth Cheek, Anthony J Frew, Florian Kern and Michael D Tarzi

    Citation: BMC Immunology 2013 14:49

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  31. Content type: Research article

    Impaired diabetic wound healing occurs as a consequence of excessive reactive oxygen species (ROS) and inflammatory cytokine production. We previously found that whey protein (WP) was able to normally regulate...

    Authors: Hossam Ebaid, Osama M Ahmed, Ayman M Mahmoud and Rasha R Ahmed

    Citation: BMC Immunology 2013 14:31

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  32. Content type: Research article

    Airway inflammation is mainly mediated by T helper 2 cells (Th2) that characteristically produce interleukin (IL)-4, IL-5, and IL-13. Epidemiological studies have revealed an inverse association between the di...

    Authors: Jinhong Wu, Yanjie Zhang, Qi Liu, Wenwei Zhong and Zhenwei Xia

    Citation: BMC Immunology 2013 14:28

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  33. Content type: Research article

    Allergic sensitisation has been ascribed to a dysregulated relationship between allergen-specific Th1, Th2 and regulatory T cells. We hypothesised that the relationship between these T cell subsets could be be...

    Authors: Karen A Smith, Nicola J Gray, Elizabeth Cheek, Femi Saleh, Jo Lavender, Anthony J Frew, Florian Kern and Michael D Tarzi

    Citation: BMC Immunology 2013 14:14

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  34. Content type: Research article

    Blomia tropicalis is a dust mite and an important source of allergens in tropical regions. Up to now, the assays to diagnose atopy to this mite use whole body extract as antigens. However, anti-B. tropicalis IgE ...

    Authors: Kellyanne dos Anjos Carvalho, Osvaldo Pompílio de Melo-Neto, Franklin Barbalho Magalhães, João Carlos Marques Ponte, Filipe Adriano Borba Felipe, Mariese Conceição Alves dos Santos, Givaneide dos Santos Lima, Álvaro Augusto Cruz, Carina Silva Pinheiro, Lain Carlos Pontes-de-Carvalho and Neuza Maria Alcantara-Neves

    Citation: BMC Immunology 2013 14:11

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  35. Content type: Research article

    Oral bovine colostrum prophylaxis accelerates the recovery of dextran sulfate sodium (DSS)-induced colitis. In the present study the beneficial effects on acute intestinal inflammation of two major colostral c...

    Authors: Peggy Bodammer, Elisabeth Zirzow, Sebastian Klammt, Claudia Maletzki and Claus Kerkhoff

    Citation: BMC Immunology 2013 14:10

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  36. Content type: Research article

    Glucocorticoids are widely regarded as the most effective treatment for asthma. However, the direct impact of glucocorticoids on the innate immune system and antibacterial host defense during asthma remain unc...

    Authors: Peng Wang, Xiaoyun Wang, Xiaoqiong Yang, Zhigang Liu, Min Wu and Guoping Li

    Citation: BMC Immunology 2013 14:7

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  37. Content type: Research article

    Allergic skin inflammation such as atopic dermatitis (AD), which is characterized by pruritus and inflammation, is regulated partly through the activity of regulatory T cells (Tregs). Tregs play key roles in t...

    Authors: Sang-Chul Han, Gyeoung-Jin Kang, Yeong-Jong Ko, Hee-Kyoung Kang, Sang-Wook Moon, Yong-Seok Ann and Eun-Sook Yoo

    Citation: BMC Immunology 2012 13:44

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  38. Content type: Research article

    Mugwort pollen allergens represent the main cause of pollinosis in late summer. The major allergen, Art v 1, contains only one single immunodominant, solely HLA-DR-restricted T cell epitope (Art v 125-36). The fr...

    Authors: Bernhard Knapp, Gottfried Fischer, Dries Van Hemelen, Ingrid Fae, Bernard Maillere, Christof Ebner, Wolfgang Schreiner, Barbara Bohle and Beatrice Jahn-Schmid

    Citation: BMC Immunology 2012 13:43

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  39. Content type: Research article

    Antigen-specific immunotherapy (SIT) has been widely practiced in treating allergic diseases such as asthma. However, this therapy may induce a series of allergic adverse events during treatment. Peptide immun...

    Authors: Wen Su, Wenwei Zhong, Yanjie Zhang and Zhenwei Xia

    Citation: BMC Immunology 2012 13:34

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  40. Content type: Research article

    The IL-4 receptor α (IL-4Rα) chain has a broad expression pattern and participates in IL-4 and IL-13 signaling, allowing it to influence several pathological components of allergic lung inflammation. We previo...

    Authors: Andrew Q Ford, Preeta Dasgupta, Irina Mikhailenko, Elizabeth MP Smith, Nancy Noben-Trauth and Achsah D Keegan

    Citation: BMC Immunology 2012 13:6

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  41. Content type: Research article

    The genus Micrurus, coral snakes (Serpentes, Elapidae), comprises more than 120 species and subspecies distributed from the south United States to the south of South America. Micrurus snake bites can cause death ...

    Authors: Gabriela D Tanaka, Giselle Pidde-Queiroz, Maria de Fátima D Furtado, Carmen van den Berg and Denise V Tambourgi

    Citation: BMC Immunology 2012 13:4

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  42. Content type: Research article

    Pulmonary hypertension (PH) refers to a spectrum of diseases with elevated pulmonary artery pressure. Pulmonary arterial hypertension (PAH) is a disease category that clinically presents with severe PH and tha...

    Authors: Moloud Rabieyousefi, Pejman Soroosh, Kimio Satoh, Fumiko Date, Naoto Ishii, Masahiro Yamashita, Masahiko Oka, Ivan F McMurtry, Hiroaki Shimokawa, Masato Nose, Kazuo Sugamura and Masao Ono

    Citation: BMC Immunology 2011 12:67

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  43. Content type: Research article

    CD4+ T helper type 2 (TH2) cells, their cytokines IL-4, IL-5 and IL-13 and the transcription factor STAT6 are known to regulate various features of asthma including lung inflammation, mucus production and airway ...

    Authors: Preeta Dasgupta, Svetlana P Chapoval, Elizabeth P Smith and Achsah D Keegan

    Citation: BMC Immunology 2011 12:60

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  44. Content type: Research article

    The balancing functions of pro/anti-inflammatory mediators of the complex innate responses have been investigated in a variety of experimental inflammatory settings. Annexin-A1 (AnxA1) is one mediator of endog...

    Authors: Amílcar S Damazo, André LF Sampaio, Cintia MAG Nakata, Roderick J Flower, Mauro Perretti and Sonia M Oliani

    Citation: BMC Immunology 2011 12:59

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  45. Content type: Research article

    Airway hyperresponsiveness (AHR) is one of the important traits that characterize bronchial asthma. Goishi tea is a post-heating fermented tea that has been reported to have higher free radical scavenging acti...

    Authors: Ryoji Hirota, Nlandu R Ngatu, Mitsuhiko Miyamura, Hiroyuki Nakamura and Narufumi Suganuma

    Citation: BMC Immunology 2011 12:45

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  46. Content type: Research article

    Ganoderma lucidum-derived polysaccharide (PS-G) can rapidly and effectively promote the activation and maturation of immature dendritic cells (DCs), suggesting that PS-G possesses the capacity to regulate immune ...

    Authors: Rong-Hwa Jan, Teng-Yi Lin, Ya-Chun Hsu, Shiuh-Sheng Lee, Shih-Yen Lo, Mingi Chang, Li-Kuang Chen and Yu-Li Lin

    Citation: BMC Immunology 2011 12:31

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  47. Content type: Research article

    Heat shock proteins (Hsp) are ubiquitously synthesised in virtually all species and it is hypothesised that they might have beneficial health effects. Recent studies have identified circulating Hsp as an impor...

    Authors: Rose Njemini, Ivan Bautmans, Oscar O Onyema, Katrien Van Puyvelde, Christian Demanet and Tony Mets

    Citation: BMC Immunology 2011 12:24

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