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  1. In asthma and other allergic disorders, the activation of mast cells by IgE and antigen induces the cells to release histamine and other mediators of inflammation, as well as to produce certain cytokines and c...

    Authors: Koichi Sayama, Maximilian Diehn, Kentaro Matsuda, Carolina Lunderius, Mindy Tsai, See-Ying Tam, David Botstein, Patrick O Brown and Stephen J Galli

    Citation: BMC Immunology 2002 3:5

    Content type: Research article

    Published on:

  2. Gene transfer studies in primary T cells have suffered from the limitations of conventional viral transduction or transfection techniques. Replication-defective adenoviral vectors are an attractive alternative...

    Authors: Vincent Hurez, Robin Dzialo-Hatton, James Oliver, R James Matthews and Casey T Weaver

    Citation: BMC Immunology 2002 3:4

    Content type: Methodology article

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  3. Macrophages, upon encounter with micro-organisms or stimulated by cytokines, produce various effector molecules aimed at destroying the foreign agents and protecting the organism. Reactive oxygen species (ROS)...

    Authors: Pierre-Jacques Ferret, Emmanuelle Soum, Olivier Negre and Didier Fradelizi

    Citation: BMC Immunology 2002 3:3

    Content type: Research article

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  4. T helper epitopes are necessary for the induction of high titers of antigen-specific IgG antibodies. We are interested in the epitope modification of intact proteins as a method to enhance their immunogenicity...

    Authors: Jeanette M Mucha, Marcia M Stickler, AJ Poulose, Grant Ganshaw, Mae Saldajeno, Kathy Collier, Manley T Huang and Fiona A Harding

    Citation: BMC Immunology 2002 3:2

    Content type: Research article

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  5. Intrathymic development and selection of the T lymphocyte repertoire is restricted by the interactions of the T cell antigen receptor and CD4 or CD8 co-receptors with self major histocompatibility complex mole...

    Authors: Hector Martinez-Valdez, Vicente Madrid-Marina and Amos Cohen

    Citation: BMC Immunology 2002 3:1

    Content type: Research article

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  6. Macrophages sense microorganisms through activation of members of the Toll-like receptor family, which initiate signals linked to transcription of many inflammation associated genes. In this paper we examine w...

    Authors: David A Hume, David M Underhill, Matthew J Sweet, Adrian O Ozinsky, Foo Y Liew and Alan Aderem

    Citation: BMC Immunology 2001 2:11

    Content type: Research article

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  7. T cells from HIV+ and aged individuals show parallels in terms of suppressed proliferative activity and interleukin-2 (I1-2) production and an increased number of CD8+ CD28- T cells. In order to compare cytokine ...

    Authors: Edward H Eylar, Carmen E Lefranc, Yasuhiro Yamamura, Ineabely Báez, Sol Luis Colón-Martinez, Nayra Rodriguez and T B Breithaupt

    Citation: BMC Immunology 2001 2:10

    Content type: Research article

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  8. The immune system is particularly sensitive to stress. Although acute stress generally has positive effects, chronic stress typically provokes immunosuppression. The elucidation of the mechanisms involved in i...

    Authors: Lourdes Domínguez-Gerpe and Manuel Rey-Méndez

    Citation: BMC Immunology 2001 2:7

    Content type: Research article

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  9. The identification of antigens on human DC has been a very difficult and elusive task because of the lack of appropriate reagents. Therefore, we evaluated by flow cytometry a panel of mAb that recognize antige...

    Authors: Rafael Nunez and Luis Filgueira

    Citation: BMC Immunology 2001 2:6

    Content type: Research article

    Published on:

  10. Increasing evidence suggests that the effect of HLA-E on Natural Killer (NK) cell activity can be affected by the nature of the peptides bound to this non-classical, MHC class Ib molecule. However, its reduced...

    Authors: James Stevens, Etienne Joly, John Trowsdale and Geoffrey W Butcher

    Citation: BMC Immunology 2001 2:5

    Content type: Research article

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  11. Bruton's tyrosine kinase (Btk) is essential for B cell development and function. Mutations of Btk elicit X-linked agammaglobulinemia in humans and X-linked immunodeficiency in the mouse. Btk has been proposed ...

    Authors: Michael G Tomlinson, Douglas B Woods, Martin McMahon, Matthew I Wahl, Owen N Witte, Tomohiro Kurosaki, Joseph B Bolen and James A Johnston

    Citation: BMC Immunology 2001 2:4

    Content type: Research article

    Published on:

  12. The Tec family kinases are implicated in signaling from lymphocyte antigen receptors and are activated following phosphorylation by Src kinases. For most Tec kinases, this activation requires an interaction be...

    Authors: Mario Chamorro, Michael J Czar, Jayanta Debnath, Genhong Cheng, Michael J Lenardo, Harold E Varmus and Pamela L Schwartzberg

    Citation: BMC Immunology 2001 2:3

    Content type: Research article

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  13. Lymphoid tissues constitute basic structures where specific immune responses take place. This leads to the development of germinal centres (GCs), migration of cells and the generation of memory cells. Here, we...

    Authors: Berta Vidal-Rubio, Marta Sanchez-Carril, Josefina Oliver-Morales, África González-Femandez and Francisco Gambón-Deza

    Citation: BMC Immunology 2001 2:2

    Content type: Research article

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  14. Peroxynitrite is increasingly proposed as a contributor to defence system in marine bivalve. It can be formed by combinaison of superoxide and nitric oxide, and can react with tyrosine residues of proteins giv...

    Authors: Jean Torreilles and Bernard Romestand

    Citation: BMC Immunology 2001 2:1

    Content type: Research article

    Published on:

  15. NFATp is one member of a family of transcriptional activators whose nuclear accumulation and hence transcriptional activity is regulated in mammalian cells. Human NFATp exists as a phosphoprotein in the cytopl...

    Authors: Loree J Kim, Heather A Ferguson, Anita G Seto and James A Goodrich

    Citation: BMC Immunology 2000 1:1

    Content type: Research article

    Published on:

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