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1169 result(s) for 'immunology' within BMC Immunology

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  1. Primary immunodeficiences (PIDs) are a group of chronic, serious disorders in which the immune response is insufficient. In consequence, it leads to an increased susceptibility to infections. Up to date, there ar...

    Authors: Karolina Pieniawska-Śmiech, Kamil Bar, Mateusz Babicki, Karol Śmiech and Aleksandra Lewandowicz-Uszyńska
    Citation: BMC Immunology 2020 21:42
    Content type: Research article Published on:

  2. A long-term existing schistosome infection can aid in maintaining immuno-homeostasis, thus providing protection against various types of autoimmune diseases to the infected host. Such benefits have often been ...

    Authors: YunKun He, Jia Li, WenJia Zhuang, Lan Yin, ChunXia Chen, Jun Li, FengLi Chi, YanShuang Bai and Xiao-Ping Chen
    Citation: BMC Immunology 2010 11:28
    Content type: Research article Published on:

  4. Multiple myeloma (MM) is a clonal B-cell disorder with many immunological disturbances. The aim of this work was to assess whether some of food antigens contribute to the imbalance of immune response by screen...

    Authors: Zorica Juranic, Jelena Radic, Aleksandra Konic-Ristic, Svetislav Jelic, Biljana Mihaljevic, Ivan Stankovic, Suzana Matkovic, Irina Besu and Dušica Gavrilović
    Citation: BMC Immunology 2008 9:22
    Content type: Research article Published on:

  5. Chronic fatigue syndrome (CFS) is a clinical condition characterized by severe and disabling fatigue that is medically unexplained and lasts longer than 6 months. Although it is possible to effectively treat C...

    Authors: Hetty Prinsen, I Jolanda M de Vries, Ruurd Torensma, Jeanette M Pots, Sasja F Mulder, Carla M L van Herpen, Lammy D Elving, Gijs Bleijenberg, Foekje F Stelma and Hanneke W M van Laarhoven
    Citation: BMC Immunology 2012 13:71
    Content type: Research article Published on:

  6. Up to 40% of HIV-infected individuals receiving Highly Active Antiretroviral Therapy (HAART) have poor CD4+ T-cell recovery. The role of natural killer (NK) cells in immune recovery during HAART is not well un...

    Authors: Lois Bayigga, Rose Nabatanzi, Prossy Naluyima Sekiziyivu, Harriet Mayanja-Kizza, Moses R Kamya, Andrew Kambugu, Joseph Olobo, Agnes Kiragga, Sam Kirimunda, Moses Joloba and Damalie Nakanjako
    Citation: BMC Immunology 2014 15:2
    Content type: Research article Published on:

  7. Resistin, a member of adipokine family, is known to be involved in the modulation of immune responses including inflammatory activity. Interestingly, resistin is secreted by adipocytes in mice and rats whereas...

    Authors: Young Min Son, Sung Min Ahn, Gi Rak Kim, Yang Soo Moon, Sang Hoon Kim, Yeong-Min Park, Woon Kyu Lee, Tae Sun Min, Seung Hyun Han and Cheol-Heui Yun
    Citation: BMC Immunology 2010 11:33
    Content type: Research article Published on:

  8. Common Variable Immunodeficiency (CVID) is a primary immunodeficiency syndrome resulting in recurrent infections, autoimmunity, and granulomatous manifestations.

    Authors: Hossein Esmaeilzadeh, Armita Jokar-Derisi, Amir Hossein Hassani, Reza Yazdani, Samaneh Delavari, Hassan Abolhassani, Negar Mortazavi and Aida Askarisarvestani
    Citation: BMC Immunology 2023 24:9
    Content type: Research Published on:

  9. Oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODN) are known to exert a strong adjuvant effect on Th1 immune responses. Although several genes have been reported, no comprehensive study of the ...

    Authors: Atsushi Kato, Toshiki Homma, Jonathan Batchelor, Noriko Hashimoto, Shosuke Imai, Hiroshi Wakiguchi, Hirohisa Saito and Kenji Matsumoto
    Citation: BMC Immunology 2003 4:8
    Content type: Research article Published on:

  11. Most HIV-infected subjects exhibit a progressive rise in CD4 T-cell counts after initiation of highly active antiretroviral therapy (HAART). However, a subset of individuals exhibit very poor CD4 T-cell recove...

    Authors: Damalie Nakanjako, Isaac Ssewanyana, Rose Nabatanzi, Agnes Kiragga, Moses R Kamya, Huyen Cao and Harriet Mayanja-Kizza
    Citation: BMC Immunology 2013 14:26
    Content type: Research article Published on:

  12. Understanding immune mechanisms, particularly the role of innate immune markers during latent TB infection remains elusive. The main objective of this study was to evaluate mRNA gene expression patterns of tol...

    Authors: Birhan Alemnew, Soren T. Hoff, Tamrat Abebe, Markos Abebe, Abraham Aseffa, Rawleigh Howe and Liya Wassie
    Citation: BMC Immunology 2021 22:9
    Content type: Research Published on:

  13. CD4+CD25+Foxp3+ regulatory T (Treg) cell-mediated immunosuppression is an essential mechanism of rheumatoid arthritis (RA). However, little is known regarding the specific role of CD4+CD25−Foxp3+ Treg cells in RA...

    Authors: Bomiao Ju, Li Zhu, Jing Wang, Jian Zheng, Zhiming Hao, Jing Luo, Jing Zhang, Nan Hu, Qi An, Xiuyuan Feng, Yongwei Huo and Lan He
    Citation: BMC Immunology 2022 23:41
    Content type: Research Published on:

  14. Obesity is correlated with worse drug responses and high disease activity in patients with rheumatoid arthritis (RA). Interleukin (IL)-35 is a novel anti-inflammatory cytokine that mainly produced by regulator...

    Authors: Yuxuan Li, Yang Jie, Xiaofei Wang and Jing Lu
    Citation: BMC Immunology 2021 22:42
    Content type: Research article Published on:

  15. T cell immunoglobulin and mucin domain-containing-3 (Tim-3) is a negative regulator expressed on T cells, and is also expressed on natural killer (NK) cells. The function of Tim-3 chiefly restricts IFNγ-produc...

    Authors: Xiaowen Yu, Bin Lang, Xi Chen, Yao Tian, Shi Qian, Zining Zhang, Yajing Fu, Junjie Xu, Xiaoxu Han, Haibo Ding and Yongjun Jiang
    Citation: BMC Immunology 2021 22:25
    Content type: Research article Published on:

  16. Innate immune cells play a crucial role in the pathophysiology of rheumatoid arthritis (RA) via release of cytokines. Small-molecule inhibitors of Janus kinases (JAKi) are clinically efficacious in patients wi...

    Authors: Yuya Fujita, Naoki Matsuoka, Jumpei Temmoku, Makiko Furuya-Yashiro, Tomoyuki Asano, Shuzo Sato, Haruki Matsumoto, Hiroshi Watanabe, Hideko Kozuru, Hiroshi Yatsuhashi, Atsushi Kawakami and Kiyoshi Migita
    Citation: BMC Immunology 2020 21:35
    Content type: Research article Published on:

  17. Members of the United States Armed Forces receive a series of vaccinations during their course of service. To investigate the influence of multiple vaccinations on innate immunity, we measured concentrations o...

    Authors: Beda Brichacek, Christophe Vanpouille, Alexander J Trachtenberg, Tatiana Pushkarsky, Larisa Dubrovsky, Gregory Martin, Gary Simon and Michael Bukrinsky
    Citation: BMC Immunology 2006 7:21
    Content type: Research article Published on:

  18. CD72, a co-receptor of B cell receptor (BCR), has been reported to have both positive and negative effects on B cell functions in several immunological diseases. The B cell plays an important role in the patho...

    Authors: Yuqi Shen, Yuhua Ma, Jingyuan Xie, Li Lin, Yifan Shi, Xiao Li, Pingyan Shen, Xiaoxia Pan and Hong Ren
    Citation: BMC Immunology 2020 21:21
    Content type: Research article Published on:

  20. Leukocyte Ig-like receptors (LILR) are a family of innate immune receptors with immunomodulatory functions. High-level expression of the receptors LILRB2 (ILT4) and LILRB4 (ILT3) is a feature of tolerogenic an...

    Authors: Damien P Brown, Des C Jones, Katie J Anderson, Nicolas Lapaque, Robin A Buerki, John Trowsdale and Rachel L Allen
    Citation: BMC Immunology 2009 10:56
    Content type: Research article Published on:

  21. Cryptococcosis, a fatal fungal infection of the central nervous system, is one of the major killers of AIDS patients and other immunocompromised hosts. The causative agent, Cryptococcus neoformans, has a remarkab...

    Authors: Hansong Ma, Joanne E Croudace, David A Lammas and Robin C May
    Citation: BMC Immunology 2007 8:15
    Content type: Research article Published on:

  22. The T cell antigen receptors (TCR) of αβ and γδ T lymphocytes are believed to assemble in a similar fashion in humans. Firstly, αβ or γδ TCR chains incorporate a CD3δε dimer, then a CD3γε dimer and finally a ζ...

    Authors: Miguel Muñoz-Ruiz, Verónica Pérez-Flores, Beatriz Garcillán, Alberto C Guardo, Marina S Mazariegos, Hidetoshi Takada, Luis M Allende, Sara S Kilic, Ozden Sanal, Chaim M Roifman, Eduardo López-Granados, María J Recio, Eduardo Martínez-Naves, Edgar Fernández-Malavé and José R Regueiro
    Citation: BMC Immunology 2013 14:3
    Content type: Research article Published on:

  23. IFNγ-producing CD4+CD25+Foxp3+ PBL represent a subtype of iTreg that are associated with good long-term graft outcome in renal transplant recipients and suppress alloresponses in-vitro. To study the mechanism of ...

    Authors: Volker Daniel, Mahmoud Sadeghi, Haihao Wang and Gerhard Opelz
    Citation: BMC Immunology 2012 13:47
    Content type: Research article Published on:

  24. Preterm birth (PTB) is one of the major causes of neonatal morbidity and mortality worldwide. It is commonly accepted that the act of giving birth is the final step in a proinflammatory signaling cascade, orch...

    Authors: João Mendes, Paulo Rodrigues-Santos, Ana Luísa Areia, Jani-Sofia Almeida, Vera Alves, Manuel Santos-Rosa and Anabela Mota-Pinto
    Citation: BMC Immunology 2021 22:28
    Content type: Research Published on:

  25. At present, the relatively sudden appearance and explosive spread of HIV throughout Africa and around the world beginning in the 1950s has never been adequately explained. Theorizing that this phenomenon may b...

    Authors: Raymond S Weinstein, Michael M Weinstein, Kenneth Alibek, Michael I Bukrinsky and Beda Brichacek
    Citation: BMC Immunology 2010 11:23
    Content type: Research article Published on:

  26. The application of vaccine adjuvants has been vigorously studied for a diverse range of diseases in order to improve immune responses and reduce toxicity. However, most adjuvants have limited uses in clinical ...

    Authors: Kyung Hee Noh, Yeong Min Park, Hyuk Soon Kim, Tae Heung Kang, Kwon-Ho Song, Young-Ho Lee, Yeongseon Byeon, Hat Nim Jeon, In Duk Jung, Byung Cheol Shin, Kyung-Mi Lee, Seung-Yong Seong, Hee Dong Han and Tae Woo Kim
    Citation: BMC Immunology 2014 15:48
    Content type: Research article Published on:

  28. The concept of the immunogenicity of an antigen is frequently encountered in the context of vaccine development, an area of intense interest currently due to the emergence or re-emergence of infectious pathogens ...

    Authors: Siddhartha Mahanty, Antoine Prigent and Olivier Garraud
    Citation: BMC Immunology 2015 16:31
    Content type: Review Published on:

  29. The use of inbred mice housed under standardized environmental conditions has been critical in identifying immuno-pathological mechanisms in different infectious and inflammatory diseases as well as revealing ...

    Authors: Josue Enriquez, Brianyell Mc Daniel Mims, Scott Trasti, Kathryn L. Furr and Matthew B. Grisham
    Citation: BMC Immunology 2020 21:50
    Content type: Review Published on:

  30. Epstein-Barr virus (EBV) infection immortalizes primary B cells in vitro and generates lymphoblastoid cell lines (LCLs), which are used for several purposes in immunological and genetic studies. Purinergic rec...

    Authors: Dong Hyeon Lee, Kyu Sang Park, In Deok Kong, Jun Woo Kim and Bok Ghee Han
    Citation: BMC Immunology 2006 7:22
    Content type: Research article Published on:

  31. HLA class II tetramers can be used for ex vivo enumeration and phenotypic characterisation of antigen-specific CD4+ T cells. They are increasingly applied in settings like allergy, vaccination and autoimmune d...

    Authors: Christina Gerstner, Sara Turcinov, Aase H. Hensvold, Karine Chemin, Hannes Uchtenhagen, Tamara H. Ramwadhdoebe, Anatoly Dubnovitsky, Genadiy Kozhukh, Lars Rönnblom, William W. Kwok, Adnane Achour, Anca I. Catrina, Lisa G. M. van Baarsen and Vivianne Malmström
    Citation: BMC Immunology 2020 21:27
    Content type: Research article Published on:

  32. Common variable immunodeficiency (CVID) comprises a heterogeneous group of primary antibody deficiencies with complex clinical and immunological phenotypes. The recent discovery that some CVID patients show mo...

    Authors: Ulrich Salzer, Carla Neumann, Jens Thiel, Cristina Woellner, Qiang Pan-Hammarström, Vassilis Lougaris, Tina Hagena, Johannes Jung, Jennifer Birmelin, Likun Du, Ayse Metin, David A Webster, Alessandro Plebani, Viviana Moschese, Lennart Hammarström, Alejandro A Schäffer…
    Citation: BMC Immunology 2008 9:3
    Content type: Research article Published on:

  34. Host genetics influence the outcome of HCV disease. HCV is also highly mutable and escapes host immunity. HCV genotypes are geographically distributed and HCV subtypes have been shown to have distinct repertoi...

    Authors: Nishi Prabdial-Sing, Adrian J Puren and Sheila M Bowyer
    Citation: BMC Immunology 2012 13:67
    Content type: Research article Published on:

  36. We have shown previously that acute infection with the respiratory pathogen, pneumonia virus of mice (PVM), results in local production of the proinflammatory chemokine, CCL3, and that neutrophil recruitment i...

    Authors: Cynthia A Bonville, Caroline M Percopo, Kimberly D Dyer, Jiliang Gao, Calman Prussin, Barbara Foster, Helene F Rosenberg and Joseph B Domachowske
    Citation: BMC Immunology 2009 10:14
    Content type: Research article Published on:

  37. As a member of the TNF superfamily, TRAIL could induce human tumor cell apoptosis through its cognate death receptors DR4 or DR5, which can induce formation of the death inducing signaling complex (DISC) and a...

    Authors: Chunxia Qiao, Meiyun Hu, Leiming Guo, Ming Lv, Zhou Lin, Jing Geng, Xiaoling Lang, Xinying Li, Yan Li, Yuanfang Ma, Jiannan Feng and Beifen Shen
    Citation: BMC Immunology 2012 13:40
    Content type: Research article Published on:

  38. Deer mice (Peromyscus maniculatus) are the principal reservoir hosts of Sin Nombre virus (SNV), the cause of the great majority of hantavirus cardiopulmonary syndrome (HCPS) cases in North America. SNV, like all ...

    Authors: Tony Schountz, Timothy I Shaw, Travis C Glenn, Heinz Feldmann and Joseph Prescott
    Citation: BMC Immunology 2013 14:18
    Content type: Methodology article Published on:

  39. The use of anti-B cell based therapies in immune-mediated diseases targeting general B cell markers or molecules important for B cell function has increased the clinical needs of monitoring B cell subpopulations.

    Authors: Susanne Axelsson, Anders Magnuson, Anna Lange, Aseel Alshamari, Elisabeth Hultgren Hörnquist and Olof Hultgren
    Citation: BMC Immunology 2020 21:14
    Content type: Research article Published on:

  40. Epithelial cells and dendritic cells (DCs) both initiate and contribute to innate immune responses to bacteria. However, much less is known about the coordinated regulation of innate immune responses between G...

    Authors: Lei Yin, Takahiro Chino, Orapin V Horst, Beth M Hacker, Edward A Clark, Beverly A Dale and Whasun O Chung
    Citation: BMC Immunology 2010 11:37
    Content type: Research article Published on:

  41. Continuous attempts have been made to pinpoint candidate vaccine molecules and evaluate their effectiveness in order to commercialise such vaccines for the treatment of tropical fascioliasis in livestock. The ...

    Authors: Kanhu Charan Das, Ruchishree Konhar and Devendra Kumar Biswal
    Citation: BMC Immunology 2023 24:1
    Content type: Research Published on:

  42. Transforming growth factor (TGF)-β is a potent immunosuppressive cytokine necessary for cancer growth. Animal and human studies have shown that pharmacologic inhibition of TGF-β slows the growth rate of establ...

    Authors: Jon G Quatromoni, Eiji Suzuki, Olugbenga Okusanya, Brendan F Judy, Pratik Bhojnagarwala, Ollin Venegas, Evgeniy Eruslanov, Jarrod D Predina, Steven M Albelda and Sunil Singhal
    Citation: BMC Immunology 2013 14:30
    Content type: Research article Published on:

  43. Cysteinyl leukotrienes are potent inflammatory mediators implicated in the pathogenesis of asthma. Human cysteinyl leukotriene receptor 1 (CYSLTR1) gene contains five exons that are variably spliced. Within its p...

    Authors: Milena Sokolowska, Karolina Wodz-Naskiewicz, Malgorzata Cieslak, Karolina Seta, Andrzej K Bednarek and Rafal Pawliczak
    Citation: BMC Immunology 2009 10:63
    Content type: Research article Published on:

  44. Mendelian Susceptibility to Mycobacterial Disease (MSMD) is a primary immunodeficiency (PID) characterised by a predisposition to infection by weakly-pathogenic mycobacteria. In countries with a high prevalenc...

    Authors: Ansia van Coller, Brigitte Glanzmann, Helena Cornelissen, Marlo Möller, Craig Kinnear, Monika Esser and Richard Glashoff
    Citation: BMC Immunology 2021 22:62
    Content type: Research Published on:

  45. In former studies we showed in a rat model of renal transplantation that Mesenchymal Stromal Cells (MSC) prevent acute rejection in an independent way of their endowing in the graft. In this study we investiga...

    Authors: Marilena Gregorini, Francesca Bosio, Chiara Rocca, Valeria Corradetti, Teresa Valsania, Eleonora Francesca Pattonieri, Pasquale Esposito, Giulia Bedino, Chiara Collesi, Carmelo Libetta, Francesco Frassoni, Antonio Dal Canton and Teresa Rampino
    Citation: BMC Immunology 2014 15:44
    Content type: Research article Published on:

  46. Exposure to Staphylococcal Enterotoxin B (SEB), a bacterial superantigen secreted by the Gram-positive bacteria Staphyloccocus aureus, results in the expansion and eventual clonal deletion and anergy of Vβ8+ T ce...

    Authors: Melanie J Ragin, Jianfang Hu, Andrew J Henderson and Avery August
    Citation: BMC Immunology 2005 6:19
    Content type: Research article Published on:

  47. Cancer cells subvert natural immunosuppression by upregulating the expression of checkpoint proteins and their ligands. For example, tumor cells expressing programmed death-ligand 1 (PD-L1) induce immune cell ...

    Authors: Isabella McGoverne, Jenny Dunn, Jacob Batham, Wen Juan Tu, Jeremy Chrisp and Sudha Rao
    Citation: BMC Immunology 2020 21:22
    Content type: Review Published on:

  48. Previous studies have shown that tuberculosis (TB) is a risk factor for chronic airflow limitation. Chronic obstructive pulmonary disease (COPD) is recognized as the result of chronic inflammation, usually rel...

    Authors: Elise Guiedem, Eric Walter Pefura-Yone, George Mondinde Ikomey, Céline Nguefeu Nkenfou, Martha Mesembe, Mbanyamsig Mispa Yivala, Bih Hycenta Chendi, Graeme Brendon Jacobs, Novel Njweipi Chegou and Marie Claire Assoumou Okomo
    Citation: BMC Immunology 2020 21:52
    Content type: Research article Published on:

  49. Behcet’s disease (BD) is a relapsing systemic vascular autoimmune/inflammatory disease. Despite much effort to investigate BD, there are virtually no unique laboratory markers identified to help in the diagnos...

    Authors: Linlin Cheng, Yang Li, Ziyan Wu, Liubing Li, Chenxi Liu, Jianhua Liu, Jiayu Dai, Wenjie Zheng, Fengchun Zhang, Liujun Tang, Xiaobo Yu and Yongzhe Li
    Citation: BMC Immunology 2021 22:16
    Content type: Research article Published on:

  50. In addition to its role in antigen presentation, recent reports establish a new role for endoplasmic reticulum aminopeptidase 1 (ERAP1) in innate immunity; however, the mechanisms underlying these functions ar...

    Authors: Maja K. Blake, Patrick O’Connell, Yuliya Pepelyayeva, Sarah Godbehere, Yasser A. Aldhamen and Andrea Amalfitano
    Citation: BMC Immunology 2022 23:9
    Content type: Research Published on:

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