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Articles

1080 result(s) for 'immunology' within BMC Immunology

Page 20 of 22

  1. Although histone methyltransferases EZH2 has been proved to have significant regulatory effect on the immune rejection after hematopoietic stem cell transplantation, its role in solid-organ transplantation rem...

    Authors: Long Li, Yi Zhang, Ming Xu, Ruiming Rong, Jina Wang and Tongyu Zhu
    Citation: BMC Immunology 2016 17:41
  2. Type 1 diabetes (T1D) is thought to be an autoimmune disease driven by anti-islet antigen responses and mediated by T-cells. Recent published data suggests that T-cell reactivity to modified peptides, effectiv...

    Authors: John Sidney, Jose Luis Vela, Dave Friedrich, Ravi Kolla, Matthias von Herrath, Johnna D. Wesley and Alessandro Sette
    Citation: BMC Immunology 2018 19:12
  3. Mast cells are hematopoietically derived cells that play a role in inflammatory processes such as allergy, as well as in the immune response against pathogens by the selective and rapid release of preformed an...

    Authors: Valéria Cintra Barbosa-Lorenzi, Nerry Tatiana Cecilio, Patricia Andressa de Almeida Buranello, Maria Cristina Pranchevicius, Maria Helena S. Goldman, Gabriela Pereira-da-Silva, Maria Cristina Roque-Barreira, Maria Célia Jamur and Constance Oliver
    Citation: BMC Immunology 2016 17:22
  4. Tristetraprolin (TTP) is an RNA binding protein that plays a critical role in regulating proinflammatory immune responses by destabilizing target mRNAs via binding to their AU-rich elements (AREs) in the 3′-UT...

    Authors: Yafang Tu, Xiongfei Wu, Fengyun Yu, Jianzhong Dang, Juan Wang, Yaxun Wei, Zhitao Cai, Zhipeng Zhou, Wenliang Liao, Lian Li and Yi Zhang
    Citation: BMC Immunology 2019 20:13
  5. Myeloid derived suppressor cells (MDSCs) present a significant obstacle to cancer immunotherapy because they dampen anti-tumor cytotoxic T cell responses. Previous groups, including our own, have reported on t...

    Authors: Andrea J. Luker, Laura J. Graham, Timothy M. Smith Jr, Carmen Camarena, Matt P. Zellner, Jamie-Jean S. Gilmer, Sheela R. Damle, Daniel H. Conrad, Harry D. Bear and Rebecca K. Martin
    Citation: BMC Immunology 2020 21:8
  6. To investigate the impact of miRNA (microRNA) on hepatic oxidative stress damage under the human mesenchymal stem cell conditioned medium (MSC-CM) and explore the roles of the beta-1 adrenergic receptor (ADRB1...

    Authors: Xuejing Xu, Dong Li, Xue Li, Qing Shi and Xiuli Ju
    Citation: BMC Immunology 2017 18:51
  7. Recently, the immunostimulatory roles of chemotherapeutics have been increasingly revealed, although bone marrow suppression is still a common toxicity of chemotherapy. While the numbers and ratios of differen...

    Authors: Yanhong Wu, Zhenling Deng, Huiru Wang, Wenbo Ma, Chunxia Zhou and Shuren Zhang
    Citation: BMC Immunology 2016 17:29
  8. The spleen is an important site for hematopoiesis. It supports development of myeloid cells from bone marrow-derived precursors entering from blood. Myeloid subsets in spleen are not well characterised althoug...

    Authors: Ying-Ying Hey, Benjamin Quah and Helen C. O’Neill
    Citation: BMC Immunology 2017 18:4
  9. While tumor necrosis factor alpha (TNF-α) inhibitors (TNFi) and other biologics are very effective against autoimmune diseases, they can also cause infectious diseases. Therefore, it is important to clarify wh...

    Authors: Shoichi Fukui, Hideki Nakamura, Yoshiko Takahashi, Naoki Iwamoto, Hiroo Hasegawa, Katsunori Yanagihara, Tatsufumi Nakamura, Akihiko Okayama and Atsushi Kawakami
    Citation: BMC Immunology 2017 18:7
  10. Mannose-binding lectin (MBL) is a key component of innate immunity. Low serum MBL levels, related to promoter polymorphism and structural variants, have been associated with an increased risk of infection. The...

    Authors: M. Puente, C. Fariñas-Alvarez, A. Moreto, P. Sánchez-Velasco, J. G. Ocejo-Vinyals and M. C. Fariñas
    Citation: BMC Immunology 2019 20:40
  11. Inflammatory skin diseases such as atopic dermatitis and psoriasis represent a complex interaction between the skin and infiltrating immune cells, resulting in damage to the skin barrier and increased inflamma...

    Authors: Pauline Muscat, Karessa Mercado, Kathryn Payne, Hardip Chahal and Graham Jones
    Citation: BMC Immunology 2015 16:69
  12. The adaptive immune system maintains a diversity of T cells capable of recognizing a broad array of antigens. Each T cell’s specificity for antigens is determined by its T cell receptors (TCRs), which together...

    Authors: Nathaniel D. Chu, Haixin Sarah Bi, Ryan O. Emerson, Anna M. Sherwood, Michael E. Birnbaum, Harlan S. Robins and Eric J. Alm
    Citation: BMC Immunology 2019 20:19
  13. Polymorphisms in cytokine genes are known to influence cytokine levels, which may influence susceptibility to tuberculosis (TB) infection and disease. Differences in cytokine expression probably determine whet...

    Authors: Yi Hu, Linlin Wu, Dange Li, Qi Zhao, Weili Jiang and Biao Xu
    Citation: BMC Immunology 2015 16:8
  14. Circulating follicular helper T (cTfh) cells are a specialized subset of CD4+ T cells that express the CXC-chemokine receptor 5 (CXCR5). These cells exhibit immune activities by inducing B cell differentiation an...

    Authors: Meng Xu, Yanfang Jiang, Jian Zhang, Yan Zheng, Deying Liu, Lishuang Guo and Sirui Yang
    Citation: BMC Immunology 2018 19:43
  15. Pertussis (whooping cough) remains a public health problem despite extensive vaccination strategies. Better understanding of the host-pathogen interaction and the detailed B. pertussis (Bp) target recognition pat...

    Authors: Davide Valentini, Giovanni Ferrara, Reza Advani, Hans O Hallander and Markus J Maeurer
    Citation: BMC Immunology 2015 16:40
  16. Mycobacterium tuberculosis (M. tuberculosis) modulates host immune response, mainly T cell responses for its own survival leading to disease or latent infection. The molecules and mech...

    Authors: Bhawna Sharma, Rajni Upadhyay, Bhavyata Dua, Naim Akhtar Khan, Vishwa Mohan Katoch, Bharat Bajaj and Beenu Joshi
    Citation: BMC Immunology 2015 16:67
  17. While the 23-valent pneumococcal polysaccharide vaccine (PPV23) is routinely used in Canada and some other countries to prevent pneumococcal infection in adults with chronic kidney disease (CKD), patients deve...

    Authors: Gabrielle Nicole Gaultier, William McCready and Marina Ulanova
    Citation: BMC Immunology 2019 20:41
  18. Non-adherence has been associated with reduced graft survival. The aim of this study was to investigate the immunological mechanisms underlying chronic renal allograft rejection using a model of non-adherence ...

    Authors: Louisa Kühne, Bettina Jung, Helen Poth, Antonia Schuster, Simone Wurm, Petra Ruemmele, Bernhard Banas and Tobias Bergler
    Citation: BMC Immunology 2017 18:52
  19. Non-small cell lung cancer (NSCLC) remains the most common cause of cancer related death worldwide. Tumor-infiltrating macrophages are believed to play an important role in growth, progression, and metastasis ...

    Authors: Jurgita Jackute, Marius Zemaitis, Darius Pranys, Brigita Sitkauskiene, Skaidrius Miliauskas, Simona Vaitkiene and Raimundas Sakalauskas
    Citation: BMC Immunology 2018 19:3
  20. The Major Histocompatibility Complex (MHC) class I family of genes encode for molecules that have well-conserved structures, but have evolved to perform diverse functions. The availability of the gray, short-t...

    Authors: Katina V. Krasnec, Anthony T. Papenfuss and Robert D. Miller
    Citation: BMC Immunology 2016 17:43
  21. The small intestine is a specialized compartment were close interactions take place between host, microbes, food antigens and dietary fatty acids. Dietary fats get absorbed by epithelial cells and processed in...

    Authors: Jeroen van Bergenhenegouwen, Aletta D. Kraneveld, Lieke Rutten, Johan Garssen, Arjan P. Vos and Anita Hartog
    Citation: BMC Immunology 2016 17:42
  22. Mesenchymal stromal cells (MSCs) are multipotent progenitor cells known to modulate the immune system and to promote hematopoiesis. These dual effects make MSCs attractive for use as cellular therapy in hemato...

    Authors: Elizabeth O. Stenger, Lakshmanan Krishnamurti and Jacques Galipeau
    Citation: BMC Immunology 2015 16:74
  23. Macrophages are key players in the initiation, perpetuation and regulation of both innate and adaptive immune responses. They largely perform these roles through modulation of the expression of genes, especial...

    Authors: Akane Tanaka, Joyce To, Bronwyn O’Brien, Sheila Donnelly and Maria Lund
    Citation: BMC Immunology 2017 18:43
  24. Proinflammatory genes are highly expressed in several metabolic disorders associated with obesity. But it is not clarified whether gene expression levels and downstream inflammatory markers are related to the ...

    Authors: Parichehr Amiri, Behzad Baradaran, Maryam Saghafi-Asl, Mahsa Naghizadeh, Dariush Shanehbandi, Nahid Karamzad and Sepideh Zununi Vahed
    Citation: BMC Immunology 2019 20:23
  25. Cold stress, which may lead to local and systemic injury, is reported to be related to the immune system, especially the complement system. At present, the lack of effective treatment is a critical issue. Amen...

    Authors: Jiayi Cai, Chunyang Zhao, Yajie Du, Yuan Huang and Qingchun Zhao
    Citation: BMC Immunology 2019 20:49
  26. High-throughput sequencing of T cell receptor (TCR) genes is a powerful tool for analyses of antigen specificity, clonality and diversity of T lymphocytes. Here, we developed a new TCR repertoire analysis meth...

    Authors: Kazutaka Kitaura, Tadasu Shini, Takaji Matsutani and Ryuji Suzuki
    Citation: BMC Immunology 2016 17:38
  27. Active immunotherapy targeting amyloid-β (Aβ) is a promising treatment for Alzheimer’s disease (AD). Numerous preclinical studies and clinical trials demonstrated that a safe and effective AD vaccine should in...

    Authors: Ping Yang, Yongqing Guo, Yao Sun, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu and Wei Kong
    Citation: BMC Immunology 2019 20:9
  28. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, is induced by immunization of mice with myelin oligodendrocytic glycoprotein (MOG35-55) injections, and after 9 days, mice d...

    Authors: Patricia J McLaughlin, Daniel P McHugh, Marcus J Magister and Ian S Zagon
    Citation: BMC Immunology 2015 16:24
  29. T follicular helper (Tfh) cells play a control role in contribution of B cell differentiation and antibody production. T follicular regulatory (Tfr) cells inhibit Tfh-B cell interaction.

    Authors: Lin Yan, Yamei Li, Yi Li, Xiaojuan Wu, Xianding Wang, Lanlan Wang, Yunying Shi and Jiangtao Tang
    Citation: BMC Immunology 2019 20:26
  30. Gulf War Illness (GWI) is a clinically heterogeneous chronic condition that affects many veterans of the 1990–1991 Persian Gulf War. One of the most prevalent and debilitating symptoms of GWI is abnormal fatig...

    Authors: Luke Parkitny, Stephanie Middleton, Katharine Baker and Jarred Younger
    Citation: BMC Immunology 2015 16:57
  31. High-dose intravenous immunoglobulin (IVIg), and more recently, subcutaneously-delivered Ig (SCIg), are used to treat a variety of autoimmune diseases; however, there are challenges associated with product pro...

    Authors: Bonnie J. B. Lewis, Jade Ville, Megan Blacquiere, Selena Cen, Rolf Spirig, Adrian W. Zuercher, Fabian Käsermann and Donald R. Branch
    Citation: BMC Immunology 2019 20:44
  32. Delayed wound healing reduces the quality of life (QOL) of patients. Thus, understanding the mechanism of wound healing is indispensable for better management. However, the role of innate immunity in wound hea...

    Authors: Kazuhide Takada, Shihoko Komine-Aizawa, Naoko Hirohata, Quang Duy Trinh, Atsuyoshi Nishina, Hirokazu Kimura and Satoshi Hayakawa
    Citation: BMC Immunology 2017 18:19
  33. Pentraxins are a family of highly conserved secreted proteins that regulate the innate immune system, including monocytes and macrophages. C-reactive protein (CRP) is a plasma protein whose levels can rise to ...

    Authors: Wensheng Chen, Darrell Pilling and Richard H. Gomer
    Citation: BMC Immunology 2017 18:47
  34. The lung is exposed to airborne fungal spores, and fungi that colonize the oral cavity such as Candida albicans, but does not develop disease to opportunistic fungal pathogens unless the immune system is compromi...

    Authors: Sabarirajan Jayaraja, Azzeddine Dakhama, Bogeon Yun, Moumita Ghosh, HeeJung Lee, Elizabeth F. Redente, Charis L. Uhlson, Robert C. Murphy and Christina C. Leslie
    Citation: BMC Immunology 2016 17:27
  35. We sought to compare Pneumovax®23 responses in adults with subnormal IgG subclass concentrations. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or Ig...

    Authors: Antony R. Parker, Markus Skold, Stephen Harding, J. Clayborn Barton, Luigi F. Bertoli and James C. Barton
    Citation: BMC Immunology 2019 20:29
  36. Technical feasibility of RNA quantification by real time RT-PCR has led to enormous utilization of this method. However, real time PCR results need to be normalized due to the high sensitivity of the method an...

    Authors: Mehdi Emam, Kathleen Thompson-Crispi and Bonnie Mallard
    Citation: BMC Immunology 2015 16:33
  37. The potency of T regulatory (TREG) cells to inhibit T helper (Th)-driven immune cell responses has been linked to increased intracellular cyclic-AMP (cAMP) levels of TREG cells. In an ovalbumin (OVA)-driven al...

    Authors: Kari J. Dugger, Taylor Chrisman, Sarah L. Sayner, Parker Chastain, Kacie Watson and Robert Estes
    Citation: BMC Immunology 2018 19:9
  38. Oxidative damage present in obese/overweight mothers may lead to further oxidative stress conditions or inflammation in maternal and cord blood samples. Thirty-four pregnant women/newborn pairs were included i...

    Authors: María Hernández-Trejo, Araceli Montoya-Estrada, Yessica Torres-Ramos, Aurora Espejel-Núñez, Alberto Guzmán-Grenfell, Rosa Morales-Hernández, Maricruz Tolentino-Dolores and Estibalitz Laresgoiti-Servitje
    Citation: BMC Immunology 2017 18:3
  39. Natural killer cell responses to virally-infected or transformed cells depend on the integration of signals received through inhibitory and activating natural killer cell receptors. Human Leukocyte Antigen nul...

    Authors: Alexandra Tremblay-McLean, Sita Coenraads, Zahra Kiani, Franck P. Dupuy and Nicole F. Bernard
    Citation: BMC Immunology 2019 20:8
  40. Mouse models have been extremely valuable in identifying the fundamental mechanisms of airway inflammation that underlie human allergic asthma. Several models are commonly used, employing different methods and...

    Authors: Evelyn J. Hyde, Kirsty A. Wakelin, Naomi J. Daniels, Sayani Ghosh and Franca Ronchese
    Citation: BMC Immunology 2019 20:18
  41. Requisites for an efficacious tuberculosis (TB) vaccine are a minimal genomic diversity among infectious Mycobacterium tuberculosis strains for the selected antigen, and the capability to induce robust T-cell res...

    Authors: Marie-Cécile Mortier, Erik Jongert, Pascal Mettens and Jean-Louis Ruelle
    Citation: BMC Immunology 2015 16:63
  42. There is now good evidence that cytokines and growth factors are key factors in tissue repair and often exert anti-infective activities. However, engineering such factors for global use, even in the most remot...

    Authors: Olivier Garraud, Wael N. Hozzein and Gamal Badr
    Citation: BMC Immunology 2017 18(Suppl 1):23

    This article is part of a Supplement: Volume 18 Supplement 1

  43. Bacterial genomes span a significant portion of diversity, reflecting their adaptation strategies; these strategies include nucleotide usage biases that affect chromosome configuration. Here, we explore an imm...

    Authors: Shireen Nigar, Yoshinari Yamamoto, Takuma Okajima, Suguru Shigemori, Takashi Sato, Tasuku Ogita and Takeshi Shimosato
    Citation: BMC Immunology 2017 18:44
  44. Abnormal immune function is often an underlying component of illness pathophysiology and symptom presentation. Functional and phenotypic immune-related alterations may play a role in the obscure pathomechanism...

    Authors: Sharni Lee Hardcastle, Ekua Weba Brenu, Samantha Johnston, Thao Nguyen, Teilah Huth, Naomi Wong, Sandra Ramos, Donald Staines and Sonya Marshall-Gradisnik
    Citation: BMC Immunology 2015 16:35
  45. Chronic eosinophilic pneumonia (CEP) or eosinophilic gastroenteritis (EG), or both, with asthma precede the onset of eosinophilic granulomatosis with polyangiitis (EGPA) in half of all EGPA patients. It is not...

    Authors: Naomi Tsurikisawa, Chiyako Oshikata, Takahiro Tsuburai, Satoshi Sugano, Yoko Nakamura, Takuya Shimoda, Shunpei Tamama, Ken Adachi, Ayako Horita, Ikuo Saito and Hiroshi Saito
    Citation: BMC Immunology 2015 16:75
  46. Monocytes and macrophages produce interleukin (IL)-10, an immunoregulatory cytokine and a potent therapeutic tool for immune disorders. Augmentation of IL-10 production with a concomitant reduction of proinfla...

    Authors: Masanori Inui, Kino Tazawa, Yoshiro Kishi and Toshiyuki Takai
    Citation: BMC Immunology 2015 16:20

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