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Table 1 Effect of SCH 546738 on CXCR3 from various species

From: A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection

Species

Human

Monkey

Dog

Mouse

Rat

IC50 (nM)

(CXCL10)

0.8

1.3

6.4

5.9

4.2

  1. Competition binding assays using [125I]hCXCL10 were carried out as described in Methods with membranes prepared from Ba/F3 cells expressing human, monkey, dog, mouse and rat CXCR3 receptors.
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BMC Immunology

ISSN: 1471-2172

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