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Research article
Cancer therapeutic vaccine induced cytotoxic T cell (CTL) responses are pivotal for the killing of tumour cells. Blocking interleukin 10 (IL-10) signalling at the time of immunization increases vaccine induced...
BMC Immunology 2017 18:40
Published on: 15 August 2017
Research article
CIGB-247, a VSSP-adjuvanted VEGF-based vaccine, was evaluated in a phase I clinical trial in patients with advanced solid tumors (CENTAURO). Vaccination with the maximum dose of antigen showed an excellent saf...
BMC Immunology 2017 18:39
Published on: 26 July 2017
Research article
Interleukin-9 (IL-9) was reported as an active participant in the pathogenesis of allergic asthma. This study aimed to investigate the major source ofIL-9 and its effect on interferon γ (IFN-γ) and immunoglobu...
BMC Immunology 2017 18:38
Published on: 19 July 2017
Research article
Epidemiological evidence and animal models suggest that exposure to low and non-neurotoxic concentrations of mercury may contribute to idiosyncratic autoimmune disease. Since defects in function and signaling ...
BMC Immunology 2017 18:37
Published on: 17 July 2017
Research article
Previous studies have shown that γδ TFH cells are capable of modulating antibody production in immunized and infected mouse model. In recent studies, human γδ TFH cells are shown to contribute to the activatio...
BMC Immunology 2017 18:36
Published on: 7 July 2017
Methodology article
IMGT®, the international ImMunoGeneTics information system® (http://www.imgt.org), was created in 1989 in Montpellier, France (CNRS and Montpellier Uni...
BMC Immunology 2017 18:35
Published on: 26 June 2017
Research article
The ability of anti-cytokine antibodies to play a disease-causing role in the pathogenesis of immunodeficiencies is widely accepted. The aim of this study was to investigate whether autoantibodies against BAFF...
BMC Immunology 2017 18:34
Published on: 26 June 2017
Research article
Non-alcoholic fatty liver disease (NAFLD) is a common, chronic liver disease worldwide. Recent studies have shown that T helper (Th) 17 and regulatory T (Treg) cells play critical roles in various disorders of...
BMC Immunology 2017 18:33
Published on: 24 June 2017
Research article
The monoclonal gammopathies are a group of plasma-cell proliferative disorders characterized by the secretion of monoclonal immunoglobulin (M protein or paraprotein). Some rare cases have revealed the specific...
BMC Immunology 2017 18:32
Published on: 23 June 2017
Research
In this work, we develop a theoretical model of an auto immune response. This is based on modifications of standard second messenger trigger models using both signalling pathways and diffusion and a macro leve...
BMC Immunology 2017 18(Suppl 1):24
Published on: 21 June 2017
This article is part of a Supplement: Volume 18 Supplement 1
Research
Moving from the molecular and cellular level to a multi-scale systems understanding of immune responses requires the development of novel approaches to integrate knowledge and data from different biological le...
BMC Immunology 2017 18(Suppl 1):29
Published on: 21 June 2017
This article is part of a Supplement: Volume 18 Supplement 1
Review
There is now good evidence that cytokines and growth factors are key factors in tissue repair and often exert anti-infective activities. However, engineering such factors for global use, even in the most remot...
BMC Immunology 2017 18(Suppl 1):23
Published on: 21 June 2017
This article is part of a Supplement: Volume 18 Supplement 1
Research
The RATE tool was recently developed to computationally infer the HLA restriction of given epitopes from immune response data of HLA typed subjects without additional cumbersome experimentation.
BMC Immunology 2017 18(Suppl 1):20
Published on: 21 June 2017
This article is part of a Supplement: Volume 18 Supplement 1
Research
In this work, we develop a theoretical model that explains the survival data in West Nile Virus infection.
BMC Immunology 2017 18(Suppl 1):22
Published on: 21 June 2017
This article is part of a Supplement: Volume 18 Supplement 1
Methodology article
Recent fundamental and clinical studies have confirmed the effectiveness of utilizing the potential of the immune system to remove tumor cells disseminated in a patient’s body. Cytotoxic T lymphocytes (CTLs) a...
BMC Immunology 2017 18:31
Published on: 20 June 2017
Research article
Circulating bone marrow-derived monocytes can leave the blood, enter a tissue, and differentiate into M1 inflammatory, M2a remodeling/fibrotic, or M2c/Mreg resolving/immune-regulatory macrophages. Macrophages ...
BMC Immunology 2017 18:30
Published on: 15 June 2017
Research article
Humanized mice (hu mice) are based on the transplantation of hematopoietic stem and progenitor cells into immunodeficient mice and have become important pre-clinical models for biomedical research. However, da...
BMC Immunology 2017 18:28
Published on: 30 May 2017
Research article
We have previously reported that interleukin-10 (IL-10) deficient dendritic cells (DCs) are potent antigen presenting cells that induced elevated protective immunity against Chlamydia. To further investigate the ...
BMC Immunology 2017 18:27
Published on: 19 May 2017
Research article
T-helper cell type 1 (Th1) polarization in chronic immune thrombocytopenia (cITP) has been reported at the protein and mRNA levels. We evaluated the impact of Th1/Th2 cytokine and cytokine receptor functional ...
BMC Immunology 2017 18:26
Published on: 16 May 2017
Research article
Porcine circovirus 2 (PCV2) is a small, non-enveloped DNA virus causing swine lymphocyte depletion and severe impact on the swine industry. The aim of this study was to evaluate the antigenicity and immunogeni...
BMC Immunology 2017 18:25
Published on: 15 May 2017
Research article
Activation of inflammasome contributes to the clearance of intracellular bacteria. C-terminus of E. coli EscI protein can activate NLRC4 (NLR family, CARD domain containing-4) inflammasome in macrophages. The pur...
BMC Immunology 2017 18:21
Published on: 3 May 2017
Research article
Delayed wound healing reduces the quality of life (QOL) of patients. Thus, understanding the mechanism of wound healing is indispensable for better management. However, the role of innate immunity in wound hea...
BMC Immunology 2017 18:19
Published on: 24 April 2017
Research article
Type 1 diabetes is an autoimmune disease caused by T cell-mediated destruction of the insulin-producing β-cells in the pancreas. Therefore, approaches that effectively halt the pathogenic T cell response are p...
BMC Immunology 2017 18:18
Published on: 29 March 2017
Research article
To assess the impact of disease activity on health-related quality of life (HRQoL) in systemic lupus erythematosus (SLE).
BMC Immunology 2017 18:17
Published on: 28 March 2017
Research article
Regulatory T (Treg) cells play important roles in autoimmune diseases, cancer, and organ transplantation. Forkhead box protein o1 (Foxo1) and IL-7Rα(CD127) are closely related to the homeostasis of Treg cells....
BMC Immunology 2017 18:16
Published on: 10 March 2017
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