Figure 4

Immunohistochemical staining of 5-LO in MCL and FL biopsies. B cells in the mantle zone from reactive tonsils and mantle cell lymphoma express 5-LO. A) reactive lymph node, right part displays the mantle zone and the left part the germinal centre; B) mantle cell lymphoma; C) follicular lymphoma; D) negative control without primary antibody; E) nuclear staining of 5-LO in neutrophils from a normal tonsil; F) T-cells (CD3⁺) around the mantle zone are 5-LO negative, (figure G is stained with human anti-CD3 antibody). Pictures were taken with a 40×/0.85 numerical aperture (NA) and a 100×/1.30 NA objective lens. GC – germinal centre; MZ – mantle zone. The figure is a representative picture of the investigated samples listed in table 1.