Figure 1

Effect of TM-N49 on rat dermal microvascular leakage. Various doses of TM-N49 were injected into the skin of rat for 20 min. Also shown are the responses to BSA, bradykinin and histamine alone at a dose of 5 μg and normal saline control. Skin reaction represented the area of Evan's blue extravasation. Data are displayed as a boxplot, which indicates the median, interquartile range, the largest and smallest values other than outliers (O) (defined as those which are more than 1.5 box lengths from the median) for 6 animals in each group. * P < 0.05 compared with the response to the diluent only control animals.