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Figure 2 | BMC Immunology

Figure 2

From: Increased levels of soluble CD226 in sera accompanied by decreased membrane CD226 expression on peripheral blood mononuclear cells from cancer patients

Figure 2

Effect of CD226-Fc fusion protein on cytotoxicity of normal PBMC against K562 cells. (A) Expression of CD155 and CD112 by K562 cells. Solid line, CD155 and CD112 staining; black areas, isotype controls. (B) Inhibitory effect of CD226-Fc fusion protein (1000 ng/mL) on cytotoxicity of NK cells against K562 cells. Medium/human Ig (1000 ng/mL) and anti-CD155/CD112 mAbs were used as negative and positive control, respectively. (C) Inhibition of CD226-Fc on cytotoxicity of NK cells against K562 cells in a dose-dependent manner (*, P < 0.05 vs. human Ig of corresponding concentration). The data were the mean ± SD of four wells for each group. Representative experiments are shown (n = 3).

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BMC Immunology

ISSN: 1471-2172

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