Ethanol modulates production of some cytokines in serum, even when administered 24 hr before LPS. Mice were treated with ethanol (6 g/kg by gavage) at the indicated times before LPS, and blood and peritoneal fluid samples were obtained for analysis 2 hr after LPS. Values shown are means ± SEM (n = 5). Because of overlapping values, showing statistical results on the graphs is not practical. Major statistically significant outcomes are identified in the text of the results section.