Table 3 Genetic association between FOXP3 markers and SLE.
Patients | Controls | ||||
|---|---|---|---|---|---|
rs 12843496 allele | Number of alleles (%) | Number of alleles (%) | χ2 | P | OR (95%CI) |
G | 293 (96.7) | 233 (100) | - | ||
A | 10 (3.3) | 0 (0.0) | 6.137 | 0.013 | - |
Total | 303 (100) | 233 (100) | |||
FOX0 allele | |||||
1 | 7 (2.3) | 4 (1.7) | 0.04 | 0.84 | 1.38 (0.40–4.78) |
4 | 189 (61.6) | 121 (50.2) | 6.63 | 0.01 | 1.59 (1.13–2.24) |
5 | 97 (31.6) | 93 (38.6) | 2.61 | 0.10 | 0.74 (0.52–1.05) |
6 | 11 (3.6) | 19 (7.9) | 4.03 | 0.04 | 0.24 (0.11–0.52) |
Rare | 3 (0.9) | 4 (1.6) | 0.10 | 0.75 | 0.81 (0.18–3.63) |
Total | 307 (100) | 241 (100) | 10.3 | 0.036 | |
FOX5 allele | |||||
3 | 188 (63.7) | 137 (57.9) | 1.65 | 0.20 | 1.28 (0.90–1.82) |
8 | 6 (2.0) | 6 (2.6) | 0.01 | 0.92 | 0.80 (0.25–2.49) |
10 | 13 (4.4) | 4 (1.7) | 2.27 | 0.13 | 2.66 (0.86–8.28) |
12 | 17 (5.8) | 21 (8.9) | 1.53 | 0.22 | 0.99 (0.54–1.80) |
13 | 7 (2.4) | 7 (3.0) | 0.03 | 0.87 | 0.79 (0.27–2.29) |
14 | 46 (15.6) | 38 (16.2) | <0.01 | 0.95 | 0.96 (0.60–1.53) |
15 | 3 (1.0) | 5 (2.1) | 0.43 | 0.51 | 0.47 (0.11–2.00) |
16 | 7 (2.4) | 9 (3.8) | 0.52 | 0.47 | 0.61 (0.22–1.66) |
18 | 0 (0.0) | 5 (2.1) | 4.26 | 0.04 | - |
Rare | 8 (2.7) | 4 (1.7) | 0.23 | 0.63 | 1.61 (0.48–5.41) |
Total | 295 (100) | 235 (100) | 14.77 | 0.10 | |
rs 12843496 genotypes | |||||
GG | 136 (93.8) | 77 (100) | 3.51 | 0.06 | - |
GA | 8 (5.5) | 0 (0.0) | 2.96 | 0.09 | - |
AA | 1 (0.7) | 0 (0.0) | 0.11 | 0.74 | - |
Total | 145 (100) | 77 (100) | 4.98 | 0.08 | |
FOX0 genotypes | |||||
4/4 | 50 (33.8) | 22 (25.3) | 1.48 | 0.22 | 1.50 (0.83–2.72) |
4/5 | 63 (42.6) | 35 (40.2) | 0.05 | 0.83 | 1.10 (0.64–1.88) |
4/6 | 9 (6.1) | 6 (6.9) | <0.01 | 0.98 | 0.87 (0.30–2.55) |
5/5 | 12 (8.1) | 13 (14.9) | 2.02 | 0.16 | 0.50 (0.21–1.16) |
Rare | 14 (9.4) | 11 (12.7) | 0.30 | 0.50 | 0.72 (0.31–1.67) |
Total | 148 (100) | 87 (100) | 4.35 | 0.36 | |
FOX5 genotypes | |||||
3/3 | 59 (33.8) | 28 (33.3) | 0.72 | 0.40 | 1.33 (0.76–2.32) |
3/12 | 8 (5.4) | 5 (6.0) | 0.02 | 0.90 | 0.90 (0.29–2.85) |
3/13 | 6 (4.1) | 4 (4.8) | 0.01 | 0.94 | 0.85 (0.23–3.08) |
3/14 | 32 (21.6) | 16 (19.1) | 0.09 | 0.77 | 1.17 (0.60–2.29) |
3/15 | 2 (1.4) | 3 (3.6) | 0.38 | 0.54 | 0.38 (0.06–2.32) |
3/16 | 5 (3.4) | 3 (3.6) | 0.09 | 0.77 | 0.94 (0.22–4.05) |
3/18 | 0 (0.0) | 5 (6.0) | 6.4 | 0.01 | - |
14/14 | 4 (2.7) | 3 (3.6) | <0.01 | 0.98 | 0.75 (0.16–3.43) |
Rare | 32 (21.6) | 17 (20.2) | 0.01 | 0.94 | 1.09 (0.56–2.10) |
Total | 148 (100) | 84 (100) | 11.1 | 0.10 |