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Table 3 Differentially expressed genes in colon tissue of Il10-/-mice compared to C57 mice, and in Il10-/-mice orally inoculated with intestinal bacteria, in common with those observed in human studies

From: Changes in colon gene expression associated with increased colon inflammation in interleukin-10 gene-deficient mice inoculated with Enterococcus species

Gene

RefSeq ID

Mouse Model

  

Transfer

Between strain comparisons (Il10 -/- vs. C57)

Within strain comparisons (Il10 -/- )

   

SPF

C

EF

CIF

EF·CIF

EF vs C

CIF vs C

EF·CIF vs C

Cytokine and cytokineR genes:

Tnf

NM_013693

2.3

1.1

1.1

2.4 c

2.0 c

2.3 c

1.9 c

1.7 b

2.0 c

Ifng

NM_008337

4.7

1.2

1.2

3.2 c

2.1 c

2.4 c

2.3 c

1.9 b

2.0 c

Ltb

NM_008518

8.9

2.0

1.4

3.1 c

2.5 c

2.8 c

2.1 b

2.0 b

2.3 b

Il6

NM_031168

2.6

-1.0

1.0

1.2

1.1

1.2

1.3

1.3

1.4

Il16

NM_010551

2.7

1.1

1.1

1.4 a

1. 1

1.2

1.3

1.2

1.2

Il18R1

NM_008365

17.7

1.2

1.2

1.5 b

1.6 b

1.2

1.3 a

1.3

1.2

Il22

NM_016971

9.3

ND

ND

ND

ND

ND

ND

ND

ND

Chemokine and chemokineR genes:

Ccr2

NM_009915

7.1

1.6 a

1.6 a

2.6 c

2.7 c

1.9 c

1.8 c

1.8 b

1.7 b

Ccr7

NM_007719

2.2

1.0

1.0

-1.2

1.3

1.2

-1.1

1.3

1.1

Ccl2

NM_011333

2.5

1.6

1.4

4.5 c

3.6 c

3.6 c

3.1 c

2.5 c

2.8 c

Ccl3

NM_011337

4.1

-1.0

1.2

1.6

1.6

2.4 a

1.3

1.2

1.9 a

Ccl4

NM_013652

4.3

1.2

1.1

1.9 b

1.7 a

2.2 b

1.8 a

1.7

2.0 b

Ccl5

NM_013653

6.1

1.7

1.0

5.1 c

1.7 a

2.1 b

3.0 c

3.0 c

3.5 c

Ccl7

NM_013654

3.1

1.2

1.1

1.8 b

1.5 a

1.6 c

1.7 b

1.5

1.7 b

Ccl11

NM_011330

1.4

1.1

-1.1

-1.0

1.0

1.1

1.1

1.1

1.3 a

Ccl17

NM_011332

2.4

1.1

1.1

1.3 a

1.4 a

1.1

1.2

1.1

1.0

Ccl20

NM_016960

10.4

1.1

1.0

1.2

1.4 a

1.2

1.1

1.3

1.2

Cxcr3

NM_009910

2.0

1.2

-1.0

1.6 b

1.2

1.4 a

1.5 a

1.3

1.5 a

Cxcl1

NM_008176

4.8

1.0

1.1

2.4 c

1.7 b

2.3 c

1.8 b

1.4

1.9 b

Cxcl5

NM_009141

21.9

1.4

1.3

3.4 c

2.5 c

2.8 c

2.2 c

2.1 b

2.4 c

Cxcl10

NM_021274

14.7

1.6

1.6

6.9 c

6.0 c

7.2 c

3.4 b

2.7 a

2.8 a

Genes involved in tissue remodeling:

Mmp3

NM_010809

28

1.3

1.1

3.7 c

3.1 c

4.0 c

2.9 c

2.6 b

3.8 c

Mmp7

NM_010810

5.3

1.4

1.3

2.3 c

2.0 c

2.2 c

1.6 b

1.4

1.6 b

Mmp9

NM_013599

2.0

1.0

1.1

1.3

1.2

1.2

1.1

1.1

1.1

Mmp14

NM_008608

2.7

1.1

1.2

1.5 a

1.3

1.2

1.1

1.2

1.3

Timp1

NM_011593

1.4

1.2

1.0

1.2

1.3

1.3

1.2

1.3

1.3

Regenerating islet derived genes:

Reg3g

NM_011260

221.8

5.3 a

9.0 b

3.4 a

8.8 c

5.7 b

-1.7

-1.8

-2.2

Pap (Reg3b)

NM_011036

132.1

8.0 b

4.4 a

1.9

5.2 b

2.4

-1.7

-1.8

-2.2

S-100 family genes:

S-100a8

NM_013650

133.1

1.4

1.2

6.5 c

5.8 c

9.0 c

4.7 c

4.2 c

7.1 c

S-100a9

NM_009114

225.4

1.6

1.7

13.8 c

15.7 c

22.8 c

9.2 c

9.5 c

14.2 c

Multidrug resistance (MDR) genes:

Abcb1a

NM_011076

-8.2

-1.3

-2.5 a

-5.7 c

-3.6 c

-4.5 c

-2.3 b

-1.6

-2.1 b

Genes involved in epithelial metabolism and biosynthesis:

Ptgs2

NM_011198

3.2

1.1

1.1

1.3

1.1

1.4

1.3

1.1

1.4

Total DE genes:

30

4

4

22

21

19

11

18

19

  1. Data represent differentially expressed genes for each comparison in common with the 32 genes shown to be differentially expressed in human IBD, with the "Transfer" column showing data from a CD45RB Transfer Colitis model previously published by te Velde et al [35]. Total RNA from colon tissue was used for microarray hybridization to Agilent Technologies 44 k (G4122-60510) mouse 60 mer oligonucleotide arrays. Data represent mean values from two pools of RNA for each mouse strain, with RNA from either two or three mice in each pool. In the case of significantly differentially expressed genes, the text is shown in italics, and denoted by superscript letters where p < 0.05 is represented by a, p < 0.01 by b, and p < 0.001 by c. The total number of differentially expressed genes in each comparison (maximum 32) is shown at the bottom of the table.
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BMC Immunology

ISSN: 1471-2172

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