Table 4 Key functions associated with inflammation in Il10-/- mice identified using Ingenuity Pathways Analysis
Top Function | Number of differentially expressed genes (P-value) | ||||
|---|---|---|---|---|---|
|  | SPF | C | EF | CIF | EF·CIF |
Diseases and Disorders | |||||
Immunological Disease | 9 (< 0.05) | 9 (< 0.05) | 176 (< 0.0001) | 127 (< 0.0005) | 117 (< 0.0005) |
Inflammatory Disease | 7 (< 0.05) | 9 (< 0.05) | 180 (< 0.0001) | 112 (< 0.0005) | 113 (< 0.0005) |
Cancer | 6 (< 0.05) | 9 (< 0.05) | 339 (< 0.0001) | 249 (< 0.0005) | 242 (< 0.0005) |
Organismal injury and abnormality | 7 (< 0.05) | 11 (< 0.05) | 95 (< 0.0001) | 61 (< 0.0005) | 63 (< 0.0005) |
Haematological Disease | 3 (< 0.05) | 4 (< 0.05) | 139 (< 0.0001) | 58 (< 0.0005) | 107 (< 0.0005) |
Molecular and Cellular Function | |||||
Cell-to-cell Signaling and Interaction | 14 (< 0.05) | 11 (< 0.05) | 188 (< 0.0001) | 156 (< 0.0005) | 155 (< 0.0005) |
Cellular Movement | 5 (< 0.05) | 3 (< 0.05) | 192 (< 0.0001) | 156 (< 0.0005) | 164 (< 0.0005) |
Amino Acid Metabolism | 2 (< 0.05) | 2 (< 0.05) | N/A | 72 (< 0.0005) | 78 (< 0.0001) |
Carbohydrate Metabolism | 2 (< 0.05) | 9 (< 0.05) | 59 (< 0.0001) | 102 (< 0.0005) | 113 (< 0.0005) |
Cell Death | 7 (< 0.05) | 10 (< 0.05) | 250 (< 0.0001) | 221 (< 0.0005) | 221 (< 0.0005) |
Physiological System Development and Function | |||||
Immune Response | 22 (< 0.05) | 18 (< 0.05) | 190 (< 0.0001) | 190 (< 0.0005) | 186 (< 0.0005) |
Immune and lymphatic system development | 16 (< 0.05) | 16 (< 0.05) | 169 (< 0.0001) | 150 (< 0.0005) | 150 (< 0.0005) |
Hematological system development and function | 15 (< 0.05) | 14 (< 0.05) | 190 (< 0.0001) | 179 (< 0.0005) | 171 (< 0.0005) |
Tissue morphology | 7 (< 0.05) | 6 (< 0.05) | 134 (< 0.0001) | 108 (< 0.0005) | 114 (< 0.0005) |
Tissue development | 9 (< 0.05) | 1 (< 0.005) | 122 (< 0.0001) | 78 (< 0.0005) | 80 (< 0.0005) |