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Table 1 The antitumor preventive effect of the tumor vaccine composed of irradiated tumor cells and CpG ODNs.

From: Tumor vaccine composed of C-class CpG oligodeoxynucleotides and irradiated tumor cells induces long-term antitumor immunity

Group Number of micea Number of survivorsb Proportion of survivors (%) Average survival AM ± SE (days) p-valuec p-valued
Control 22 0 0.0 16.09 ± 1.14   
1 × 90d* 21 8 38.1 60.38 ± 8.21 <0.0001  
2 × 90d* 20 14 75.0 85.30 ± 5.97 <0.0001 0.012
3 × 90d* 21 19 90.5 94.38 ± 3.93 <0.0001 0.003
1 × 60d** 21 6 28.6 51.00 ± 7.86 <0.0001  
2 × 60d** 22 16 72.7 82.82 ± 6.69 <0.0001 0.002
3 × 60d** 18 16 88.9 89.10 ± 5.12 <0.0001 <0.001
1 × 30d*** 22 7 31.8 62.14 ± 7.60 <0.0001  
2 × 30d*** 22 15 68.2 81.00 ± 6.66 <0.0001 0.022
3 × 30d*** 20 20 100.0 100.00 ± 0.00 <0.0001 0.003
  1. The vaccine was composed of 1 × 106 irradiated B16F1 tumor cells and 30 μg of CpG ODNs; each vaccine administration was followed by two additional injections of CpG ODNs (2 and 4 days after vaccine administration).
  2. a number of animals included in the experimental group
  3. b surviving animals - are animals which survived at least 100 days after tumor challenge
  4. c p-value: group compared to control group
  5. d p-value: group compared to group vaccinated once starting the same day prior to tumor challenge
  6. * vaccination started 90 days before the injection of viable tumor cells; the vaccine was applied once (1×), twice (2×) or three times (3×) in 15 days interval
  7. ** vaccination started 60 days before the injection of viable tumor cells; the vaccine was applied once (1×), twice (2×) or three times (3×) in 15 days interval
  8. *** vaccination started 30 days before the injection of viable tumor cells; the vaccine was applied once (1×), twice (2×) in 15 days interval or three times (3×) in 15 days interval, except for the last vaccination, which was performed 7 days after second vaccination
  9. The experiment was repeated three times.