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Table 3 The significantly increased cytotoxicity of bone marrow MNCs obtained from mice pre-vaccinated 90 and 60 days prior to MNCs collection.

From: Tumor vaccine composed of C-class CpG oligodeoxynucleotides and irradiated tumor cells induces long-term antitumor immunity

Group p-valuea p-valueb p-valuec
1 × 90d* 0.014 0.031 0.011
2 × 90d* 0.016 0.023 0.002
3 × 90d* 0.001 0.002 <0.001
1 × 60d** 0.478 0.664 0.245
2 × 60d** 0.007 0.012 <0.001
3 × 60d** 0.001 0.003 <0.001
  1. a p-value: group compared to group vaccinated once 30 days before tumor challenge
  2. b p-value: group compared to group vaccinated twice: 30 and 15 days before tumor challenge
  3. c p-value: group compared to group vaccinated three times: 30, 15 and 7 days before tumor challenge
  4. * vaccination started 90 days before the injection of viable tumor cells; the vaccine was applied once (1×), twice (2×) or three times (3×) in 15 days interval
  5. ** vaccination started 60 days before the injection of viable tumor cells; the vaccine was applied once (1×), twice (2×) or three times (3×) in 15 days interval