SNP
|
Gene
|
Location
|
MAF (%)
|
Median (Q1 - Q3)a
|
Univariate p-value
|
Multi-SNP Results
|
---|
0 Minor Alleles
|
1 Minor Allele
|
2 Minor Alleles
|
Estimateb
|
S.E.c
|
p-value
|
---|
rs2844482
|
LTA
|
5'UTR
|
15.5
|
32(18.6-59.3)
|
41.2(21.3-72.6)
|
72.5(41.5-108.7)
|
0.000
|
0.164
|
0.027
|
<0.001
|
rs1880241
|
IL6
|
5'UTR
|
49.1
|
30.1(17.6-59)
|
36.2(19.8-67.6)
|
40.3(20.3-68.2)
|
0.014
|
0.133
|
0.024
|
<0.001
|
rs2243248
|
IL4
|
5'UTR
|
7.3
|
36.2(19.4-66.2)
|
27.8(16.5-56.2)
|
17.9(17.8-129.9)
|
0.023
|
-0.182
|
0.036
|
<0.001
|
rs1800795
|
IL6
|
5'UTR
|
42.8
|
37.2(19.2-70.1)
|
32.6(19-61.4)
|
39.9(19.4-63.1)
|
0.511
|
-0.102
|
0.025
|
<0.001
|
rs2256965
|
LST1
|
intron
|
42.9
|
36.3(18.8-66.7)
|
33.9(18.6-64.5)
|
32.6(21.2-59.4)
|
0.891
|
0.085
|
0.021
|
<0.001
|
rs4787947
|
IL4R
|
5'UTR
|
8.7
|
32.7(18.4-62.4)
|
43.2(26.4-68.8)
|
79.4(48.5-107)
|
0.002
|
0.119
|
0.029
|
<0.001
|
rs2227284
|
IL4
|
intron
|
31.1
|
31.8(18.9-60.1)
|
37.9(19.6-69.5)
|
38.1(18.3-69.7)
|
0.179
|
0.081
|
0.020
|
<0.001
|
rs1800629
|
TNF
|
5'UTR
|
17.4
|
33.7(19.2-61.7)
|
39.5(19.6-73.5)
|
31.2(21.8-68.2)
|
0.132
|
0.104
|
0.026
|
<0.001
|
rs9610
|
IL10RA
|
3'UTR
|
44.1
|
39.9(21.3-69.7)
|
33.2(18.6-66.3)
|
29.6(18.3-52.4)
|
0.004
|
-0.064
|
0.017
|
<0.001
|
rs2256774
|
IL2RA
|
intron
|
33.8
|
33.6(18.1-59.2)
|
33.1(19.5-64.5)
|
42.8(26.1-78.7)
|
0.016
|
0.064
|
0.017
|
<0.001
|
rs9427092
|
ADAR
|
3'UTR
|
22.7
|
33.3(19-61.1)
|
34.8(19.5-67.5)
|
40.3(22.8-83.2)
|
0.102
|
0.069
|
0.021
|
0.001
|
rs2243300
|
IL4
|
5'UTR
|
8.3
|
33.8(19-63.3)
|
37.7(20.1-63.7)
|
46.7(29.1-262.1)
|
0.252
|
0.100
|
0.032
|
0.002
|
rs1153592
|
RARB
|
intron
|
16.4
|
36.6(19.6-65.4)
|
31.1(18.1-60.1)
|
41.4(20.5-61.1)
|
0.079
|
-0.067
|
0.023
|
0.003
|
rs228979
|
IL2RB
|
intron
|
26.0
|
37.3(20.6-66.5)
|
31.2(18-59.7)
|
25.9(18.8-67.6)
|
0.048
|
-0.053
|
0.019
|
0.005
|
rs3091338
|
IL3
|
3'UTR
|
38.2
|
33.3(18.2-60.6)
|
33.6(19.5-63.1)
|
39.8(20.7-72.3)
|
0.100
|
0.049
|
0.018
|
0.006
|
rs12757998
|
RNASEL
|
3'UTR
|
28.0
|
33.4(18.8-58.9)
|
37(19.6-68.3)
|
35.5(18.7-72.6)
|
0.130
|
0.052
|
0.019
|
0.006
|
rs1732778
|
OAS2
|
3'UTR
|
25.1
|
32.9(19.2-57.4)
|
38.4(19.1-71.7)
|
37.8(19.3-74.8)
|
0.036
|
0.052
|
0.019
|
0.007
|
rs4648212
|
EIF2AK2
|
intron
|
6.5
|
36.7(19.5-65)
|
27.6(16.6-52)
|
22.7(20.5-23.6)
|
0.018
|
-0.087
|
0.033
|
0.008
|
rs2229857
|
ADAR
|
coding
|
27.4
|
31.2(18-63)
|
40.3(20.5-65)
|
39.1(21.5-64.5)
|
0.072
|
0.049
|
0.019
|
0.011
|
rs17882988
|
TNFRSF1B
|
intron
|
17.3
|
34(18.8-62)
|
33.3(19.7-64.5)
|
67.8(33.2-108.1)
|
0.183
|
0.055
|
0.022
|
0.011
|
rs3740996
|
TRIM5
|
coding
|
10.7
|
37.3(19.6-68.2)
|
27.3(17.6-56.2)
|
39.8(21.1-81.9)
|
0.016
|
-0.069
|
0.027
|
0.011
|
rs2246614
|
MUPCDH
|
coding
|
34.9
|
36.3(20-68.2)
|
32.9(18.9-60.1)
|
35.3(17.7-64.6)
|
0.202
|
-0.043
|
0.018
|
0.014
|
rs2179
|
TRIM22
|
intron
|
30.0
|
37.4(19.6-66.3)
|
33.5(18.2-64.8)
|
26.8(17.2-46.7)
|
0.039
|
-0.044
|
0.018
|
0.015
|
rs2287350
|
EIF2AK2
|
intron
|
38.1
|
33.3(19.5-68.3)
|
36.1(19-67.2)
|
31.1(18.8-53.1)
|
0.057
|
-0.041
|
0.017
|
0.018
|
rs1422876
|
IL12B
|
5'UTR
|
48.9
|
31(17.9-66.2)
|
36.9(19.6-63.7)
|
36.3(19.5-62.2)
|
0.200
|
0.040
|
0.017
|
0.018
|
rs2226299
|
IFNAR1
|
intron
|
18.6
|
33.2(19.2-62.9)
|
35(18.2-67.6)
|
39.1(28.2-60.1)
|
0.308
|
0.049
|
0.021
|
0.022
|
rs6793694
|
RARB
|
intron
|
37.7
|
37.4(19.9-66.5)
|
33.3(18.8-63.1)
|
32.7(17.3-56.8)
|
0.039
|
-0.040
|
0.018
|
0.023
|
rs11064145
|
SCNN1A
|
3'UTR
|
42.5
|
28.4(17.9-61.1)
|
39.7(20.6-67.6)
|
36.5(19.1-60.1)
|
0.100
|
0.038
|
0.017
|
0.024
|
rs12626735
|
TMEM50B
|
3'UTR
|
21.1
|
38.4(19.6-69.7)
|
29.6(18.3-55.8)
|
31.2(18.9-59.1)
|
0.013
|
-0.045
|
0.020
|
0.030
|
- Identified SNPs are all significant when adjusting for all other SNPs shown in the table, and for the descriptive variables outlined in Table 1. Univariate results are shown for comparison.
- Notes:
- a Q1 and Q3 represent the first and third quartiles, the 25th and 75th percentiles, respectively.
- b Estimate represents the difference in log(antibody level) associated with carrying one copy of the minor allele. The anti-log of this quantity provides an estimate of the fold-change in antibody levels associated with carrying one copy of the minor allele.
- c S.E. represents the standard error of the Estimate. The ratio of the Estimate to the S.E. provides a measure of the relative strength of the effect among the SNPs