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Table 2 SNP associations identified through the model selection procedure, sorted from the smallest to the largest multi-SNP p-value.

From: Associations between SNPs in candidate immune-relevant genes and rubella antibody levels: a multigenic assessment

SNP

Gene

Location

MAF (%)

Median (Q1 - Q3)a

Univariate p-value

Multi-SNP Results

0 Minor Alleles

1 Minor Allele

2 Minor Alleles

Estimateb

S.E.c

p-value

rs2844482

LTA

5'UTR

15.5

32(18.6-59.3)

41.2(21.3-72.6)

72.5(41.5-108.7)

0.000

0.164

0.027

<0.001

rs1880241

IL6

5'UTR

49.1

30.1(17.6-59)

36.2(19.8-67.6)

40.3(20.3-68.2)

0.014

0.133

0.024

<0.001

rs2243248

IL4

5'UTR

7.3

36.2(19.4-66.2)

27.8(16.5-56.2)

17.9(17.8-129.9)

0.023

-0.182

0.036

<0.001

rs1800795

IL6

5'UTR

42.8

37.2(19.2-70.1)

32.6(19-61.4)

39.9(19.4-63.1)

0.511

-0.102

0.025

<0.001

rs2256965

LST1

intron

42.9

36.3(18.8-66.7)

33.9(18.6-64.5)

32.6(21.2-59.4)

0.891

0.085

0.021

<0.001

rs4787947

IL4R

5'UTR

8.7

32.7(18.4-62.4)

43.2(26.4-68.8)

79.4(48.5-107)

0.002

0.119

0.029

<0.001

rs2227284

IL4

intron

31.1

31.8(18.9-60.1)

37.9(19.6-69.5)

38.1(18.3-69.7)

0.179

0.081

0.020

<0.001

rs1800629

TNF

5'UTR

17.4

33.7(19.2-61.7)

39.5(19.6-73.5)

31.2(21.8-68.2)

0.132

0.104

0.026

<0.001

rs9610

IL10RA

3'UTR

44.1

39.9(21.3-69.7)

33.2(18.6-66.3)

29.6(18.3-52.4)

0.004

-0.064

0.017

<0.001

rs2256774

IL2RA

intron

33.8

33.6(18.1-59.2)

33.1(19.5-64.5)

42.8(26.1-78.7)

0.016

0.064

0.017

<0.001

rs9427092

ADAR

3'UTR

22.7

33.3(19-61.1)

34.8(19.5-67.5)

40.3(22.8-83.2)

0.102

0.069

0.021

0.001

rs2243300

IL4

5'UTR

8.3

33.8(19-63.3)

37.7(20.1-63.7)

46.7(29.1-262.1)

0.252

0.100

0.032

0.002

rs1153592

RARB

intron

16.4

36.6(19.6-65.4)

31.1(18.1-60.1)

41.4(20.5-61.1)

0.079

-0.067

0.023

0.003

rs228979

IL2RB

intron

26.0

37.3(20.6-66.5)

31.2(18-59.7)

25.9(18.8-67.6)

0.048

-0.053

0.019

0.005

rs3091338

IL3

3'UTR

38.2

33.3(18.2-60.6)

33.6(19.5-63.1)

39.8(20.7-72.3)

0.100

0.049

0.018

0.006

rs12757998

RNASEL

3'UTR

28.0

33.4(18.8-58.9)

37(19.6-68.3)

35.5(18.7-72.6)

0.130

0.052

0.019

0.006

rs1732778

OAS2

3'UTR

25.1

32.9(19.2-57.4)

38.4(19.1-71.7)

37.8(19.3-74.8)

0.036

0.052

0.019

0.007

rs4648212

EIF2AK2

intron

6.5

36.7(19.5-65)

27.6(16.6-52)

22.7(20.5-23.6)

0.018

-0.087

0.033

0.008

rs2229857

ADAR

coding

27.4

31.2(18-63)

40.3(20.5-65)

39.1(21.5-64.5)

0.072

0.049

0.019

0.011

rs17882988

TNFRSF1B

intron

17.3

34(18.8-62)

33.3(19.7-64.5)

67.8(33.2-108.1)

0.183

0.055

0.022

0.011

rs3740996

TRIM5

coding

10.7

37.3(19.6-68.2)

27.3(17.6-56.2)

39.8(21.1-81.9)

0.016

-0.069

0.027

0.011

rs2246614

MUPCDH

coding

34.9

36.3(20-68.2)

32.9(18.9-60.1)

35.3(17.7-64.6)

0.202

-0.043

0.018

0.014

rs2179

TRIM22

intron

30.0

37.4(19.6-66.3)

33.5(18.2-64.8)

26.8(17.2-46.7)

0.039

-0.044

0.018

0.015

rs2287350

EIF2AK2

intron

38.1

33.3(19.5-68.3)

36.1(19-67.2)

31.1(18.8-53.1)

0.057

-0.041

0.017

0.018

rs1422876

IL12B

5'UTR

48.9

31(17.9-66.2)

36.9(19.6-63.7)

36.3(19.5-62.2)

0.200

0.040

0.017

0.018

rs2226299

IFNAR1

intron

18.6

33.2(19.2-62.9)

35(18.2-67.6)

39.1(28.2-60.1)

0.308

0.049

0.021

0.022

rs6793694

RARB

intron

37.7

37.4(19.9-66.5)

33.3(18.8-63.1)

32.7(17.3-56.8)

0.039

-0.040

0.018

0.023

rs11064145

SCNN1A

3'UTR

42.5

28.4(17.9-61.1)

39.7(20.6-67.6)

36.5(19.1-60.1)

0.100

0.038

0.017

0.024

rs12626735

TMEM50B

3'UTR

21.1

38.4(19.6-69.7)

29.6(18.3-55.8)

31.2(18.9-59.1)

0.013

-0.045

0.020

0.030

  1. Identified SNPs are all significant when adjusting for all other SNPs shown in the table, and for the descriptive variables outlined in Table 1. Univariate results are shown for comparison.
  2. Notes:
  3. a Q1 and Q3 represent the first and third quartiles, the 25th and 75th percentiles, respectively.
  4. b Estimate represents the difference in log(antibody level) associated with carrying one copy of the minor allele. The anti-log of this quantity provides an estimate of the fold-change in antibody levels associated with carrying one copy of the minor allele.
  5. c S.E. represents the standard error of the Estimate. The ratio of the Estimate to the S.E. provides a measure of the relative strength of the effect among the SNPs
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BMC Immunology

ISSN: 1471-2172

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