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Table 3 Serum levels (pg/ml) of cytokines, chemokines and adhesion molecules in healthy non-pregnant and pregnant women and preeclamptic patients

From: Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array

 

Healthy non-pregnant women (n = 59)

Healthy pregnant women (n = 60)

Preeclamptic patients (n = 60)

IL-1β

24.5 (23.0-28.0)

27.0 (23.0-31.5)

28.0 (23.0-34.0)

IL-1ra

8.0 (6.7-11.0)

6.0 (5.0-7.0)b

18.0 (11.0-27.5)b,d

IL-2

5.0 (4.2-6.0)

4.0 (4.0-5.0)a

7.5 (5.5-12.0)b,d

IL-4

3.0 (2.0-3.0)

2.0 (2.0-2.0)b

3.0 (3.0-4.0)b,d

IL-6

6.0 (5.0-8.0)

7.0 (5.0-9.0)

15.5 (12.0-32.0)b,d

IL-8

23.0 (18.2-37.5)

24.5 (16.0-68.5)

78.0 (35.0-273)b,d

IL-10

43.7 (32.7-60.5)

15.7 (14.0-19.0)b

23.0 (18.0-35.0)b,d

IL-12p40

119 (109-140)

136 (118-168)a

185 (153-215)b,d

IL-12p70

12.0 (9.0-15.0)

5.0 (4.0-5.0)b

6.0 (5.0-8.0)b,d

IL-18

38.7 (33.0-46.5)

56.0 (44.0-73.7)b

73.5 (55.0-87.0)b,c

IFN-γ

4.0 (3.0-4.0)

3.0 (2.0-3.0)b

5.0 (4.0-6.0)b,d

TNF-α

2.0 (2.0-3.0)

2.0 (1.0-2.0)a

2.0 (2.0-3.0)d

TGF-β1

342 (285-388)

364 (307-413)

383 (331-418)

IP-10

198 (142-327)

327 (222-442)b

688 (434-928)b,d

MCP-1

153 (87.5-233)

79.5 (52.5-110)b

189 (120-283)d

ICAM-1

6638 (6143-7205)

6789 (6201-7672)

8132 (7413-8808)b,d

VCAM-1

6151 (5767-6564)

6157 (5633-6617)

7386 (6913-7709)b,d

  1. Data are presented as median (25-75 percentile)
  2. IL: interleukin; IL-1ra: IL-1 receptor antagonist; IFN: interferon; TNF: tumor necrosis factor; TGF: transforming growth factor; IP: interferon-γ-inducible protein; MCP: monocyte chemotactic protein; ICAM: intercellular adhesion molecule; VCAM: vascular cell adhesion molecule
  3. a p < 0.05 versus healthy non-pregnant women
  4. b p < 0.001 versus healthy non-pregnant women
  5. c p < 0.05 preeclamptic patients versus healthy pregnant women
  6. d p < 0.001 preeclamptic patients versus healthy pregnant women