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Table 3 Serum levels (pg/ml) of cytokines, chemokines and adhesion molecules in healthy non-pregnant and pregnant women and preeclamptic patients

From: Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array

  Healthy non-pregnant women (n = 59) Healthy pregnant women (n = 60) Preeclamptic patients (n = 60)
IL-1β 24.5 (23.0-28.0) 27.0 (23.0-31.5) 28.0 (23.0-34.0)
IL-1ra 8.0 (6.7-11.0) 6.0 (5.0-7.0)b 18.0 (11.0-27.5)b,d
IL-2 5.0 (4.2-6.0) 4.0 (4.0-5.0)a 7.5 (5.5-12.0)b,d
IL-4 3.0 (2.0-3.0) 2.0 (2.0-2.0)b 3.0 (3.0-4.0)b,d
IL-6 6.0 (5.0-8.0) 7.0 (5.0-9.0) 15.5 (12.0-32.0)b,d
IL-8 23.0 (18.2-37.5) 24.5 (16.0-68.5) 78.0 (35.0-273)b,d
IL-10 43.7 (32.7-60.5) 15.7 (14.0-19.0)b 23.0 (18.0-35.0)b,d
IL-12p40 119 (109-140) 136 (118-168)a 185 (153-215)b,d
IL-12p70 12.0 (9.0-15.0) 5.0 (4.0-5.0)b 6.0 (5.0-8.0)b,d
IL-18 38.7 (33.0-46.5) 56.0 (44.0-73.7)b 73.5 (55.0-87.0)b,c
IFN-γ 4.0 (3.0-4.0) 3.0 (2.0-3.0)b 5.0 (4.0-6.0)b,d
TNF-α 2.0 (2.0-3.0) 2.0 (1.0-2.0)a 2.0 (2.0-3.0)d
TGF-β1 342 (285-388) 364 (307-413) 383 (331-418)
IP-10 198 (142-327) 327 (222-442)b 688 (434-928)b,d
MCP-1 153 (87.5-233) 79.5 (52.5-110)b 189 (120-283)d
ICAM-1 6638 (6143-7205) 6789 (6201-7672) 8132 (7413-8808)b,d
VCAM-1 6151 (5767-6564) 6157 (5633-6617) 7386 (6913-7709)b,d
  1. Data are presented as median (25-75 percentile)
  2. IL: interleukin; IL-1ra: IL-1 receptor antagonist; IFN: interferon; TNF: tumor necrosis factor; TGF: transforming growth factor; IP: interferon-γ-inducible protein; MCP: monocyte chemotactic protein; ICAM: intercellular adhesion molecule; VCAM: vascular cell adhesion molecule
  3. a p < 0.05 versus healthy non-pregnant women
  4. b p < 0.001 versus healthy non-pregnant women
  5. c p < 0.05 preeclamptic patients versus healthy pregnant women
  6. d p < 0.001 preeclamptic patients versus healthy pregnant women