Figure 2

Iloprost treatment reduces TNF α production from PBMCs after stimulus with PHA. TNF α was measured in the culture supernatants of PBMCs from SSc patients treated with iloprost at baseline and after treatment (5 days of daily treatment, 28 days after the last infusion), cultures were stimulated or not with PHA which predominantly stimulates T cells. A. Graph shows the level of TNF α supernatants 24 hrs after stimulus with PHA. Symbols represent mean and SD for all the patients, p values were calculated by paired Students' T test, significant values are displayed. B. Graph shows the level of TNF α supernatants without PHA. Symbols represent mean and SD, for all the patients.