Detection of autoantibodies against reactive oxygen species modified glutamic acid decarboxylase-65 in type 1 diabetes associated complications

Table 2 Clinical and laboratory data from complicated and uncomplicated T1D patients; normal human subjects serve as controls.

Subjects	Number of sera	Age (years ± SD)	Gender (M:F)	Smoking duration n(years ± SD)	Duration of disease (years ± SD)	Fasting blood glucose (mg/dl)	HbA_1C (%)	Hyperten-sion 140/90 (%)	Carbonyl Content (nmol/mg protein)
Uncomplic-ated T1D	60	30 ± 09	37:23	8(5 ± 3.4)	09 ± 5.6	238 ± 27^#	7.9 ± 0.7	36(60)	3.0 ± 0.22^#
Complicated T1D Nephropathy	20	37 ± 11	12:8	14(6 ± 3.8)	14 ± 4.9	311 ± 21*	8.8 ± 0.6*	17(85)	3.4 ± 0.28*
Complicated T1D Retinopathy	20	42 ± 14	11:9	17(8 ± 3.6)	17 ± 4.3	335 ± 17*	9.3 ± 0.7*	16(80)	3.9 ± 0.31*
Control	50	32 ± 8	28:22	--	--	96 ± 11.2	5.8 ± 0.4	4(8)	2.1 ± 0.17

Data are means ± SD or n represents number of smokers from given total respective subjects. For blood glucose estimations, blood was collected in oxalated fluoride containers and the assays were performed immediately. Hypertension is defined as sitting systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg or the use of antihypertensive medication. Signs * and ^# represents p values < 0.001 and < 0.05 respectively.

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