Figure 1
Detrimental role of NO in innate resistant C57BL/6 mice after B. pseudomallei challenge. (A) Survival curve of C57BL/6 wild type and iNOS-/- mice (n = 10) after intravenous (i.v.) infection with 0.2 - 1 × 105 CFU B. pseudomallei. Pooled data from two experiments are shown. (B) Bacterial burden in liver and spleen of C57BL/6 wild type and iNOS-/- mice 2 d and 13 d after i.v. infection with ~ 3 × 104 CFU B. pseudomallei. Pooled data from two independent experiments are shown. Each dot represents the bacterial count of the respective organ of a single animal. The line represents the median of each group. Statistical analyses were performed by using the Mann-Whitney test.