Figure 3

Differential function for NO in macrophages from C57BL/6 and BALB/c mice to control B. pseudomallei growth. (A) Intracellular survival of B. pseudomallei in IFN-γ stimulated BMM from C57BL/6 wild type and iNOS-/- mice (MOI ~ 50:1). One representative experiment out of five independent experiments is shown. (B) NO production of BALB/c macrophages without and with AG treatment after B. pseudomallei infection (MOI ~ 65). (C) Intracellular survival of B. pseudomallei in IFN-γ stimulated BALB/c BMM (MOI ~ 65) with and without AG treatment. One representative experiment out of three independent experiments is shown. Values are the means ± standard deviations from triplicate determinations. Statistical analysis was performed using the Student's t-test.