Table 4 COG functional analysis of Brucella genes associated with vaccine research
| Â | VO-associated Genes (n = 140) | Virulent Genes (n = 46) |
|---|---|---|
COG Description | # of genes (p-value) | # of genes (p-value) |
Amino acid transport and metabolism | 12 (0.771) | 4 (1.000) |
Carbohydrate transport and metabolism | 19 (0.000*) | 6 (0.043*) |
Cell cycle control, cell division, chromosome partitioning | 1 (1.000) | Â |
Cell motility | 1 (1.000) | 1 (0.341) |
Cell wall/membrane/envelope biogenesis | 22 (0.000*) | 9 (0.001*) |
Coenzyme transport and metabolism | 4 (0.820) | Â |
Energy production and conversion | 5 (0.843) | 1 (0.728) |
Inorganic ion transport and metabolism | 10 (0.149) | 3 (0.475) |
Intracellular trafficking, secretion, and vesicular transport | 7 (0.003*) | 5 (0.000*) |
Lipid transport and metabolism | 3 (0.627) | 1 (1.000) |
Nucleotide transport and metabolism | 2 (0.769) | 1 (1.000) |
Posttranslational modification, protein turnover, chaperones | 16 (0.000*) | 5 (0.025*) |
Replication, recombination and repair | 14 (0.001*) | 3 (0.428) |
Secondary metabolites biosynthesis, transport and catabolism | 3 (0.750) | 1 (0.601) |
Signal transduction mechanisms | 3 (1.000) | 2 (0.357) |
Transcription | 6 (0.704) | 2 (1.000) |
Translation, ribosomal structure and biogenesis | 5 (0.684) | Â |