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Table 4 COG functional analysis of Brucella genes associated with vaccine research

From: Ontology-based Brucella vaccine literature indexing and systematic analysis of gene-vaccine association network

  VO-associated Genes
(n = 140)
Virulent Genes
(n = 46)
COG Description # of genes (p-value) # of genes (p-value)
Amino acid transport and metabolism 12 (0.771) 4 (1.000)
Carbohydrate transport and metabolism 19 (0.000*) 6 (0.043*)
Cell cycle control, cell division, chromosome partitioning 1 (1.000)  
Cell motility 1 (1.000) 1 (0.341)
Cell wall/membrane/envelope biogenesis 22 (0.000*) 9 (0.001*)
Coenzyme transport and metabolism 4 (0.820)  
Energy production and conversion 5 (0.843) 1 (0.728)
Inorganic ion transport and metabolism 10 (0.149) 3 (0.475)
Intracellular trafficking, secretion, and vesicular transport 7 (0.003*) 5 (0.000*)
Lipid transport and metabolism 3 (0.627) 1 (1.000)
Nucleotide transport and metabolism 2 (0.769) 1 (1.000)
Posttranslational modification, protein turnover, chaperones 16 (0.000*) 5 (0.025*)
Replication, recombination and repair 14 (0.001*) 3 (0.428)
Secondary metabolites biosynthesis, transport and catabolism 3 (0.750) 1 (0.601)
Signal transduction mechanisms 3 (1.000) 2 (0.357)
Transcription 6 (0.704) 2 (1.000)
Translation, ribosomal structure and biogenesis 5 (0.684)  
  1. Note: * indicates p < 0.05.