Figure 4
From: Inhibitory effects of the JAK inhibitor CP690,550 on human CD4+ T lymphocyte cytokine production
Effects of CP690, 550 on granzyme B mRNA expression in activated CD8+ T cells. CD8+ T cells were stimulated with CD3 monoclonal antibodies in the presence or absence of CP690,550. After 8-hr or 24-hr stimulation, total RNA was extracted and granzyme B mRNA expression was measured by real-time PCR. The results show a representative result from two independent experiments.