Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis

BMC Immunology

Table 2 Densitometric analysis of LacZ gene expression in specific lung cells during the process of fibrosis induced by bleomycin

Epithelial cells	PMN			Mono	MPC
		Intra-vascular	Trans-migrated	Intra-alveolar	Intra-vascular	Tissue	Intra-alveolar
Sham	61 ± 3	53 ± 2	60 ± 2	65 ± 2	50 ± 3	55 ± 2	65 ± 3
Bleo 7d	108 ± 10 *	65 ± 3	103 ± 5 *	110 ± 6 *	63 ± 2	70 ± 3 *	73 ± 3
Bleo 21d	180 ± 20***	60 ± 3	105 ± 4*	108 ± 5*	61 ± 2	105 ± 5 **	111 ± 10 *

AnxA1 null mice were treated with bleomycin (0.15 U/Kg i.t.) at time 0 and lung collected at the reported time points. X-Gal staining was done as described in Material and Methods. Values (densitometric units) are mean ± SEM of 10 histological tissue sections analyzed from five mice per group. * P < 0.05 versus sham group values. ** P < 0.01 versus sham group values. *** P < 0.001 versus sham group values.

ISSN: 1471-2172