Figure 7
UPGMA phylogenetic tree depicting the evolutionary relationship of vertebrate HLP1 proteins. The tree was constructed using the neighbour-joining method based on the alignment of the complete cDNA coding sequences of known vertebrate Hb-LP s. The scale bar refers to evolutionary distances in substitutions per site. Bootstrap values (1000 replicates) indicating the occurrence of nodes are reported above each branch in the figure. GenBank accession numbers for HLP1 cDNA sequence comparisons are: XM844635.2 [Dog H2B (Canis lupus familiaris)]; XM002930226.1 [Giant panda (Ailuropoda melanoleuca)]; XM_001505029.2 [Horse (Equus caballus)]; XM_001367484.1 [Gray short-tailed opossum (Monodelphis domestica)]; XM_001515033.1 [Platypus (Ornithorhynchus anatinus); XM_003259153.1 [Northern white-cheeked gibbon (Nomascus leucogenys)]; NM_080593.2 [Human (Homo sapiens)]; XM_003311114.1 [Chimpanzee (Pan troglodytes); XM_003416418.1 [African savanna elephant (Loxodonta africana)]; AB124798.1 [Japanese gliding frog (Rhacophorus schlegelii)]; XM_003226650.1 [Green anole (Anolis carolinensis)]; XM_427116.1 [Red jungle fowl (Gallus gallus)]; XM_003201926.1 [Turkey (Meleagris gallopavo)]; JN410660 [Sea bass (Dicentrarchus labrax)]; GU982558.1 [orange-spotted grouper (Epinephelus coioides)]; X02916.1 [Rainbow trout (Onchorhynchus mykiss)]; AB435638.1 [Japanese medaka (Oryzias latipes)]; XM_002666939.1 [Zebrafish (Danio rerio)].