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Figure 5 | BMC Immunology

Figure 5

From: Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)

Figure 5

GMCSF-MOG TTV prevented histological signs of EAE. Shown are representative histological sections from mice from Figure 4, experiment 2. Mice from control groups that were afflicted with severe EAE had perivascular infiltrations of mononuclear cells typical of EAE in the cervical (a) and lumbar (b, c) regions of the spinal cord. In contrast, GMCSF-MOG treated mice did not show inflammatory lesions in the CNS, as portrayed by the cervical (d) and lumbar sections (e, f) of the spinal cord.

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BMC Immunology

ISSN: 1471-2172

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