Figure 5

Investigation of adenovirus induced immune reaction in vivo. (A) Quantitative GFP fluorescence and (B) numbers of leucocytes (WBC), granulocytes (GRA), lymphocytes (LYM) and monocytes (MO) in immunocompetent, hairless mice (SKH-1^h/r) at timepoints of 14, 28 and 42 days after intradermal injection of 10⁸ - 10¹⁰ IU Ad-GFP. (C) RT-PCR analysis of IFN-α and IFN-β expression 48 h after intradermal injection of 10¹⁰ IU Ad-GFP in immunocompetent (SKH) and athymic (Foxn) mice. Results were normalised to an untreated control area.