Figure 3

Computer-aided homology analysis of LaDR5. A: Homology modeling of LaDR5 Fv, designating V_H (pink) and V_L fragments (blue). Then CDR domains of heavy and light chains were marked with green (H_CDR1-2), yellow (L_CDR1-2), red (H_CDR3) and white (L_CDR3), respectively; B: theoretical structure of LaDR5 (red)-DR5 (pink) complex. The green-line area was the intact suface of the two; C: The intact suface between DR5-LaDR5, indicating the key residues of DR5 containing Ser³⁵, Glu³⁶, Phe⁵⁹, Arg⁶², Arg⁶⁵, Asp⁶⁷, Ser⁶⁸, Ser⁹⁶, Glu⁹⁸, Arg¹⁰¹, Lys¹⁰², Arg¹⁰⁴ and Thr¹⁰⁵.