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Table 2 The sequences of the chosen epitopes were compared to the consensus sequence and conservation scores (as percentages) were calculated

From: Sequence-based in silico analysis of well studied Hepatitis C Virus epitopes and their variants in other genotypes (particularly genotype 5a) against South African human leukocyte antigen backgrounds

CLASS I EPITOPE Consensus Epitope sequence HCV GENOTYPES Mean across genotypes MAX. MIN. SD p-value
   1 2 3 4 5 6      
NS31073-1081 CINGVMWTV 78 67 67 67 78 67 70.67 67 78 5.680 0.3062
NS31406-1415 LTSLGLNAV 67 56 67 78 67 56 65.17 56 78 8.280 0.1645
NS41807-1816 LLFNILGGW 100 78 78 100 100 78 89.00 78 100 12.049 0.6513
NS41851-1859 ILAGYGAGV 89 67 89 78 89 67 79.83 67 89 10.815 0.2231
NS5B2422-2433 MSYSWTGAL 89 89 89 100 89 67 87.17 67 100 10.815 0.406
NS5B2727-2735 GLRDCTMLV 78 56 44 78 78 33 61.17 33 78 19.823 0.4142
  Mean within genotypes 83.50 68.83 72.33 83.50 83.50 61.33      
CLASS II EPITOPE Consensus Epitope sequence 1 2 3 4 5 6 Mean across genotypes MAX. MIN. SD p-value
CORE17-40 RRPQDVKFPGGGQIVGGVYLLPRR 100 96 66 96 96 96 91.67 67 78 5.680 0.3062
NS31248-1261 GYKVLVLNPSVAAT 100 93 93 100 100 93 96.50 93 100 3.834 0.32
NS31781-1800 LPGNPAVASLMATAAVTSP 85 80 95 85 90 65 83.33 65 95 10.327 0.4142
NS41801-1820 LTTSQTLLFNILGGWVASQL 85 65 80 90 85 70 79.17 65 90 9.703 0.962
NS5B2571-2590 KGGRKPALIVYPDLGVRVC 80 80 90 95 95 80 86.67 80 95 7.527 0.2231
NS5B2661-2680 QCCDLEPEARVAIKSLTERL 85 55 70 80 60 50 66.67 50 85 14.023 0.4159
  Mean within genotypes 89.17 78.17 82.33 91.00 87.67 75.67