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Table 3 Binding affinity scores of published epitopes and their variants were determined by the IEDB prediction program to relevant supertypes in South Africa

From: Sequence-based in silico analysis of well studied Hepatitis C Virus epitopes and their variants in other genotypes (particularly genotype 5a) against South African human leukocyte antigen backgrounds

Gene Epitope sequence Genotype of epitope   Class A- Alleles Class B- Alleles
    Supertypes A01 A02 A24 A01A03 A01A24 B07 B58 B27
    Allele type A*01:01 A*02:01 A*68:02 A*23:01 A*30:01 A*29:02 B*07:02 B*35:01 B*53:01 B*57:01 B*58:01 B*15:03 B*27:05
NS3 (A*02) CINGVCWTV 1a   17802 67 61 14908 15501 12611 23637 20927 25523 19827 13679 19257 23485
1073-1081 CVNGVCWTV 1b   16997 110 20 12228 13122 11766 21885 15696 13382 18288 12132 20367 23007
  SISGVLWTV 2a variant   18961 11 16 21483 11417 11417 22455 22186 29702 18590 15055 15691 20667
  TVGGVMWTV 3a   19940 64 8 12677 14750 9776 20729 21877 24623 16182 18054 26500 24303
  AVNGVMWTV 4a variant   17734 23 14 24001 4015# 12036 10753 20258 20595 17093 12996 13641 18882
  CINGVLWTV 5a   15172 26 39 17548 13613 13865 23524 21854 15854 18628 11203 17516 21090
  CINGVMWTL 5a variant   17922 140 101 10449 14413 11435 18947 13165 11237 2239 13165 13572 19956
NS3 (A*02) KLVALGINA 1a   22719 273 15048 32261 1830 18800 24242 25216 37253 23529 20557 4839 19019
1406-1415 KLSGLGLNA 1b   19133 475 21824 33559 2557 13152 20740 27147 37083 23891 19220 8973 18099
  QLTSLGLNA 4a   20013 7051 15292 33674 12859 12517 26454 24440 37244 22168 26218 7165 19904
  KLVALGINAV 1a   37929 52 8564 39134 NO VALUE 31977 19547 42247 34339 NO VALUE NO VALUE NO VALUE 26021
  LTGLGINAV 5a   12100 5692 304 32426 10980 20519 21309 20981 33652 25012 21599 12577 26332
  QLTGLGINA 5a variant   22408 6972 7419 34672 13389 17488 26117 23541 36968 25569 22283 15466 20054
NS4B (A*02) LLFNILGGW 1a, 1b, 4, 5a   22942 14359 17095 18086 17906 9175 24903 19854 17154 956# 962# 5918 23118
1807-1816 MFFNILGGWV 3a   24613 23482 19706 343 15640 1707# 21757 11817 8151 10769 1251 13832 26621
  LLFNILGGWV 1a, 1b, 4, 5a   32231 44 1159# 38969 NO VALUE 19453 32445 40287 25767 NO VALUE NO VALUE NO VALUE 25868
NS4B (A*02) ILAGYGAGV 1a, 1b, 5a   20500 15 530# 30882 15492 10120 11883 21134 37213 22934 20702 3735 20143
1851-1859 ILAGYGTGV 5a variant   20351 18 193 32028 17493 12563 11272 21994 36657 23555 20603 2196 19849
NS5B (B*15) MSYSWTGAL 1a, 1b, 4   12612 1522 24 2924 2372 5457 1530# 50 8456 10166 523# 80 16876
2422-2433 MSYTWTGAL 5a   12133 2640 22 8602 2141# 7606 2515# 58 9150 10680 787# 144 17267
  YTWTGALIT 5a variant   15779 3000 13286 33166 13737 1561 18979 3920 27619 22480 17360 6553 18765
NS5B (A*02) GLQDCTMLV 1a   18371 8 5733 11972 13187 6275 20996 27015 35681 25282 22002 10687 17601
2727-2735 KLQDCTMLV 1b   17735 7 3878 6160 2071# 9527 17308 26776 35038 23310 18296 3587 16634
  KLRDCTLLV 5a   19744 13 14912 15150 10 5150 2800 27145 36627 21481 20362 1720# 18071
  ALRDCTMLV 4a   19976 19 4673 19836 29 9982 5384 26302 36740 24190 22343 1206# 20027
  1. <50 IC50nm, bold, high affinity.
  2. >50 IC50nm, <500 IC50nm, italic, intermediate affinity.
  3. >500 IC50nm, #, poor affinity.
  4. No value indicates server produced no binding score.