Table 2 Humoral and cellular immune responses
| Â | Chronic fatigue syndrome patients (n=20) | Healthy controls (n=20) | p-value |
|---|---|---|---|
Seroprotection rate pre-vaccination (day 1) | |||
 H3N2 | 13 (65) | 12 (60) | 0.744 |
 H1N1 | 4 (20) | 5 (25) | 0.705 |
 B | 16 (80) | 17 (85) | 0.677 |
 H3N2, H1N1, and B | 2 (10) | 4 (20) | 0.376 |
Seroprotection rate post-vaccination (day 22) | |||
 H3N2 | 18 (90) | 20 (100) | 0.147 |
 H1N1 | 18 (90) | 18 (90) | 1.000 |
 B | 18 (90) | 20 (100) | 0.147 |
 H3N2, H1N1, and B | 15 (75) | 18 (90) | 0.212 |
Seroresponse rate post-vaccination (day 1 to 22) | |||
 H3N2 | 10 (50) | 12 (60) | 0.525 |
 H1N1 | 13 (65) | 12 (60) | 0.744 |
 B | 2 (10) | 3 (15) | 0.633 |
 H3N2, H1N1, and B | 1 (5) | 2 (10) | 0.548 |
IL-10 production at baseline (day 1, pg/ml) | |||
 H3N2 | 4.5±10.9 | 2.5±5.0 | 0.457 |
 H1N1 | 65.6±127.4 | 35.3±47.2 | 0.329 |
 B | 19.3±56.0 | 10.5±20.2 | 0.514 |
Treg at baseline (day 1, %) | |||
 Unstimulated | 2.8±1.2 | 2.7±1.5 | 0.733 |
IFN-γ production post-vaccination (day 8, pg/ml) | |||
 H3N2 | 162.1±220.5 | 116.0±180.8 | 0.474 |
 H1N1 | 578.3±828.8 | 382.5±446.1 | 0.360 |
 B | 316.4±520.7 | 418.1±528.9 | 0.544 |
IL-4 production post-vaccination (day 8, pg/ml) | |||
 H3N2 | 0.0±0.0 | 4.3±13.5 | 0.169 |
 H1N1 | 0.0±0.0 | 7.7±20.2 | 0.105 |
 B | 2.9±8.8 | 0.0±0.0 | 0.163 |
IL-5 production post-vaccination (day 8, pg/ml) | |||
 H3N2 | 1.4±4.3 | 1.7±4.7 | 0.811 |
 H1N1 | 1.2±3.4 | 1.5±4.5 | 0.788 |
 B | 0.8±3.4 | 3.4±6.4 | 0.114 |