Figure 6

Impact of prophylactic sIgA on DSS-induced myeloid-derived suppressor cells at day 15. The indicated therapeutics (sIgA, IgG, and BC) were applied parallel to DSS treatment. The untreated group represents healthy animals without any intervention. Values are provided as percent total CD11b⁺Gr-1⁺ cells positive cells (A) or subpopulations with low, intermediate (int) or high CD11b⁺Gr-1⁺ co-expression in 10,000 measured events (B). Values are given as mean ± SD. n = 6-8 (Untreated), n = 6 (BC, sIgA), and n = 5 (IgG) mice. *P < 0.05 vs. untreated, ⁺P < 0.05 vs. sIgA, n.s. = not significant IgG vs. sIgA, Mann Whitney U-test.