Figure 5
From: Inhibitory effect of IL-17 on neural stem cell proliferation and neural cell differentiation
IL-17 increases p38 MAPK level in NSCs. NSCs were cultured at 400 cells/ml in 6-well plates and treated with IL-17 for 48 h, as described in Materials and Methods. SB203580 was added to culture medium 2 h before IL-17 was added. (a) Newly formed NSCs treated with IL-17 (25 ng/ml), with or without addition of SB203580 (15 μM). (b) Number of NSCs treated with IL-17 (25 ng/ml), with or without addition of SB203580 (15 μM). (c) Western blot for p38 MAPK level in NSCs. Mean percentages were determined from three independent experiments. NS, not significant.