BMC Immunology

Table 2 Linear classification models separating healthy male subjects from male subjects with GWI or CFS

From: A comparison of sex-specific immune signatures in Gulf War illness and chronic fatigue syndrome

	Model	Stand. coeff.	Assigned HC	Assigned GWI or CFS	Total		Accuracy	NPV	PPV	Specificity	Sensitivity
Male GWI Subjects
GWI vs HC males at T0	Il-10 T0	−1.32	16	5	21	True HC male	0.73	0.73	0.74	0.76	0.70
	Il-13 T0	1.23	6	14	20	True GWI male
	Il-23 T0	0.53
GWI vs HC males at T1	NA					True HC male	NA	NA	NA	NA	NA
						True GWI male
GWI vs HC males at T2	Il-1b T2	−0.59	14	7	21	True HC male	0.73	0.78	0.70	0.67	0.80
	Il-10 T2	−1.10	4	16	20	True GWI male
	Il-13 T2	1.02
	Il-23 T2	0.62
GWI vs HC males at T0-T2	Il-15 T2	−0.64	17	4	21	True HC male	0.83	0.85	0.81	0.81	0.85
	Il-10 T0	−1.34	3	17	20	True GWI male
	Il-13 T0	1.16
	Il-23 T0	0.57
	IFNg T1	0.55
Male CFS Subjects
CFS vs HC males at T0	Il-23 T0	1.00	16	5	21	True HC male	0.76	0.84	0.64	0.76	0.75
			3	9	12	True CFS male
CFS vs HC males at T1	Il-2 T1	1.84	16	5	21	True HC male	0.82	0.94	0.69	0.76	0.92
	Il-6 T1	−0.66	1	11	12	True CFS male
	Il-10 T1	−0.75
	Il-15 T1	−0.66
CFS vs HC males at T2	Il-23 T2	1.00	16	5	21	True HC male	0.73	0.80	0.62	0.76	0.67
			4	8	12	True CFS male
CFS vs HC males at T0-T2	Il-2 T2	0.99	18	3	21	True HC male	0.85	0.90	0.77	0.86	0.83
	Il-10 T2	1.37	2	10	12	True CFS male
	Il-23 T2	0.85
	Il-10 T1	−2.18
	Il-12p70 T1	−0.93

Performance values correspond to leave-one-out cross validation results.

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