Figure 5

Tumor and tumor-draining lymph node cell counts and mean-fluorescence intensities on day 4 post tumor-inoculation

Tumor and tumor-draining lymph node cell counts and mean-fluorescence intensities on day 4 post tumor-inoculation. The total number of lymphocytes and DCs in TDLNs (A) of tumor-bearing mice were significantly increased compared to naïve non tumor-bearing mice. Furthermore, the expression of CD86 on CD11c⁺ cells was significantly lower in naïve non tumor-bearing mice compared to tumor-bearing mice. However, no significant differences in the total number of DCs, CD8⁺ T cells, or CD4⁺ T cells in TDLNs, or the percentages of CD45⁺, CD4⁺, CD8⁺, or CD11c⁺ in tumors (B) were found between tumor-bearing mice pretreated with IgG2a and tumor-bearing mice pretreated with sTGF-βR (* denotes p < 0.05).