Neonatal infections in Saudi Arabia: association with C-reactive protein, CRP -286 (C>T>A) gene polymorphism and IgG antibodies

Table 2 Description of CRP -286 (C>T>A) genotype polymorphism in the study groups

CRP genotypes^*	Sepsis- free controls n = 68 (%)	Suspected n = 68 (%)	Early onset sepsis n = 69 (%)	Hardy-Weinberg equilibrium test
TT	10 (14.7%)	2 (2.9%)	13 (18.8%)	0.201
AA	3 (4.4%)	15 (22.1%)	1 (1.4%)
AC	19 (27.9%)	30 (44.1%)	10 (14.5%)
AT	13 (19.1%)	7 (10.3%)	8 (11.6%)
CC	18 (26.5%)	8 (11.8%)	21 (30.4%)
CT	5 (7.4%)	6 (8.8%)	16 (23.2%)
*Alleles frequency* ^‡
C	0.44	0.38	0.50
T	0.28	0.13	0.36
A	0.27	0.49	0.14
*Allele carriers* ^§
Non- A- Allele	33 (48.5%)	16 (23.5%)	49 (71.0%)
A- Allele	35 (51.5%)	52 (76.5%)	20 (29.0%)

^* Overall genotypic frequency; Odds Ratio [OR] = 1.34; 95% Confidence Interval [CI] = (1.07- 1.67), P value = 0.010.
^‡ Overall allelic frequency; OR = 3.28; 95% CI = (1.92-5.59), P value < 0.001.
^§ Overall allelic carriers; OR = 5.11; 95% CI = (1.74- 8.01), P value = 0.003.

ISSN: 1471-2172