Figure 6

HIV-1 infected cells have decreased capacity to induce IFN-γ secretion by CD1c-restricted T cells. (A) Jurkat cells were either mock or HIV-1 IIIb infected with or without 10 μM simvastatin for 10 days. The cells were then used to stimulate CD1c-restricted T cells for 24 hours. Supernatants were collected and subjected to IFN-γ ELISA. (B) HIV-infected cells were cultured with or without CD1c-restricted T cells overnight, and p24 was subsequently measured in supernatants. These data represent results from one of three independent experiments.