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Table 1 T cells stimulated with proTα- or proTα(100–109)-matured DCs proliferate in the presence of HER-2(15 776 )-pulsed DCs

From: Prothymosin α and a prothymosin α-derived peptide enhance TH1-type immune responses against defined HER-2/neu epitopes

DCs matured with

DCs pulsed with

Mean counts per minute (cpm) ± SD*

Stimulation index (S.I.) ± SD*

TNF-α

-

13693 ± 1413

1

HER-2(15776)

42314 ± 7139

3.09 ± 0.52

tyr(15448)

16433 ± 1840

1.20 ± 0.13

HER-2(15776) + anti-MHC class II

11914 ± 2033

0.87 ± 0.15

ProTα

-

13145 ± 1742

1

HER-2(15776)

34702 ± 5143

2.64 ± 0.39

tyr(15448)

17220 ± 2974

1.31 ± 0.23

HER-2(15776) + anti-MHC class II

12225 ± 2603

0.93 ± 0.20

ProTα(100–109)

-

14577 ± 1041

1

HER-2(15776)

32944 ± 6567

2.26 ± 0.45

tyr(15448)

15306 ± 3608

1.05 ± 0.25

HER-2(15776) + anti-MHC class II

14285 ± 2989

0.98 ± 0.20

  1. * Mean cpm, S.I. ± SD from 2–5 donors.