Table 1 Biomarker levels in individual serum without pooling from collagen disease patients in the stable and AoDILD states
Biomarker (pg/ml) | Stable | AoDILD | P | ||
|---|---|---|---|---|---|
TIMP-1 | 207843 | (57972) | 285600 | (98476) | 0.015 |
TIMP-2 | 121481 | (22995) | 101922 | (18568) | 0.006 |
TIMP-3 | 15662 | (11925) | 15653 | (7974) | 0.196 |
TIMP-4 | 2908 | (941) | 2874 | (837) | 0.906 |
MMP-3 | 854165 | (668239) | 499442 | (312919) | 0.010 |
MMP-9 | 2615399 | (1577133) | 2837226 | (1619793) | 0.563 |
TGF-β1 | 57391 | (12908) | 52821 | (16415) | 0.101 |
TGF-β2 | 2475 | (889) | 2201 | (997) | 0.101 |
TGF-β3 | 0 | (0) | 0 | (0) | 1.000 |
Leptin | 6424 | (6663) | 6275 | (8249) | 0.670 |
Osteopontin | 14603 | (12657) | 30216 | (33636) | 0.012 |
Insulin | 633 | (475) | 589 | (330) | 0.961 |
EGF | 131 | (124) | 130 | (189) | 0.355 |
Eotaxin2 | 4497 | (3166) | 4223 | (5065) | 0.018 |
Eotaxin3 | 44 | (71) | 37 | (52) | 0.625 |
IL-17 F | 125 | (340) | 168 | (519) | 0.761 |
IL-1α | 61 | (248) | 137 | (607) | 1.000 |
IL-1RA | 156 | (330) | 401 | (490) | 0.049 |
IL-2 | 41 | (121) | 77 | (246) | 0.427 |
IL-2Rα | 3623 | (2134) | 7469 | (6483) | 0.001 |
IL-6 | 103 | (234) | 363 | (794) | 0.035 |
Fas | 2237 | (9967) | 3450 | (13337) | 0.715 |
FasL | 68 | (63) | 74 | (74) | 0.763 |
TNFα | 841 | (1953) | 1052 | (2676) | 0.821 |
MMP-1 | 69662 | (86194) | 75510 | (58379) | 0.016 |
MMP-12 | 4992 | (14919) | 7406 | (23641) | 0.500 |
MMP-7 | 5874 | (5153) | 7871 | (11084) | 0.627 |
MMP-13 | 37860 | (74534) | 52019 | (111830) | 0.754 |
MMP-8 | 25817 | (17712) | 48700 | (54791) | 0.144 |
LIF | 57 | (150) | 121 | (353) | 0.441 |
MIF | 17352 | (34236) | 23178 | (29813) | 0.136 |
MMP-3/MMP-1 | 22.04 | (18.56) | 15.00 | (19.61) | 0.0208 |