Table 3 Laboratory findings and serum biomarker levels of collagen disease patients with AE-ILD or DI-ILD in stable and AoDILD states

White Blood Cell count (X1000/ml)

10.9 (2.7)

11.8 (2.6)

0.2135

10.3 (4.0)

12.1 (3.8)

0.2604

Red Blood Cell count (X10⁶/ml)

4.2 (0.9)

4.4 (0.7)

0.9528

4.2 (0.5)

4.1 (0.6)

0.5536

Hemoglobin (g/dl)

13.4 (1.2)

12.7 (2.5)

0.2936

12.6 (2.3)

12.2 (1.9)

0.5147

Hematocrit (%)

42.1 (3.1)

38.9 (6.4)

0.0152

38.9 (6.4)

36.9 (5.9)

0.9528

Platelet (X1000/ml)

280.3 (58.0)

299.5 (110.0)

0.3139

318.2 (139.3)

293.5 (118.8)

0.8590

Albumin (g/dl)

4.1 (0.3)

3.6 (0.7)

0.0077

3.9 (0.4)

3.2 (0.6)

0.0687

Aspartate Aminotransferase (IU/l)

41.2 (47.9)

44.4 (32.4)

0.6784

23.2 (4.6)

31.8 (13.6)

0.1282

Alanine Aminotransferase (IU/l)

36.6 (43.2)

39.0 (36.2)

0.4838

19.7 (6.8)

18.0 (6.0)

0.6784

Lactate Dehydrogenase (IU/l)

250.7 (45.3)

311.6 (86.2)

0.1386

215.2 (23.8)

383.6 (158.3)

0.0209

Alkaline Phosphatase (IU/l)

278.1 (141.2)

239.3 (97.9)

0.7794

243.8 (89.5)

261.8 (90.2)

0.9528

γ-glutamyltransferase (IU/l)

52.2 (44.4)

179.5 (392.2)

0.1551

26.3 (18.0)

31.1 (14.9)

0.4990

Creatinine (mg/dl)

0.7 (0.1)

0.7 (0.1)

0.8127

0.6 (0.1)

0.7 (0.2)

0.8127

Blood Urea Nitrogen (mg/dl)

13.9 (2.3)

17.1 (6.2)

0.1097

14.4 (3.1)

16.8 (3.5)

0.4008

C-reactive protein (mg/dl)

2.1 (2.3)

6.4 (10.1)

0.1097

3.9 (4.1)

11.2 (7.7)

0.2135

KL-6 (U/ml)

2078.1 (2525.4)

2105.8 (2495.5)

0.0280

431.0 (256.6)

799.7 (425.9)

0.0208

Surfactant Protein-D (ng/ml)

160.7 (126.5)

194.7 (123.2)

0.1763

76.4 (53.5)

170.5 (163.6)

0.0619

TIMP-1 (pg/ml)

192899 (54474)

245030 (93165)

0.3105

218303 (58054)

313999 (91931)

0.0166

TIMP-2 (pg/ml)

123534 (24219)

100422 (12693)

0.1763

120044 (21985)

102973 (21694)

0.0125

TIMP-3 (pg/ml)

16813 (5411)

18791 (9923)

0.7353

14857 (14822)

13457 (5240)

0.1097

MMP-3 (pg/ml)

587882 (245290)

628244 (328962)

0.5940

1025348 (787427)

416640 (271619)

0.0019

MMP-9 (pg/ml)

2852316 (1698909)

2800269 (1205613)

0.5940

2463095 (1473636)

2860985 (1837002)

0.5509

Osteopontin (pg/ml)

12464 (10678)

28442 (35397)

0.0663

15979 (13604)

31356 (32402)

0.0736

Eotaxin2 (pg/ml)

3953 (2312)

5311 (5724)

0.3139

4846 (3566)

3523 (4453)

0.0258

IL-1RA (pg/ml)

94 (111)

417 (653)

0.0796

196 (409)

390 (346)

0.2209

IL-2Rα (pg/ml)

2611 (1669)

3689 (2047)

0.0506

4274 (2147)

9899 (7159)

0.0076

IL-6 (pg/ml)

37 (47)

238 (422)

0.0209

145 (290)

444 (952)

0.2455

MMP-1 (pg/ml)

26532 (18626)

44551 (43273)

0.1097

97389 (100090)

95411 (58164)

0.0962

MMP-8 (pg/ml)

24640 (18134)

49581 (74715)

0.3743

26573 (17394)

48134 (36641)

0.1401

MMP-3/MMP-1

29.78 (16.71)

29.11 (24.88)

0.7671

17.07 (17.98)

5.92 (4.81)

0.0043